1,3-Dimethyl-2-ethyl-pyrrolidin | 3199-23-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 1,3-Dimethyl-2-ethyl-pyrrolidin
• 英文别名: 2-ethyl-1,3-dimethyl-pyrrolidine；2-Aethyl-1,3-dimethyl-pyrrolidin；2-Ethyl-1,3-dimethylpyrrolidine
• CAS: 3199-23-3
• 化学式: C₈H₁₇N
• 分子量: 127.23
• InChiKey: GFGDQMHZPKLYCZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-ethylidene-1,3-dimethyl-pyrrolidine 在 甲酸 、 potassium formate 作用下， 生成 1,3-Dimethyl-2-ethyl-pyrrolidin
  参考文献：
  名称：

  Lukes; Dedek, Collection of Czechoslovak Chemical Communications, 1958, vol. 23, p. 2046,2049

  摘要：

  DOI：

文献信息

• STEROID ANALOGUES FOR NEUROPROTECTION
  申请人：Macnevin Christopher

  公开号：US20110263553A1

  公开（公告）日：2011-10-27

  Provided are steroid analogues functionalized with polar substituents at the C3 and/or C20 positions of the steroid ring system that exhibit improved water solubility. Also provided are pharmaceutical compositions comprising the steroid analogues and methods using the novel steroid analogues for the treatment and prevention of neurodegeneration in a patient following injury to the central nervous system.

  提供的是具有带极性取代基的类固醇类似物，这些取代基位于类固醇环系统的C3和/或C20位置，具有改善的水溶性。还提供了包含这些类固醇类似物的药物组合物，以及使用新型类固醇类似物治疗和预防中枢神经系统损伤后患者的神经退行性疾病的方法。
• Amino Compounds for Treatment of Complement Mediated Disorders
  申请人：Achillion Pharmaceuticals, Inc.

  公开号：US20150239894A1

  公开（公告）日：2015-08-27

  Compounds, methods of use, and processes for making inhibitors of complement factor D comprising Formula I, or a pharmaceutically acceptable salt or composition thereof, wherein R 12 or R 13 on the A group is an amino substituent (R 32 ) are provided. The inhibitors described herein target factor D and inhibit or regulate the complement cascade at an early and essential point in the alternative complement pathway, and reduce factor D's ability to modulate the classical and lectin complement pathways. The inhibitors of factor D described herein are capable of reducing the excessive activation of complement, which has been linked to certain autoimmune, inflammatory, and neurodegenerative diseases, as well as ischemia-reperfusion injury and cancer.

  本文提供了公式I或其药学上可接受的盐或组合物所组成的抑制补体因子D的化合物、使用方法和制备过程，其中A组上的R12或R13是氨基取代基（R32）。所述抑制剂靶向因子D并在替代性补体途径的早期和关键点上抑制或调节补体级联反应，并减少因子D调节经典和凝集素补体途径的能力。本文所述的因子D抑制剂能够减少过度激活补体，这与某些自身免疫性、炎症性和神经退行性疾病以及缺血再灌注损伤和癌症有关。
• Aryl, Heteroaryl, and Heterocyclic Compounds for Treatment of Complement Mediated Disorders
  申请人：Achillion Pharmaceuticals, Inc.

  公开号：US20150239895A1

  公开（公告）日：2015-08-27

  Compounds, methods of use, and processes for making inhibitors of complement factor D comprising Formula I, or a pharmaceutically acceptable salt or composition thereof wherein R 12 or R 13 on the A group is an aryl, heteroaryl or heterocycle (R 32 ) are provided. The inhibitors described herein target factor D and inhibit or regulate the complement cascade at an early and essential point in the alternative complement pathway, and reduce factor D's ability to modulate the classical and lectin complement pathways. The inhibitors of factor D described herein are capable of reducing the excessive activation of complement, which has been linked to certain autoimmune, inflammatory, and neurodegenerative diseases, as well as ischemia-reperfusion injury and cancer.

  本文提供了包含式I的补体因子D抑制剂的化合物、使用方法和制备过程，或其药学上可接受的盐或组合物，其中A组上的R12或R13是芳基、杂芳基或杂环（R32）。本文所描述的抑制剂针对因子D并在替代补体途径的早期和关键点上抑制或调节补体级联反应，并减少因子D调节经典和凝集素补体途径的能力。本文所描述的因子D抑制剂能够减少过度激活补体，这与某些自身免疫、炎症和神经退行性疾病、缺血再灌注损伤和癌症有关。
• Cyclic quaternary ammonium salts as fuel or lubricant additives
  申请人：INNOSPEC LIMITED

  公开号：US10689589B2

  公开（公告）日：2020-06-23

  Quaternary ammonium salts of formula: wherein each of R1 and R2 is independently selected from an optionally substituted alkyl, alkenyl or aryl group having less than 8 carbon atoms, R together with N forms an aliphatic or aromatic heterocycle having less than 12 carbons atoms and R5 is hydrogen or an optionally substituted hydrocarbyl group. The use of these compounds as fuel or lubricant additives, especially as diesel fuel additives.

  式中 R1 和 R2 各自独立地选自具有小于 8 个碳原子的任选取代的烷基、烯基或芳基，R 与 N 一起形成具有小于 12 个碳原子的脂肪族或芳香族杂环，R5 为氢或任选取代的烃基。这些化合物可用作燃料或润滑油添加剂，尤其是柴油添加剂。
• CYCLIC QUATERNARY AMMONIUM SALTS AS FUEL OR LUBRICANT ADDITIVES
  申请人：Innospec Limited

  公开号：EP3297988A1

  公开（公告）日：2018-03-28