2-(Pyridine-2-sulfonyl)ethan-1-amine hydrochloride | 947662-84-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-(Pyridine-2-sulfonyl)ethan-1-amine hydrochloride
• 英文别名: 2-pyridin-2-ylsulfonylethanamine;hydrochloride
• CAS: 947662-84-2
• 化学式: C₇H₁₀N₂O₂S*ClH
• 分子量: 222.696
• InChiKey: ZLDMOCOJQVRCHX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.24
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  81.4
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(Pyridine-2-sulfonyl)ethan-1-amine hydrochloride 、 4-氯苯甲酰氯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 4-chloro-N-(2-pyridin-2-ylsulfonylethyl)benzamide
  参考文献：
  名称：

  Identification and Characterization of 4-Chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide (GSK3787), a Selective and Irreversible Peroxisome Proliferator-Activated Receptor δ (PPARδ) Antagonist

  摘要：

  4-Chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide 3 (GSK3787) was identified as a potent and selective ligand for PPAR delta wish good pharmacokinetic properties. A detailed binding study using mass spectral analysis confirmed covalent binding to Cys249 within the PPAR delta binding pocket. Gene expression studies showed that pyridylsulfone 3 antagonized the transcriptional activity of PPAR delta and inhibited basal CPT1a gene transcription. Compound 3 is a PPAR delta antagonist with utility as it tool to elucidate PPAR delta cell biology and pharmacology.

  DOI：

  10.1021/jm900464j
• 作为产物：
  描述：

  tert-butyl (2-(pyridin-2-ylsulfonyl)ethyl)carbamate 在 盐酸 、 水 作用下， 以 1,4-二氧六环 为溶剂， 反应 3.0h， 生成 2-(Pyridine-2-sulfonyl)ethan-1-amine hydrochloride
  参考文献：
  名称：

  Identification and Characterization of 4-Chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide (GSK3787), a Selective and Irreversible Peroxisome Proliferator-Activated Receptor δ (PPARδ) Antagonist

  摘要：

  4-Chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide 3 (GSK3787) was identified as a potent and selective ligand for PPAR delta wish good pharmacokinetic properties. A detailed binding study using mass spectral analysis confirmed covalent binding to Cys249 within the PPAR delta binding pocket. Gene expression studies showed that pyridylsulfone 3 antagonized the transcriptional activity of PPAR delta and inhibited basal CPT1a gene transcription. Compound 3 is a PPAR delta antagonist with utility as it tool to elucidate PPAR delta cell biology and pharmacology.

  DOI：

  10.1021/jm900464j

文献信息

• Anilinoquinazaolines as protein tyrosine kianse inhibitors
  申请人：Cockerill Stuart George

  公开号：US20050143401A1

  公开（公告）日：2005-06-30

  Heteroaromatic compounds are described, methods for their preparation, pharmaceutical compositions containing them, methods of use, and their use in medicines. In particular, the invention relates to quinazoline and pyridopyrimidine derivatives which exhibit protein tyrosine kinase inhibition.

  本发明描述了杂环芳香化合物，它们的制备方法，含有它们的药物组合物，使用方法以及它们在药物中的应用。特别是，本发明涉及表现出蛋白酪氨酸激酶抑制活性的喹唑啉和吡啶嘧啶衍生物。
• HETEROCYCLIC COMPOUNDS
  申请人：Cockerill Stuart George

  公开号：US20080004294A1

  公开（公告）日：2008-01-03

  Heteroaromatic compounds are described, methods for their preparation, pharmaceutical compositions containing them, methods of use, and their use in medicines. In particular, the invention relates to quinazoline and pyridopyrimidine derivatives which exhibit protein tyrosine kinase inhibition.

  本发明涉及杂环芳香化合物、其制备方法、含有它们的药物组合物、使用方法以及它们在药物中的应用。特别地，本发明涉及能够抑制蛋白酪氨酸激酶的喹嗪啉和吡啶并嘧啶衍生物。
• FUSED NITROGEN-COMPRISING HETEROCYCLIC COMPOUND
  申请人：Seto Masaki

  公开号：US20100234351A1

  公开（公告）日：2010-09-16

  A compound of the formula: wherein ring A is a 7-membered or 8-membered nitrogen-containing ring optionally further substituted, ring B is an optionally substituted aryl group or an optionally substituted heteroaryl group, X 1 is a group represented by —NR 3 —Y 1 —, —O—, —S—, —SO—, —SO 2 — or —CHR 3 — wherein R 3 is a hydrogen atom or an optionally substituted aliphatic hydrocarbon group, or R 3 may be bonded to the carbon atom of ring B to form an optionally substituted ring structure, and Y 1 is a bond or an optionally substituted alkylene, R 1 is a hydrogen atom, or an optionally substituted group bonded via a carbon atom or a sulfur atom, the formula shows a single bond or a double bond, when R 2 is —R 2 , R 2 is a hydrogen atom, or an optionally substituted group bonded via a carbon atom, a nitrogen atom, an oxygen atom or a sulfur atom, and when R 2 is ═R 2 , R 2 is an oxo group, an optionally substituted alkylidene group, or an optionally substituted imino group.

  该化合物的化学式为：其中环A是一个7-或8-成员的含氮环，可选择进一步取代，环B是一个可选择取代的芳基或杂芳基，X1是一个由—NR3—Y1—、—O—、—S—、—SO—、—SO2—或—CHR3—表示的基团，其中R3是氢原子或可选择取代的脂肪烃基团，或R3可与环B的碳原子结合形成可选择取代的环结构，Y1是一个键或可选择取代的烷基，R1是氢原子或通过碳原子或硫原子结合的可选择取代的基团，化学式中显示单键或双键，当R2是—R2时，R2是氢原子或通过碳原子结合的可选择取代的基团，氮原子、氧原子或硫原子，当R2是═R2时，R2是一个氧代基团、可选择取代的烷基亚甲基基团或可选择取代的亚胺基团。
• ANILINOQUINAZOLINES AS PROTEIN TYROSINE KINASE INHIBITORS
  申请人：GLAXO GROUP LIMITED

  公开号：EP1192151A1

  公开（公告）日：2002-04-03
• FUSED HETEROCYCLIC COMPOUND
  申请人：Takeda Pharmaceutical Company Limited

  公开号：EP1987037A2

  公开（公告）日：2008-11-05