acerogenin D

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: acerogenin D
• 英文别名: 4,10-Dihydroxy-2-oxatricyclo[13.2.2.13,7]icosa-1(17),3,5,7(20),15,18-hexaen-12-one
• 化学式: C₁₉H₂₀O₄
• 分子量: 312.365
• InChiKey: QRHDZGXGCHINRP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  23
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  aceroside V 以 乙醇 、 水 为溶剂， 反应 24.0h， 生成 acerogenin D
  参考文献：
  名称：

  Studies on the Constituents of Aceraceae Plants. XI. Two Types of Cyclic Diarylheptanoid from Acer nikoense.

  摘要：

  从Acer nikoense MAXIM（槭树科）的茎皮中分离出两种二芳基庚烷苷，即槭苷V（1）和槭苷XI（2）。水解后，1和2分别产生了新的二芳基庚烷苷，即槭苷D（6）和槭苷E（7）。槭苷D（6）与槭苷C（5）在化学上相关，而槭苷E与桤木酮（8）相关。根据化学和光谱学证据，1和2的化学结构分别确定为槭苷D的2-O-β-D-吡喃葡萄糖苷和槭苷E的3-O-β-D-吡喃葡萄糖苷。槭苷XI是从这种植物中分离出的第一个二苯基型二芳基庚烷苷。因此，A. nikoense含有三种类型的二芳基庚烷苷，即线型、环状二苯基和环状二苯醚。

  DOI：

  10.1248/cpb.41.1255

文献信息

• PHARMACEUTICAL COMPOSITION FOR PREVENTION AND/OR TREATMENT OF BONE DISEASE, FUNCTIONAL FOOD OR HEALTH FOOD COMPRISING THE COMPOSITION, AND PHARMACEUTICAL PREPARATION COMPRISING THE COMPOSITION AS ACTIVE INGREDIENT
  申请人：Akihisa, Toshihiro

  公开号：EP2050442A1

  公开（公告）日：2009-04-22

  The present invention provides a highly safe pharmaceutical composition for preventing and/or treating bone disease, a pharmaceutical preparation comprising thereof, a health food comprising thereof, a functional food comprising thereof. Since the present invention comprises the arylheptanoid compound shown in the following formula (I) and the derivatives thereof, it enables to prevent and/or treat the bone disease. (In the formula (I), R1 and R5 are a functional group selected from the group consisting of a hydrogen atom, alkyl group having carbon numbers 1 to 3, monosaccharide and disaccharide; R2, R3, and R4 are a functional group selected from the group consisting of a hydrogen atom, an oxygen atom, alkyl group having carbon numbers 1 to 3, monosaccharide and disaccharide; R5 may be bound on meta-position against heptylene group of another aryl group to form a ring.)

  本发明提供了一种用于预防和/或治疗骨病的高安全性药物组合物、由其组成的药物制剂、由其组成的保健食品、由其组成的功能性食品。由于本发明包含下式（I）所示的芳基庚烷类化合物及其衍生物，因此能够预防和/或治疗骨病。 (在式(I)中，R1和R5是选自氢原子、碳原子数为1至3的烷基、单糖和二糖的官能团；R2、R3和R4是选自氢原子、氧原子、碳原子数为1至3的烷基、单糖和二糖的官能团；R5可与另一芳基的庚基在元位置上结合形成环)。
• Pharmaceutical composition for prevention and/or treatment of bone disease, functional food or health food comprising the composition, and pharmaceutical preparation comprising the composition as active ingredient
  申请人：Akihisa, Toshihiro

  公开号：EP2407160A1

  公开（公告）日：2012-01-18

  The present invention provides a highly safe pharmaceutical composition for preventing and/or treating bone disease, a pharmaceutical preparation comprising thereof, a health food comprising thereof, a functional food comprising thereof. Since the present invention comprises the arylheptanoid compound shown in the following formula (I) and the derivatives thereof, it enables to prevent and/or treat the bone disease. (In the formula (I), R1 and R5 are a functional group selected from the group consisting of a hydrogen atom, alkyl group having carbon numbers 1 to 3, monosaccharide and disaccharide; R2, R3, and R4 are a functional group selected from the group consisting of a hydrogen atom, an oxygen atom, alkyl group having carbon numbers 1 to 3, monosaccharide and disaccharide; R5 may be bound on meta-position against heptylene group of another aryl group to form a ring.)

