5-Formyl-2-methoxyphenyl prop-2-enoate | 651029-02-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: 5-Formyl-2-methoxyphenyl prop-2-enoate
• 英文别名: (5-formyl-2-methoxyphenyl) prop-2-enoate
• CAS: 651029-02-6
• 化学式: C₁₁H₁₀O₄
• 分子量: 206.19
• InChiKey: CNKKOACQGWWYHR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-碘萘 、 diphenyliodomethylphosphine oxide 、 5-Formyl-2-methoxyphenyl prop-2-enoate 在 potassium phosphate 、 三(4-甲氧苯基)膦 、 palladium diacetate 、 (1S,7R)-4-(4-methoxyphenyl)-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione 作用下， 以 乙腈 为溶剂， 以79 %的产率得到5-formyl-2-methoxyphenyl (E)-3-(2-((diphenylphosphoryl)methyl)naphthalen-1-yl)acrylate
  参考文献：
  名称：

  10.1021/acs.orglett.4c01944

  摘要：

  DOI：

  10.1021/acs.orglett.4c01944

文献信息

• Localized delivery system for cancer drugs, phenstatin, using N-isopropylacrylamide
  申请人：——

  公开号：US20040052761A1

  公开（公告）日：2004-03-18

  An injectable drug delivery system for localized release of Phenstatin to a tumor site over a period of time is provided. The drug delivery system comprises the thermoresponsive polymer N-isopropylacrylamide (NIPAAM) and Phenstatin, a toxic antineoplastic agent. The drug delivery system has a critical solution temperature (LCST) that causes it to change from the liquid state at room temperature when injected to a gel or semi-solid state after reaching the temperature of the human body in situ. Methods are given for delivering Phenstatin to a cancerous tumor. In these methods, the drug delivery system is injected into a tissue or into a tumor where it forms a gel. Phenstatin is slowly released from the polymer and exerts its cytotoxic, tublin-related effects on the tumor. Tumors that may be treated by the present methods include, but are not limited to breast, prostate, lung and bowel cancerous tumors.

  本研究提供了一种可注射的给药系统，用于在一段时间内向肿瘤部位局部释放苯司他丁。该给药系统由热致伸缩性聚合物 N-isopropylacrylamide (NIPAAM) 和 PhenSTatin（一种有毒的抗肿瘤药物）组成。该给药系统有一个临界溶液温度（LCST），使其在注射时从室温下的液态变为凝胶或半固态，当达到人体原位温度时则变为凝胶或半固态。 本文给出了将苯司他丁递送至癌症肿瘤的方法。在这些方法中，将给药系统注入组织或肿瘤中，使其形成凝胶。苯司他丁缓慢地从聚合物中释放出来，并对肿瘤产生细胞毒性和与微管蛋白相关的作用。本方法可治疗的肿瘤包括但不限于乳腺癌、前列腺癌、肺癌和肠癌。
• [EN] LOCALIZED DELIVERY SYSTEM FOR PHENSTATIN USING N-ISOPROPYLACRYLAMIDE<br/>[FR] SYSTEME D'ADMINISTRATION LOCALISEE DE PHENSTATINE AU MOYEN DE N-ISOPROPYLACRYLAMIDE
  申请人：UNIV ARIZONA

  公开号：WO2004009127A1

  公开（公告）日：2004-01-29

  An injectable drug delivery system for localized release of Phenstatin to a tumor site over a period of time is provided. The drug delivery system comprises the thermoresponsive polymer N-isopropylacrylamide (NIPAAm) and Phenstatin, a toxic antineoplastic agent. The drug delivery system has a critical solution temperature (LCST) that causes it to change from the liquid state at room temperature when injected to a gel or semi-solid state after reaching the temperature of the human body in situ. Methods are given for delivering Phenstatin to a cancerous tumor. In these methods, the drug delivery system is injected into a tissue or into a tumor where it forms a gel. Phenstatin is slowly released from the polymer and exerts its cytotoxic, tublin-related effects on the tumor. Tumors that may be treated by the present methods include, but are not limited to breast, prostate, lung and bowel cancerous tumors.