coprinol | 1197922-03-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: coprinol
• 英文别名: 6-(2-hydroxyethyl)-2,2,5,7-tetramethyl-1,3-dihydroinden-4-ol
• CAS: 1197922-03-4
• 化学式: C₁₅H₂₂O₂
• 分子量: 234.338
• InChiKey: GCMUHPCLXBXQDH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-(2,2,4,6-tetramethylindan-5-yl)ethanol 在 邻苯二甲酰过氧化物 作用下， 以76 %的产率得到coprinol
  参考文献：
  名称：

  区域选择性 [2 + 2 + 2] 炔烃环三聚合成鬼伞酚和几种紫杉醇倍半萜烯

  摘要：

  炔烃 [2 + 2 + 2] 环三聚是合成高取代苯环的一种具有战略吸引力但在战术上具有挑战性的方法。在这里，将双分子区域选择性环三聚化应用于天然产物鸡公醇和来自倍半萜类 illudalane 家族的几种相关 alcyopterosins 的全合成。由双甲酮合成鸡芹醇分六步完成，总收率为 57%。替代官能团操作导致 alcyopterosins A、B 和 O 以及另外两个同系物，所有这些都在六个步骤中。

  DOI：

  10.1021/acs.joc.2c01741

文献信息

• Total Synthesis of Coprinol
  作者：Muthiah Suresh、Navin Kumar、Gorre Veeraraghavaiah、Sunit Hazra、Raj Bahadur Singh

  DOI：10.1021/acs.jnatprod.6b00277

  日期：2016.10.28

  The first synthesis of coprinol has been achieved from 2-methoxy-3,5-dimethylbenzaldehyde via the intermediacy of an indanone derivative where dialkylation, Friedel–Crafts acylation, demethylation, and regioselective formation of a primary −OH group from a chloroacetyl group are the key steps.

  通过茚满酮衍生物的中间体，从2-甲氧基-3,5-二甲基苯甲醛中完成了coprinol的首次合成，其中二氯化，Friedel-Crafts酰化，去甲基化和由氯乙酰基形成伯-OH基的区域选择性关键步骤。
• THE PHARMACEUTICAL COMPOSITIONS FOR PREVENTION OR TREATMENT OF INFLAMMATORY SPINE DISEASE CONTAINING SCOLOPENDRA SUBSPINIPES AND PEONY AS AN ACTIVE INGREDIENT
  申请人：Shin, Joon Shik

  公开号：EP3360563B1

  公开（公告）日：2019-04-03
• Pharmaceutical Compound For Treating Inflammation, Pain, Arthritis And Spinitis, And Proliferating Osteoblastic Cell And Method For Producing Thereof
  申请人：Shin Jun- Sik

  公开号：US20090226544A1

  公开（公告）日：2009-09-10

  The present invention relates to a pharmaceutical composition having efficacy in the treatment of inflammation, pain, arthritis and spinitis, and the proliferation and activity of ost eoblastic cells, and a preparation method thereof. The present invention provides a pharmaceutical composition comprising pharmaceutically effective components extracted from Cibotii Rhizoma, Ledebouriellae Radix, Achyranthes bidentatae Radix, Acanthopanacis Cortex, Eucommiae Cortex, and Glycine Semen nigra, and a preparation method thereof. The pharmaceutically effective components may be extracted using hot water, an organic solvent, or a mixed solvent thereof. Alternatively, the pharmaceutically effective components may be prepared by a UF membrane to have a molecular weight of not greater than 10,000.
• PTEROSIN DERIVATIVE-CONTAINING THERAPEUTIC PREPARATION FOR DISEASE ASSOCIATED WITH CARTILAGE LOSS, CARTILAGE DEGENERATION AND/OR CARTILAGE THINNING
  申请人：KYOTO UNIVERSITY

  公开号：US20150051293A1

  公开（公告）日：2015-02-19

  An object of the present invention is to provide a therapeutic preparation and method for diseases associated with cartilage loss, cartilage degeneration and/or cartilage thinning. The present invention provides a therapeutic preparation comprising a pterosin derivative or a pharmaceutically acceptable salt thereof for diseases associated with cartilage loss, cartilage degeneration and/or cartilage thinning; and a therapeutic method for the diseases.
• US6531582B1
  申请人：——

  公开号：US6531582B1

  公开（公告）日：2003-03-11