N-methyl-3-amino-4-methylbenzamide hydrochloride | 621685-65-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-methyl-3-amino-4-methylbenzamide hydrochloride
• 英文别名: 3-amino-N-methyl-4-methylbenzamide hydrochloride；3-amino-N,4-dimethylbenzamide hydrochloride；3-amino-N,4-dimethylbenzamide;hydrochloride
• CAS: 621685-65-2
• 化学式: C₉H₁₂N₂O*ClH
• 分子量: 200.668
• InChiKey: KUWIAANVRNLPBO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.36
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  55.1
• 氢给体数：
  3
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-methyl-3-amino-4-methylbenzamide hydrochloride 、 (2E)-3-methoxy-2-propenoyl chloride 在 吡啶 作用下， 以 丙酮 为溶剂， 反应 1.0h， 以78%的产率得到3-[[(E)-3-methoxyprop-2-enoyl]amino]-N,4-dimethylbenzamide
  参考文献：
  名称：

  [EN] PROCESS FOR PREPARING 2-AMINOTHIAZOLE-5-AROMATIC CARBOXAMIDES AS KINASE INHIBITORS
  [FR] PROCEDE DE PREPARATION DE CARBOXAMIDES 2-AMINOTHIAZOLE-5-AROMATIQUES UTILES COMME INHIBITEURS DE KINASES

  摘要：

  公开号：

  WO2005077945A3

文献信息

• [EN] PHENYL-ANILINE SUBSTITUTED BICYCLIC COMPOUNDS USEFUL AS KINASE INHIBITORS<br/>[FR] COMPOSES BICYCLIQUES A SUBSTITUTION PHENYL-ANILINE UTILISES COMME INHIBITEUR DE LA KINASE
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2005042537A1

  公开（公告）日：2005-05-12

  Compounds having the formula (I), and pharmaceutically acceptable salts, prodrugs, and solvates thereof, are useful as kinase inhibitors, wherein R, R1 , R2, R5, R6a, R6b, J, K, X and Z are as described in the specification.

  具有化学式（I）的化合物，以及其药学上可接受的盐、前药和溶剂化合物，可用作激酶抑制剂，其中R、R1、R2、R5、R6a、R6b、J、K、X和Z如规范中所述。
• Process for preparing 2-aminothiazole-5-carboxamides useful as kinase inhibitors
  申请人：Chen Bang-Chi

  公开号：US20050176965A1

  公开（公告）日：2005-08-11

  The invention is directed to processes for preparing 2-aminothiazole-5-carboxamides of formula I wherein R 1 , R 2 , R 3 , R 4 and R 5 are as defined as set forth in the specification herein.

  这项发明涉及制备式I的2-氨基噻唑-5-羧酰胺的过程 其中R1、R2、R3、R4和R5如本规范中所定义。
• Aryl ketone pyrrolo-triazine compounds useful as kinase inhibitors
  申请人：——

  公开号：US20030232831A1

  公开（公告）日：2003-12-18

  Compounds having the formula (I), 1 and pharmaceutically acceptable salts, prodrugs, and solvates thereof, are surprisingly advantageous as p38 kinase inhibitors, wherein R 3 is hydrogen, methyl, perfluoromethyl, methoxy, halogen, cyano, NH 2 , or NH(CH 3 ), preferably methyl; X is N or CH; and R 1 through R 6 are as described in the specification.

  具有化学式（I）的化合物及其药学上可接受的盐、前药和溶剂化合物，作为p38激酶抑制剂具有出乎意料的优势，其中R3是氢、甲基、全氟甲基、甲氧基、卤素、氰基、NH2或NH（CH3），优选甲基；X是N或CH；R1至R6如说明书中所述。
• PROCESS FOR PREPARING 2-AMINOTHIAZOLE-5-AROMATIC CARBOXAMIDES AS KINASE INHIBITORS
  申请人：Chen Bang-Chi

  公开号：US20090149650A1

  公开（公告）日：2009-06-11

  The invention relates to processes for preparing compounds having the formula, and crystalline forms thereof, wherein Ar is aryl or heteroaryl, L is an optional alkylene linker, and R 2 , R 3 , R 4 , and R 5 , are as defined in the specification herein, which compounds are useful as kinase inhibitors, in particular, inhibitors of protein tyrosine kinase and p38 kinase.

  本发明涉及制备具有以下公式及其结晶形式的化合物的方法，其中Ar是芳基或杂环芳基，L是可选的烷基链，R2、R3、R4和R5如本说明书中所定义的，这些化合物可用作激酶抑制剂，特别是蛋白酪氨酸激酶和p38激酶的抑制剂。
• Process for preparing 2-aminothiazole-5-aromatic carboxamides as kinase inhibitors
  申请人：Chen Bang-Chi

  公开号：US20060004067A1

  公开（公告）日：2006-01-05

  The invention relates to processes for preparing compounds having the formula, and crystalline forms thereof, wherein Ar is aryl or heteroaryl, L is an optional alkylene linker, and R 2 , R 3 , R 4 , and R 5 , are as defined in the specification herein, which compounds are useful as kinase inhibitors, in particular, inhibitors of protein tyrosine kinase and p38 kinase.

  本发明涉及制备具有下列公式和其晶体形式的化合物的方法，其中Ar为芳基或杂环芳基，L为可选的烷基连接器，R2、R3、R4和R5如本说明书中所定义，这些化合物可用作激酶抑制剂，特别是蛋白酪氨酸激酶和p38激酶的抑制剂。