N,N-diethyl-4-methylpyridine-3-carboxamide | 60511-48-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N,N-diethyl-4-methylpyridine-3-carboxamide
• 英文别名: N,N-Diethyl-4-methyl-nicotinamid；N,N-diethyl-4-methyl-nicotinamide
• CAS: 60511-48-0
• 化学式: C₁₁H₁₆N₂O
• 分子量: 192.261
• InChiKey: LKTUVGIRCQUYSV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  33.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N,N-diethyl-4-methylpyridine-3-carboxamide 、 (S)-3-Benzyloxy-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-butyraldehyde 在 仲丁基锂 作用下， 生成
  参考文献：
  名称：

  Design and synthesis of bisubstrate analogues for 3-hydroxy-3-methyl-glutaryl coenzyme a reductase

  摘要：

  The coupling of metalated pyridine derivatives with a chiral Weinreb amide derived from gluconolactone followed by stereoselective reduction of the resulting ketone are the key steps of the synthesis of bisubstrates analogues of the HMGCoA reduction by HMGR.

  DOI：

  10.1016/0960-894x(96)00077-7

文献信息

• Lateral Deprotometallation‐Trapping Reactions on Methylated Pyridines, Quinolines and Quinoxalines Using Lithium Diethylamide
  作者：Mohamed Hasyeoui、Peter M. Chapple、Frédéric Lassagne、Thierry Roisnel、Marie Cordier、Ali Samarat、Yann Sarazin、Florence Mongin

  DOI：10.1002/ejoc.202300555

  日期：2023.9.14

  The behavior of methylated heterocycles (picolines, 2,4-lutidine, methylquinolines and 2-methylquinoxaline) in deprotometallation-trapping sequences using lithium diethylamide was studied.

  研究了甲基化杂环（甲基吡啶、2,4-二甲基吡啶、甲基喹啉和 2-甲基喹喔啉）在使用二乙基氨基锂的去原金属化捕获序列中的行为。
• Design and synthesis of bisubstrate analogues for 3-hydroxy-3-methyl-glutaryl coenzyme a reductase
  作者：C Taillefumier、D de Fornel、Y Chapleur

  DOI：10.1016/0960-894x(96)00077-7

  日期：1996.3

  The coupling of metalated pyridine derivatives with a chiral Weinreb amide derived from gluconolactone followed by stereoselective reduction of the resulting ketone are the key steps of the synthesis of bisubstrates analogues of the HMGCoA reduction by HMGR.