Tert-butyl 3-chloro-3'-iodo-2-methyl-5-oxospiro[furo[3,4-b]pyridine-7,4'-piperidine]-1'-carboxylate | 934361-43-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: Tert-butyl 3-chloro-3'-iodo-2-methyl-5-oxospiro[furo[3,4-b]pyridine-7,4'-piperidine]-1'-carboxylate
• CAS: 934361-43-0
• 化学式: C₁₇H₂₀ClIN₂O₄
• 分子量: 478.714
• InChiKey: LGUBEHQAXXBXMB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  25
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  68.7
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Tert-butyl 3-chloro-3'-iodo-2-methyl-5-oxospiro[furo[3,4-b]pyridine-7,4'-piperidine]-1'-carboxylate 在 偶氮二异丁腈 、 三正丁基氢锡 作用下， 以 甲苯 为溶剂， 以96.6%的产率得到tert-butyl 3-chloro-2-methyl-5-oxo-5H-spiro[furo[3,4-b]pyridine-7,4'-piperidine]-1'-carboxylate
  参考文献：
  名称：

  Preparation of 3,4-fused-spiro[furan-5(5H),4′-piperidin]-2-one

  摘要：

  A general method for the preparation of various 3,4-fused-spiro[furan-5(5H),4'-piperidini-2-one with high yield is reported. The formation of spiro[furarione-piperidine] structure was achieved by a Suzuki coupling, followed by an iodolactonization reaction. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.07.035
• 作为产物：
  描述：

  5-chloro-6-methyl-2-[1-[(2-methylpropan-2-yl)oxycarbonyl]-3,6-dihydro-2H-pyridin-4-yl]pyridine-3-carboxylic acid 在 碘 、 碳酸氢钠 、 potassium iodide 作用下， 以 水 、 乙腈 为溶剂， 反应 18.0h， 以85%的产率得到Tert-butyl 3-chloro-3'-iodo-2-methyl-5-oxospiro[furo[3,4-b]pyridine-7,4'-piperidine]-1'-carboxylate
  参考文献：
  名称：

  Preparation of 3,4-fused-spiro[furan-5(5H),4′-piperidin]-2-one

  摘要：

  A general method for the preparation of various 3,4-fused-spiro[furan-5(5H),4'-piperidini-2-one with high yield is reported. The formation of spiro[furarione-piperidine] structure was achieved by a Suzuki coupling, followed by an iodolactonization reaction. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.07.035

文献信息

• [EN] ACYLATED SPIROPIPERIDINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR MODULATORS<br/>[FR] DERIVES SPIROPIPERIDINES ACYLES CONVENANT COMME MODULATEURS DES RECEPTEURS DE LA MELANOCORTINE-4
  申请人：MERCK & CO INC

  公开号：WO2007041052A3

  公开（公告）日：2007-05-31
• ACYLATED SPIROPIPERIDINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR MODULATORS
  申请人：Merck Sharp & Dohme Corp.

  公开号：EP1940842B1

  公开（公告）日：2012-05-30
• Acylated Spiropiperidine Derivatives as Melanocortin-4 Receptor Modulators
  申请人：Jian Tianying

  公开号：US20090170863A1

  公开（公告）日：2009-07-02

  Certain novel N-acylated spiropiperidine derivatives are ligands of the human melanocortin receptor(s) and, in particular, are selective ligands of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of MC-4R, such as obesity, diabetes, nicotine addiction, alcoholism, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.
• US8293900B2
  申请人：——

  公开号：US8293900B2

  公开（公告）日：2012-10-23