2-amino-6-bromo-3-methylbenzoic acid | 1156838-26-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-amino-6-bromo-3-methylbenzoic acid
• CAS: 1156838-26-4
• 化学式: C₈H₈BrNO₂
• mdl: MFCD12096465
• 分子量: 230.061
• InChiKey: CFYMUCDDZDMONG-UHFFFAOYSA-N

物化性质

• 沸点：
  355.6±42.0 °C(Predicted)
• 密度：
  1.682±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.125
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-amino-6-bromo-3-methylbenzoic acid 在 盐酸 、 4-二甲氨基吡啶 、 三乙胺 、 N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 3.33h， 生成 5-bromo-8-methyl-3-(2-(trifluoromethyl)benzyl)benzo[d][1,2,3]triazin-4(3H)-one
  参考文献：
  名称：

  [EN] 2-SUBSTITUTED THIAZOLE HSD17B13 INHIBITORS AND USES THEREOF
  [FR] INHIBITEURS THIAZOLES 2-SUBSTITUÉS DE HSD17B13 ET UTILISATIONS ASSOCIÉES

  摘要：

  Described herein are selective HSD17B13 inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of liver disease, metabolic disease, or cardiovascular disease, such as NAFLD or NASH, or drug induced liver injury (DILI).

  公开号：

  WO2023146897A1

文献信息

• POLYMERIZABLE COMPOUND AND OPTICALLY ANISOTROPIC BODY
  申请人：DIC Corporation

  公开号：US20170362508A1

  公开（公告）日：2017-12-21

  A problem of the present invention is to provide a polymerizable compound and a polymerizable composition which cause little decrease in retardation and discoloration when a film-shaped polymer produced by polymerization is irradiated with ultraviolet/visible light for a long time at high temperature. A further problem is to provide a polymer produced by polymerizing the polymerizable composition and an optically anisotropic body using the polymer. As a result, a compound useful as a component of a polymerizable composition was obtained. An optically anisotropic body using a polymerizable liquid crystal composition containing the compound of the present invention is useful for application to an optical film and the like.