N-(3-(3-(9H-purin-6-yl)pyridin-2-ylamino)-2,4-difluorophenyl)-1-chloromethanesulfonamide | 1437316-60-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: N-(3-(3-(9H-purin-6-yl)pyridin-2-ylamino)-2,4-difluorophenyl)-1-chloromethanesulfonamide
• 英文别名: 1-chloro-N-[2,4-difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]methanesulfonamide
• CAS: 1437316-60-3
• 化学式: C₁₇H₁₂ClF₂N₇O₂S
• 分子量: 451.844
• InChiKey: LJDVFTJHWFFLBG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  134
• 氢给体数：
  3
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  6-(2-fluoropyridin-3-yl)-9-(tetrahydro-2H-pyran-2-yl)-9H-purine 、 N-(3-amino-2,4-difluorophenyl)-1-chloromethanesulfonamide 生成 N-(3-(3-(9H-purin-6-yl)pyridin-2-ylamino)-2,4-difluorophenyl)-1-chloromethanesulfonamide
  参考文献：
  名称：

  KINASE MODULATING COMPOUNDS, COMPOSITIONS CONTAINING THE SAME AND USE THEREOF

  摘要：

  本发明提供了一种由公式（I）所表示的化合物，该化合物可以调节激酶，以及其制备的药物组合物和预防或治疗蛋白激酶介导的疾病或病状的方法。

  公开号：

  US20140296261A1

文献信息

• [EN] KINASE MODULATING COMPOUNDS, COMPOSITIONS CONTAINING THE SAME AND USE THEREOF<br/>[FR] COMPOSÉS MODULANT UNE KINASE, COMPOSITIONS LES CONTENANT ET UTILISATION DE CEUX-CI
  申请人：CENTAURUS BIOPHARMA CO LTD

  公开号：WO2013071865A1

  公开（公告）日：2013-05-23

  The invention provides a compound represented by formula (I) which may modulate a kinase, and a pharmaceutical composition thereof, as well as the method for preventing or treating a protein kinase mediated disease or condition.

  该发明提供了一种由式(I)表示的化合物，可以调节激酶，以及其药物组合物，以及预防或治疗蛋白激酶介导的疾病或病况的方法。
• Method for Producing Bio-Based Homoserine Lactone and Bio-Based Organic Acid from O-Acyl Homoserine Produced by Microorganisms
  申请人：CJ Cheiljedang Corporation

  公开号：US20140296466A1

  公开（公告）日：2014-10-02

  The present invention relates to a method of producing bio-based homoserine lactone and bio-based organic acid through hydrolysis of O-acyl homoserine produced by a microorganism in the presence of an acid catalyst. According to the present invention, O-acyl homoserine produced by a microorganism is used as a raw material for producing 1,4-butanediol, gamma-butyrolactone, tetrahydrofuran and the like, which are industrially highly useful. The O-acyl homoserine produced by a microorganism can substitute conventional petrochemical products, can solve environmental concerns, including the emission of pollutants and the exhaustion of natural resources, and can be continuously renewable so as not to exhaust natural resources.

  本发明涉及一种通过在酸催化剂存在下水解微生物产生的O-酰基同型半胱氨酸，生产基于生物的同型半胱氨酸内酯和基于生物的有机酸的方法。根据本发明，利用微生物产生的O-酰基同型半胱氨酸作为原料，生产1,4-丁二醇、γ-丁内酯、四氢呋喃等工业上非常有用的产品。微生物产生的O-酰基同型半胱氨酸可以替代传统的石化产品，可以解决环境问题，包括污染物排放和自然资源枯竭，并且可以持续可再生，不会耗尽自然资源。
• METHOD FOR PREPARING BIOBASED HOMOSERINE LACTONE HYDROCHLORIDE AND BIOBASED ORGANIC ACID FROM MICROORGANISM-DERIVED O-ACYL HOMOSERINE
  申请人：Cj Cheiljedang Corporation

  公开号：EP3150710A1

  公开（公告）日：2017-04-05

  The present invention relates to a method of producing bio-based homoserine lactone and bio-based organic acid through hydrolysis of O-acyl homoserine produced by a microorganism in the presence of an acid catalyst. According to the present invention, O-acyl homoserine produced by a microorganism is used as a raw material for producing 1,4-butanediol, gamma-butyrolactone, tetrahydrofuran and the like, which are industrially highly useful. The O-acyl homoserine produced by a microorganism can substitute conventional petrochemical products, can solve environmental concerns, including the emission of pollutants and the exhaustion of natural resources, and can be continuously renewable so as not to exhaust natural resources.

  本发明涉及一种在酸催化剂存在下，通过水解微生物产生的 O-酰基高丝氨酸来生产生物基高丝内酯和生物基有机酸的方法。根据本发明，由微生物生产的 O-酰基高丝氨酸可用作生产 1,4-丁二醇、γ-丁内酯、四氢呋喃等工业上非常有用的产品的原料。微生物生产的 O-酰基高丝氨酸可以替代传统的石油化工产品，可以解决污染物排放和自然资源耗竭等环境问题，并且可以持续再生，不会耗竭自然资源。
• Particulate polyamide, and method for preparing the particulate polyamide
  申请人：Arai Yoko

  公开号：US10138344B2

  公开（公告）日：2018-11-27

  A particulate polyamide is provided. The particulate polyamide is porous and includes at least one of polyamide 4 and polyamide 3. In addition, the particulate polyamide has a particle diameter (d50) of from 10 μm to 1,000 μm and a particle diameter dispersion degree (Dv/Dn) of not greater than 3.0, wherein Dv represents the volume average particle diameter of the particulate polyamide, and Dn represents the number average particle diameter of the particulate polyamide.

  提供了一种微粒聚酰胺。微粒聚酰胺是多孔的，至少包括聚酰胺 4 和聚酰胺 3 中的一种。此外，微粒聚酰胺的颗粒直径（d50）为 10 μm 至 1,000 μm，颗粒直径分散度（Dv/Dn）不大于 3.0，其中 Dv 代表微粒聚酰胺的体积平均颗粒直径，Dn 代表微粒聚酰胺的数量平均颗粒直径。
• METHOD FOR PREPARING HOMOSERINE LACTONE AND ORGANIC ACID FROM MICROORGANISM-DERIVED O-ACYL HOMOSERINE
  申请人：CJ Cheiljedang Corporation

  公开号：EP3150710B1

  公开（公告）日：2022-05-11