1-benzyl-1-ethyl-2-methylhydrazine | 1044792-49-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-benzyl-1-ethyl-2-methylhydrazine
• CAS: 1044792-49-5
• 化学式: C₁₀H₁₆N₂
• 分子量: 164.25
• InChiKey: TXYIKJKEJMIHTF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  15.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-benzyl-1-ethyl-2-methylhydrazine 、 乙酸酐 在 吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以67%的产率得到N'-benzyl-N'-ethyl-N-methylacetohydrazide
  参考文献：
  名称：

  Effective strategy for the systematic synthesis of hydrazine derivatives

  摘要：

  A new and efficient strategy for the systematic synthesis of hydrazine derivatives is reported. It allows the synthesis of up to tetrasubstituted hydrazine derivatives with minimal number of steps using only one protecting group or without any of them at all. Simple and readily available starting materials such as hydrazine hydrate or phenylhydrazine can be used. A variety of substrates were used to investigate scope and limitations of this strategy, additionally one full synthetic sequence was performed. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.04.096
• 作为产物：
  描述：

  tert-butyl 2-benzyl-2-ethyl-1-methylhydrazinecarboxylate 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以93%的产率得到1-benzyl-1-ethyl-2-methylhydrazine
  参考文献：
  名称：

  Effective strategy for the systematic synthesis of hydrazine derivatives

  摘要：

  A new and efficient strategy for the systematic synthesis of hydrazine derivatives is reported. It allows the synthesis of up to tetrasubstituted hydrazine derivatives with minimal number of steps using only one protecting group or without any of them at all. Simple and readily available starting materials such as hydrazine hydrate or phenylhydrazine can be used. A variety of substrates were used to investigate scope and limitations of this strategy, additionally one full synthetic sequence was performed. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.04.096

文献信息

• Carbidopa and L-dopa prodrugs and methods of use
  申请人：AbbVie Inc.

  公开号：US10174061B2

  公开（公告）日：2019-01-08

  The present disclosure relates to (a) carbidopa prodrugs, (b) pharmaceutical combinations and compositions comprising a carbidopa prodrug and/or an L-dopa prodrug, and (c) methods of treating Parkinson's disease and associated conditions comprising administering a carbidopa prodrug and an L-dopa prodrug to a subject with Parkinson's disease.

  本公开涉及(a)卡比多巴原药，(b)包含卡比多巴原药和/或左旋多巴原药的药物组合物和组合物，以及(c)治疗帕金森病及相关疾病的方法，包括向帕金森病患者施用卡比多巴原药和左旋多巴原药。
• US4393007A
  申请人：——

  公开号：US4393007A

  公开（公告）日：1983-07-12
• US4655970A
  申请人：——

  公开号：US4655970A

  公开（公告）日：1987-04-07
• [EN] MULTI-COMPONENT HOST MATERIAL AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING THE SAME<br/>[FR] MATÉRIAU HÔTE À CONSTITUANTS MULTIPLES ET DISPOSITIF ÉLECTROLUMINESCENT ORGANIQUE LE COMPRENANT
  申请人：ROHM & HAAS ELECT MAT

  公开号：WO2015174738A1

  公开（公告）日：2015-11-19

  The present invention relates to an organic electroluminescent device comprising at least one light-emitting layer between an anode and a cathode, wherein the light-emitting layer comprises a host and a dopant; the host consists of multi-component host compounds; at least a first host compound of the multi-component host compounds is a specific bicarbazole derivative containing an aryl group, and a second host compound is a specific carbazole derivative including a nitrogen-containing heteroaryl group. According to the present invention, an organic electroluminescent device using the multi-component host compounds has a high efficiency and long lifespan compared to the conventional organic electroluminescent device using one component of a host.