3-amino-2-isopropoxy-5-methylpyridine | 179677-12-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3-amino-2-isopropoxy-5-methylpyridine
• 英文别名: 5-Methyl-2-(propan-2-yloxy)pyridin-3-amine；5-methyl-2-propan-2-yloxypyridin-3-amine
• CAS: 179677-12-4
• 化学式: C₉H₁₄N₂O
• 分子量: 166.223
• InChiKey: TWYJQXFKXMEYBQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  48.1
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-amino-2-isopropoxy-5-methylpyridine 在 正丁基锂 、 四甲基乙二胺 、 碘 、 三乙胺 作用下， 以 乙醚 为溶剂， 反应 5.75h， 生成 2,2-dimethyl-N-(4-iodo-2-isopropoxy-5-methyl-3-pyridyl)-propanamide
  参考文献：
  名称：

  Metallation in connection with cross-coupling reactions. Coupling of hindered aryls for the synthesis of 4-phenylpyridines as part of Streptonigrin and Lavendamycin analogues

  摘要：

  The synthesis of the C-D ring system of Streptonigrin and Lavendamycin alkaloid analogues by cross-coupling under Suzuki's conditions has been studied. Steric hindrance is the main problem. It has been solved either by using strong bases or working in a sealed tube under pressure.

  DOI：

  10.1016/0022-328x(95)05979-y
• 作为产物：
  描述：

  2-isopropoxy-5-methyl-3-nitropyridine 在 palladium on activated charcoal 氢气 作用下， 以 乙醇 为溶剂， 以95%的产率得到3-amino-2-isopropoxy-5-methylpyridine
  参考文献：
  名称：

  Metallation in connection with cross-coupling reactions. Coupling of hindered aryls for the synthesis of 4-phenylpyridines as part of Streptonigrin and Lavendamycin analogues

  摘要：

  The synthesis of the C-D ring system of Streptonigrin and Lavendamycin alkaloid analogues by cross-coupling under Suzuki's conditions has been studied. Steric hindrance is the main problem. It has been solved either by using strong bases or working in a sealed tube under pressure.

  DOI：

  10.1016/0022-328x(95)05979-y

文献信息

• TYK2 INHIBITORS AND USES THEREOF
  申请人：Nimbus Lakshmi, Inc.

  公开号：US20190031664A1

  公开（公告）日：2019-01-31

  The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.

  本发明提供了化合物、其组合物以及使用这些化合物来抑制TYK2以及治疗TYK2介导的疾病的方法。
• TYK2 inhibitors and uses thereof
  申请人：Nimbus Lakshmi, Inc.

  公开号：US10562906B2

  公开（公告）日：2020-02-18

  The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.

  本发明提供了用于抑制 TYK2 和治疗 TYK2 介导的疾病的化合物、其组合物和使用方法。
• US20140256717A1
  申请人：——

  公开号：US20140256717A1

  公开（公告）日：2014-09-11
• MACROCYCLIC COMPOUNDS AS PROTEIN KINASE INHIBITORS
  申请人：Fundación Centro Nacional de Investigaciones Oncologicas Carlos III

  公开号：US20160296528A1

  公开（公告）日：2016-10-13

  There is provided compounds of formula I, wherein R1, R 2a , R 2b , R 2c , X, Y, Z, R 3 and ring A/B have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. PI3-K, particularly class I PI3K, PIM family kinase and/or mTOR) is desired and/or required, and particularly in the treatment of cancer. The invention also relates to combinations containing such compounds.
• US9808466B2
  申请人：——

  公开号：US9808466B2

  公开（公告）日：2017-11-07