(3R,3aR,6R,6aR)-6-methylhexahydrofuro[3,2-b]furan-3-ol | 1172139-98-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃类
• 英文名称: (3R,3aR,6R,6aR)-6-methylhexahydrofuro[3,2-b]furan-3-ol
• 英文别名: (3R,3aR,6R,6aR)-3-methyl-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-6-ol
• CAS: 1172139-98-8
• 化学式: C₇H₁₂O₃
• 分子量: 144.17
• InChiKey: JUHJMRCPZRWQAM-DBRKOABJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  tert-butyldimethyl ((3R,3aS,6aR)-6-methylenehexahydrofuro[3.2-b]furan-3-yloxy)silane 在 palladium on activated charcoal 氢气 、 四丁基氟化铵 作用下， 以 乙酸乙酯 、 四氢呋喃 为溶剂， 反应 2.08h， 生成 (3R,3aR,6R,6aR)-6-methylhexahydrofuro[3,2-b]furan-3-ol 、 AT-101
  参考文献：
  名称：

  [EN] TETRAHYDROFURO (3, 2 -B) PYRROL- 3 -ONE DERIVATIVES AS INHIBITORS OF CYSTEINE PROTEINASES
  [FR] COMPOSÉS

  摘要：

  公开号：

  WO2009087379A3

文献信息

• [EN] TETRAHYDROFURO [3, 2-B] PYRROL-3-ONE DERIVATIVES AS INHIBITORS OF CYSTEINE PROTEASES<br/>[FR] DÉRIVÉS DE TÉTRAHYDROFURO[3,2-B]PYRROL-3-ONE COMME INHIBITEURS DE CYSTÉINE PROTÉASES
  申请人：AMURA THERAPEUTICS LTD

  公开号：WO2009144450A1

  公开（公告）日：2009-12-03

  A compound of formula (I), or a pharmaceutically acceptable salt, hydrate, complex or pro-drug thereof, wherein one of R1 and R2 is H, and the other is selected fromC1-8-alkyl, C3-6-cycloalkyl and C1-8-alkyl-C5-10-aryl; R3 is selected from tert-butyl, cyclopentyl and 1-methylcyclopentyl; R9 is selected from the following: (F). The invention further relates to pharmaceutical compositions comprising compounds of formula (I), and the use of such compounds in the treatment of various diseases.

  一种具有式（I）的化合物，或其药学上可接受的盐、水合物、络合物或前药，其中R1和R2中的一个是H，另一个选自C1-8-烷基、C3-6-环烷基和C1-8-烷基-C5-10-芳基；R3选自叔丁基、环戊基和1-甲基环戊基；R9选自以下内容：（F）。本发明还涉及包括式（I）化合物的药物组合物，以及利用这些化合物治疗各种疾病。
• INDOLE AND AZAINDOLE DERIVATIVE HAVING AMPK-ACTIVATING ACTIVITY
  申请人：SHIONOGI & CO., LTD

  公开号：US20150203450A1

  公开（公告）日：2015-07-23

  Disclosed is a compound which is useful as an AMPK activator. A compound represented by formula: or its pharmaceutically acceptable salt, wherein Y is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, or substituted or unsubstituted heterocyclyl; T is —CR 7 ═ or —N═; U is —CR 8 ═ or —N═; R 2 is hydrogen, halogen, cyano, nitro, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted acyl, substituted or unsubstituted carbamoyl, substituted or unsubstituted alkylthio, substituted or unsubstituted alkylsulfinyl, substituted or unsubstituted alkylsulfonyl, or substituted or unsubstituted alkyloxycarbonyl; R 3 is halogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted heterocyclyl, or the like; and R 4 , R 7 and R 8 are each independently hydrogen, halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted heterocyclyl, or the like.

  本申请公开了一种作为AMPK激活剂有用的化合物。一种由以下结构表示的化合物或其药学上可接受的盐，其中Y被取代或未取代的烷基，取代或未取代的烯基，取代或未取代的炔基，取代或未取代的芳基，取代或未取代的杂环芳基，取代或未取代的环烷基，取代或未取代的环烯基，或取代或未取代的杂环烷基；T为—CR7═或—N═；U为—CR8═或—N═；R2为氢，卤素，氰基，硝基，羧基，取代或未取代的烷基，取代或未取代的烯基，取代或未取代的酰基，取代或未取代的氨基甲酰基，取代或未取代的烷基硫基，取代或未取代的烷基亚砜基，取代或未取代的烷基砜基，或取代或未取代的烷氧羰基；R3为卤素，取代或未取代的烷基，取代或未取代的烯基，取代或未取代的炔基，取代或未取代的芳基，取代或未取代的杂环芳基，取代或未取代的环烷基，取代或未取代的环烯基，取代或未取代的杂环烷基，或类似物；且R4、R7和R8分别独立地为氢，卤素，羟基，氰基，硝基，羧基，取代或未取代的烷基，取代或未取代的烯基，取代或未取代的炔基，取代或未取代的芳基，取代或未取代的杂环芳基，取代或未取代的环烷基，取代或未取代的环烯基，取代或未取代的杂环烷基，或类似物。
• INDANE BISPHENOLS, POLYMERS DERIVED THEREFROM, AND METHODS OF USE THEREOF
  申请人：Schultz Hume Laura G.

  公开号：US20140061533A1

  公开（公告）日：2014-03-06

  Disclosed herein are indane bisphenol monomer units, and polymers derived from such monomer units. Also disclosed herein are blends including such polymers, articles made from such polymers and blends, methods of using such monomers, polymers, and blends, and processes for preparing such monomers, polymers, and blends.

  本发明涉及indane双酚单体单元以及由此类单体单元衍生的聚合物。本发明还涉及包括此类聚合物的混合物，由此类聚合物和混合物制成的物品，使用此类单体、聚合物和混合物的方法，以及制备此类单体、聚合物和混合物的工艺。
• [EN] NOVEL ACTIVATORS OF AMP-ACTIVATED PROTEIN KINASES<br/>[FR] NOUVEAUX ACTIVATEURS DE PROTÉINES KINASES ACTIVÉES PAR L'AMP
  申请人：DEBIOPHARM INTERNAT S A

  公开号：WO2016001224A1

  公开（公告）日：2016-01-07

  The present invention relates to a compound of structural Formula (I) or a salt thereof, which is useful as a direct AMPK activator. A further aspect of the present invention relates to use of said compound for the treatment of AMPK related diseases and to a pharmaceutical composition containing said compound.

  本发明涉及结构式(I)的化合物或其盐，其可作为直接的AMPK激活剂。本发明的另一个方面涉及使用该化合物治疗AMPK相关疾病以及含有该化合物的制药组合物。
• BISPHENOL POLYMER STRUCTURAL UNITS AND METHOD OF MAKING THE SAME
  申请人：Swaminathan Shubashree

  公开号：US20120149923A1

  公开（公告）日：2012-06-14

  Provided herein are isosorbide-based bisphenol polymer structural units and methods of making the same. These structural units may be polymerized with one or more other types of structural units to form polymers, such as polycarbonates.

  本文提供了基于异山梨醇的双酚聚合物结构单元及其制备方法。这些结构单元可以与一种或多种其他类型的结构单元聚合形成聚合物，如聚碳酸酯。