1-(3-chlorobenzyl)-5-(trifluoromethyl)pyridin-2(1H)-one | 1256782-98-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1-(3-chlorobenzyl)-5-(trifluoromethyl)pyridin-2(1H)-one
• 英文别名: 1-[(3-chlorophenyl)methyl]-5-(trifluoromethyl)pyridin-2-one
• CAS: 1256782-98-5
• 化学式: C₁₃H₉ClF₃NO
• 分子量: 287.669
• InChiKey: NRKFVVKIXYOQBP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-(3-chlorobenzyl)-5-(trifluoromethyl)pyridin-2(1H)-one 、 2-羟基-5-三氟甲基吡啶 、 disodium;carbonate 、 2-氟溴苄 、 氨 在 乙酸乙酯 、 Sodium sulfate-III 、 petroleum ether 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 以to obtain 0.65 of the product 1-(2-fluorobenzyl)-5-(trifluoromethyl)pyridin-2(1H)-one as a colorless oil的产率得到1-(2-fluorobenzyl)-5-(trifluoromethyl)pyridin-2(1H)-one
  参考文献：
  名称：

  Preparation of 1-(substituted benzyl)-5-trifluoromethyl-2(1H)pyridone compounds and salts thereof and their applications

  摘要：

  本发明公开了1-(取代苯基)-5-三氟甲基-2(1H)吡啶酮类化合物及其药学上可接受的盐。本发明还公开了所述化合物及其盐的制备方法以及将其用于制备治疗纤维化药物的用途。从三氟甲基吡啶酮为起始材料获得了新的吡啶类化合物及其盐。

  公开号：

  US08377932B2

文献信息

• PREPARATION OF 1-(SUBSTITUTED BENZYL)-5-TRIFLUOROMETHYL-2(1H)PYRIDONE COMPOUNDS AND SALTS THEREOF AND THEIR APPLICATIONS
  申请人：Hu Gaoyun

  公开号：US20120129859A1

  公开（公告）日：2012-05-24

  1-(substituted benzyl)-5-trifluoromethyl-2(1H)pyridone compounds and their pharmaceutical acceptable salts are disclosed. The preparation methods of the compounds and their salts and the use of the same for preparing the medicaments for treating fibrosis are also disclosed. New pyridine compounds and their salts are obtained from trifluoromethyl pyridone as starting material.

  揭示了1-(取代苄基)-5-三氟甲基-2(1H)吡啶酮化合物及其药用可接受盐。还公开了这些化合物及其盐的制备方法，以及用于制备治疗纤维化药物的用途。从三氟甲基吡啶酮作为起始物获得了新的吡啶化合物及其盐。
• 1-(SUBSTITUTED BENZYL)-5-TRIFLUOROMETHYL-2-(1H) PYRIDONE COMPOUNDS AND THEIR SALTS, THEIR PREPARATION METHODS AND USE THEREOF
  申请人：Central South University

  公开号：EP2474533A1

  公开（公告）日：2012-07-11

  1-(substituted benzyl)-5-trifluoromethyl-2(1H)pyridone compounds and their pharmaceutical acceptable salts are disclosed. The preparation methods of the compounds and their salts and the use of the same for preparing the medicaments for treating fibrosis are also disclosed. New pyridine compounds and their salts are obtained from trifluoromethyl pyridone as starting material.

  本发明公开了 1-(取代苄基)-5-三氟甲基-2(1H)吡啶酮化合物及其药用盐。此外，还公开了这些化合物及其盐的制备方法和用于制备治疗纤维化药物的用途。以三氟甲基吡啶酮为起始原料，可获得新的吡啶化合物及其盐。
• PREPARATION OF 1-(SUBSTITUTED BENZYL)-5-TRIFLUOROMETHYL-2-(1H)PYRIDONE COMPOUNDS AND SALTS THEREOF AND THEIR APPLICATIONS
  申请人：Central South University

  公开号：EP2474533B1

  公开（公告）日：2015-02-25
• US8377932B2
  申请人：——

  公开号：US8377932B2

  公开（公告）日：2013-02-19
• Preparation of 1-(substituted benzyl)-5-trifluoromethyl-2(1H)pyridone compounds and salts thereof and their applications
  申请人：Hu Gaoyun

  公开号：US08377932B2

  公开（公告）日：2013-02-19

  1-(substituted benzyl)-5-trifluoromethyl-2(1H)pyridone compounds and their pharmaceutical acceptable salts are disclosed. The preparation methods of the compounds and their salts and the use of the same for preparing the medicaments for treating fibrosis are also disclosed. New pyridine compounds and their salts are obtained from trifluoromethyl pyridone as starting material.

  本发明公开了1-(取代苯基)-5-三氟甲基-2(1H)吡啶酮类化合物及其药学上可接受的盐。本发明还公开了所述化合物及其盐的制备方法以及将其用于制备治疗纤维化药物的用途。从三氟甲基吡啶酮为起始材料获得了新的吡啶类化合物及其盐。