N-(4-chlorophenethyl)-2-(3,5-dimethylphenyl)-4-(4-methoxy-3-nitrophenyl)thiazol-5-amine | 1187843-55-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(4-chlorophenethyl)-2-(3,5-dimethylphenyl)-4-(4-methoxy-3-nitrophenyl)thiazol-5-amine
• 英文别名: N-[2-(4-chlorophenyl)ethyl]-2-(3,5-dimethylphenyl)-4-(4-methoxy-3-nitrophenyl)-1,3-thiazol-5-amine
• CAS: 1187843-55-5
• 化学式: C₂₆H₂₄ClN₃O₃S
• 分子量: 494.014
• InChiKey: PSXGJZFLEPQPIG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.7
• 重原子数：
  34
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  108
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  N-(4-chlorophenethyl)-2-(3,5-dimethylphenyl)-4-(4-methoxy-3-nitrophenyl)thiazol-5-amine 、 对氟苯甲酰氯 在 4-二甲氨基吡啶 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 24.0h， 以114 mg的产率得到N-(4-chlorophenethyl)-N-(2-(3,5-dimethylphenyl)-4-(4-methoxy-3-nitrophenyl)thiazol-5-yl)-4-fluorobenzamide
  参考文献：
  名称：

  Ugi Reactions with Ammonia Offer Rapid Access to a Wide Range of 5-Aminothiazole and Oxazole Derivatives

  摘要：

  A series of Ugi reactions has been successfully performed using ammonia as the amine component, employing 2,2,2-trifluoroethanol its a non-nucleophilic solvent in order to suppress known side reactions. Utilizing concentrated aqueous ammonia its it convenient Source, this approach offered a simple, one-step assembly of Ugi adducts suitable for elaboration into it variety of 5-aminoazole compounds through postcondensation modifications. Free or N-substituted 5-aminothiazoles and 5-(trifluoroacetamido)oxazoles were all prepared by this improved methodology. The scope of the synthetic route developed and application of the different products are discussed.

  DOI：

  10.1021/jo9014529
• 作为产物：
  描述：

  N-(2-(4-chlorophenethylamino)-1-(4-methoxy-3-nitrophenyl)-2-oxoethyl)-3,5-dimethylbenzamide 在 劳森试剂 作用下， 以 甲苯 为溶剂， 反应 1.0h， 生成 N-(4-chlorophenethyl)-2-(3,5-dimethylphenyl)-4-(4-methoxy-3-nitrophenyl)thiazol-5-amine
  参考文献：
  名称：

  Ugi Reactions with Ammonia Offer Rapid Access to a Wide Range of 5-Aminothiazole and Oxazole Derivatives

  摘要：

  A series of Ugi reactions has been successfully performed using ammonia as the amine component, employing 2,2,2-trifluoroethanol its a non-nucleophilic solvent in order to suppress known side reactions. Utilizing concentrated aqueous ammonia its it convenient Source, this approach offered a simple, one-step assembly of Ugi adducts suitable for elaboration into it variety of 5-aminoazole compounds through postcondensation modifications. Free or N-substituted 5-aminothiazoles and 5-(trifluoroacetamido)oxazoles were all prepared by this improved methodology. The scope of the synthetic route developed and application of the different products are discussed.

  DOI：

  10.1021/jo9014529

文献信息

• Ugi Reactions with Ammonia Offer Rapid Access to a Wide Range of 5-Aminothiazole and Oxazole Derivatives
  作者：Mark J. Thompson、Beining Chen

  DOI：10.1021/jo9014529

  日期：2009.9.18

  A series of Ugi reactions has been successfully performed using ammonia as the amine component, employing 2,2,2-trifluoroethanol its a non-nucleophilic solvent in order to suppress known side reactions. Utilizing concentrated aqueous ammonia its it convenient Source, this approach offered a simple, one-step assembly of Ugi adducts suitable for elaboration into it variety of 5-aminoazole compounds through postcondensation modifications. Free or N-substituted 5-aminothiazoles and 5-(trifluoroacetamido)oxazoles were all prepared by this improved methodology. The scope of the synthetic route developed and application of the different products are discussed.