(RS)-[1-(2-benzyloxy-ethyl)-1H-benzoimidazol-2-yl]-methoxy-acetic acid | 854763-19-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: (RS)-[1-(2-benzyloxy-ethyl)-1H-benzoimidazol-2-yl]-methoxy-acetic acid
• 英文别名: 2-methoxy-2-[1-(2-phenylmethoxyethyl)benzimidazol-2-yl]acetic acid
• CAS: 854763-19-2
• 化学式: C₁₉H₂₀N₂O₄
• 分子量: 340.379
• InChiKey: QURXNFJIDVQDCY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  25
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  73.6
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (RS)-[1-(2-benzyloxy-ethyl)-1H-benzoimidazol-2-yl]-methoxy-acetic acid 、 benzyl N-[4-(aminomethyl)benzenecarboximidoyl]carbamate;dihydrochloride 以to give (RS)-[1-amino-1-[4-({2-[1-(2-benzyloxy-ethyl)-1H-benzoimidazol-2-yl]-2-methoxy-acetylamino}-methyl)-phenyl]-meth-(Z)-ylidene]-carbamic acid benzyl ester的产率得到(RS)-[1-amino-1-[4-({2-[1-(2-benzyloxy-ethyl)-1H-benzoimidazol-2-yl]-2-methoxy-acetylamino}-methyl)-phenyl]-meth-(Z)-ylidene]-carbamic acid benzyl ester
  参考文献：
  名称：

  Heterocyclyl substituted 1-alkoxy acetic acid amides

  摘要：

  本发明涉及公式(I)的新型杂环基取代的1-烷氧基乙酸衍生物，其中R1至R6和A如说明书和权利要求中所定义，并且其生理上可接受的盐。这些化合物抑制因子VIIa和组织因子诱导的凝血因子Xa、IXa和凝血酶的形成，可用作药物。

  公开号：

  US07056932B2

文献信息

• AMINO SUBSTITUTED DIARYL [A,D]CYCLOHEPTENE ANALOGS AS MUSCARINIC AGONISTS AND METHODS OF TREATMENT OF NEUROPSYCHIATRIC DISORDERS
  申请人：Acadia Pharmaceuticals Inc.

  公开号：EP1696931A2

  公开（公告）日：2006-09-06
• N-(4-CARBAMIMIDOYL-BENZYL)-2-ALKOXY-2-HETEROCYCLYL ACETAMIDES AS INHIBITORS OF THE FORMATION OF COAGULATION FACTORS XA, IXA AND THROMBIN INDUCED BY FACTOR VIIA
  申请人：F.HOFFMANN-LA ROCHE AG

  公开号：EP1706396A1

  公开（公告）日：2006-10-04
• US7056932B2
  申请人：——

  公开号：US7056932B2

  公开（公告）日：2006-06-06
• [EN] N-(4-CARBAMIMIDOYL-BENZYL) -2-ALKOXY-2-HETEROCYCLYL ACETAMIDES AS INHIBITORS OF THE FORMATION OF COAGULATION FACTORS XA, IXA AND THROMBIN INDUCED BY FACTOR VIIA<br/>[FR] ACETAMIDES DE N-(4-CARBAMIMIDOYL-BENZYL) -2-ALKOXY-2-HETEROCYCLYLE UTILISES EN TANT QU'INHIBITEURS DE LA FORMATION DE FACTEURS DE COAGULATION XA, IXA ET THROMBINE INDUITS PAR LE FACTEUR VIIA
  申请人：HOFFMANN LA ROCHE

  公开号：WO2005058868A1

  公开（公告）日：2005-06-30

  The invention is concerned with novel heterocyclyl substituted mandelic acid derivatives of formula (I) wherein R1 to R6 and A are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit the formation of coagulation factors Xa, IXa and thrombin induced by factor VIIa and tissue factor and can be used as medicaments.
• [EN] AMINO SUBSTITUTED DIARYL[A,D]CYCLOHEPTENE ANALOGS AS MUSCARINIC AGONISTS AND METHODS OF TREATMENT OF NEUROPSYCHIATRIC DISORDERS<br/>[FR] ANALOGUES DE DIARYL[A,D]CYCLOHEPTENE AMINO SUBSTITUES UTILISES COMME AGONISTES MUSCARINIQUES, ET PROCEDES DE TRAITEMENT DE TROUBLES NEUROPSYCHIATRIQUES
  申请人：ACADIA PHARM INC

  公开号：WO2005063254A2

  公开（公告）日：2005-07-14

  Disclosed herein are analogs of clozapine and pharmaceutically acceptable salts, esters, amides, or prodrugs thereof; methods of synthesizing the analogs; and methods of using the analogs for treating neuorpsychiatric disorders. In some embodiments, the analogs are amino substituted diaryl[a,d]cycloheptenes.