α-(3,4-dihydroxybenzamido)-3,4-dihydroxycinnamic acid 3,4-dihydroxybenzylamide | 633699-88-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: α-(3,4-dihydroxybenzamido)-3,4-dihydroxycinnamic acid 3,4-dihydroxybenzylamide
• 英文别名: alpha-(3,4-Dihydroxybenzamido)-3,4-dihydroxycinnamic acid 3,4-dihydroxybenzylamide；N-[1-(3,4-dihydroxyphenyl)-3-[(3,4-dihydroxyphenyl)methylamino]-3-oxoprop-1-en-2-yl]-3,4-dihydroxybenzamide
• CAS: 633699-88-4
• 化学式: C₂₃H₂₀N₂O₈
• 分子量: 452.42
• InChiKey: RDKZISZYXBXPQK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  33
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  180
• 氢给体数：
  8
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  、 3.4.3'.4'-Tetrahydroxy-bibenzyl 、 N,N'-bis(3,4-dihydroxybenzyl)-trans-1,2-diaminocyclohexane 、 α-(3,4-dihydroxybenzamido)-3,4-dihydroxycinnamic acid 3,4-dihydroxybenzylamide 、 、 bis(3,4-dihydroxybenzyl)amine 、 1,3-bis(3,4-dihydroxyphenyl)urea 、 1-(3,4-dihydroxyphenyl)-3-(3,4-dihydroxyphenethyl) urea 生成 3,3',4,4'-Tetrahydroxy-benzoin
  参考文献：
  名称：

  Compounds, compositions and methods for the treatment of amyloid diseases and synucleinopathies such as alzheimer's disease, type 2 diabetes, and parkinson's disease

  摘要：

  双和三羟基芳基化合物及其甲氧基二氧杂环丙基类似物和药学上可接受的酯，其合成，含有它们的制药组合物，以及它们在治疗淀粉样疾病中的应用，特别是在阿尔茨海默病中观察到的Aβ淀粉样蛋白病，如在2型糖尿病中观察到的IAPP淀粉样蛋白病和突触核蛋白病，如在帕金森病中观察到的，并且制造用于这种治疗的药物。

  公开号：

  US07514583B2
• 作为产物：
  描述：

  α-(3,4-methylenedioxybenzamido)-3,4-methylenedioxycinnamic acid 3,4-methylenedioxybenzylamide 在 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以53%的产率得到α-(3,4-dihydroxybenzamido)-3,4-dihydroxycinnamic acid 3,4-dihydroxybenzylamide
  参考文献：
  名称：

  [EN] COMPOUNDS, COMPOSITIONS AND METHODS FOR THE TREATMENT OF AMYLOID DISEASES AND SYNUCLEINOPATHIES SUCH AS ALZHEIMER'S DISEASE, TYPE 2 DIABETES, AND PARKINSON'S DISEASE
  [FR] COMPOSES, COMPOSITIONS ET PROCEDES DE TRAITEMENT DE MALADIES AMYLOIDES ET DE SYNUCLEINOPATHIES, NOTAMMENT DE LA MALADIE D'ALZHEIMER, DU DIABETE DE TYPE 2 ET DE LA MALADIE DE PARKINSON

  摘要：

  双-和三-二羟基芳基化合物及其亚甲二氧基类似物和药用可接受酯，它们的合成，含有它们的药物组合物，以及它们在治疗淀粉样疾病，特别是Aß淀粉样病变，如阿尔茨海默病中观察到的，IAPP淀粉样病变，如2型糖尿病中观察到的，以及α-突触核病，如帕金森病中观察到的，以及用于制造用于此类治疗的药物。

  公开号：

  WO2003101927A1

文献信息

• Compounds, compositions and methods for the treatment of inflammatory diseases
  申请人：Sanders J. Virginia

  公开号：US20070208087A1

  公开（公告）日：2007-09-06

  The use of a composition comprising a compound: where R is a C 1 -C 10 alkylene group, in which, when the number of carbon atoms is at least 2, there are optionally 1 or 2 non-adjacent double bonds; 1 to 3 non-adjacent methylene groups are optionally replaced by NR 1 (where R 1 is H, alkyl, or acyl), O, or S; and 1 or 2 methylene groups are optionally replaced by a carbonyl or hydroxymethylene group for the preparation of a medicament or a pharmaceutical for the treatment of inflammatory diseases.

  使用含有化合物的组合物：其中R是C1-C10烷基基团，当碳原子数至少为2时，可以选则1或2个非相邻的双键；1到3个非相邻的亚甲基团可以被NR1（其中R1为H，烷基或酰基）、O或S替换；并且1或2个亚甲基团可以被羰基或羟甲基基团替换，以制备用于治疗炎症性疾病的药物或制剂。
• [EN] COMPOUNDS, COMPOSITIONS AND METHODS FOR THE TREATMENT OF AMYLOID DISEASES AND SYNUCLEINOPATHIES SUCH AS ALZHEIMER'S DISEASE, TYPE 2 DIABETES, AND PARKINSON'S DISEASE<br/>[FR] COMPOSES, COMPOSITIONS ET PROCEDES DE TRAITEMENT DE MALADIES AMYLOIDES ET DE SYNUCLEINOPATHIES, NOTAMMENT DE LA MALADIE D'ALZHEIMER, DU DIABETE DE TYPE 2 ET DE LA MALADIE DE PARKINSON
  申请人：PROTEOTECH INC

  公开号：WO2003101927A1

  公开（公告）日：2003-12-11

  Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially Aß amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinophathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.

  双-和三-二羟基芳基化合物及其亚甲二氧基类似物和药用可接受酯，它们的合成，含有它们的药物组合物，以及它们在治疗淀粉样疾病，特别是Aß淀粉样病变，如阿尔茨海默病中观察到的，IAPP淀粉样病变，如2型糖尿病中观察到的，以及α-突触核病，如帕金森病中观察到的，以及用于制造用于此类治疗的药物。
• Compounds, compositions and methods for the treatment of amyloid diseases and synucleinopathies such as alzheimer's disease, type 2 diabetes, and parkinson's disease
  申请人：Proteotech, Inc.

  公开号：US07514583B2

  公开（公告）日：2009-04-07

  Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.

  双和三羟基芳基化合物及其甲氧基二氧杂环丙基类似物和药学上可接受的酯，其合成，含有它们的制药组合物，以及它们在治疗淀粉样疾病中的应用，特别是在阿尔茨海默病中观察到的Aβ淀粉样蛋白病，如在2型糖尿病中观察到的IAPP淀粉样蛋白病和突触核蛋白病，如在帕金森病中观察到的，并且制造用于这种治疗的药物。