  本发明提供了一种用于预防和/或治疗骨病的高安全性药物组合物、由其组成的药物制剂、由其组成的保健食品、由其组成的功能性食品。由于本发明包含下式（I）所示的芳基庚烷类化合物及其衍生物，因此能够预防和/或治疗骨病。 (在式(I)中，R1和R5是选自氢原子、碳原子数为1至3的烷基、单糖和二糖的官能团；R2、R3和R4是选自氢原子、氧原子、碳原子数为1至3的烷基、单糖和二糖的官能团；R5可与另一芳基的庚基在元位置上结合形成环)。
• PHARMACEUTICAL COMPOSITION FOR PREVENTING AND/OR TREATING BONE DISEASE, FUNCTIONAL FOOD OR HEALTH FOOD AND PHARMACEUTICAL PREPARATION COMPRISING THEREOF AS ACTIVE INGREDIENT
  申请人：Woo Je-Tae

  公开号：US20090227527A1

  公开（公告）日：2009-09-10

  The present invention provides a highly safe pharmaceutical composition for preventing and/or treating bone disease, a pharmaceutical preparation comprising thereof, a health food comprising thereof, a functional food comprising thereof. Since the present invention comprises the arylheptanoid compound shown in the following formula (I) and the derivatives thereof, it enables to prevent and/or treat the bone disease. (In the formula (I), R 1 and R 5 are a functional group selected from the group consisting of a hydrogen atom, alkyl group having carbon numbers 1 to 3, monosaccharide and disaccharide; R 2 , R 3 , and R 4 are a functional group selected from the group consisting of a hydrogen atom, an oxygen atom, alkyl group having carbon numbers 1 to 3, monosaccharide and disaccharide; R 5 may be bound on meta-position against heptylene group of another aryl group to form a ring.)
• US8822705B2
  申请人：——

  公开号：US8822705B2

  公开（公告）日：2014-09-02
• Studies on the Constituents of Aceraceae Plants. XI. Two Types of Cyclic Diarylheptanoid from Acer nikoense.
  作者：Seiji NAGUMO、Norihiro KAJI、Takao INOUE、Masahiro NAGAI

  DOI：10.1248/cpb.41.1255

  日期：——

  Two diarylheptanoid glycosides, acerosides V (1) and XI (2), were isolated from the stem bark of Acer nikoense MAXIM. (Aceraceae). On hydrolysis, 1 and 2 yielded new diarylheptanoids, acerogenin D (6) and acerogenin E (7), respectively. Acerogenin D (6) was chemically correlated with acerogenin C (5), and acerogenin E, with alnusone (8). On the basis of the chemical and spectroscopic evidence, the chemical structures of 1 and 2 were established as the 2-O-β-D-glucopyranoside of acerogenin D and 3-O-β-D-glucopyranoside of acerogenin E, respectively. Aceroside XI is the first example of the biphenyl type of diarylheptanoid isolated from this plant. A. nikoense thus contains three types of diarylheptanoid, linear, cyclic biphenyl and cyclic diphenyl ether types.

  从Acer nikoense MAXIM（槭树科）的茎皮中分离出两种二芳基庚烷苷，即槭苷V（1）和槭苷XI（2）。水解后，1和2分别产生了新的二芳基庚烷苷，即槭苷D（6）和槭苷E（7）。槭苷D（6）与槭苷C（5）在化学上相关，而槭苷E与桤木酮（8）相关。根据化学和光谱学证据，1和2的化学结构分别确定为槭苷D的2-O-β-D-吡喃葡萄糖苷和槭苷E的3-O-β-D-吡喃葡萄糖苷。槭苷XI是从这种植物中分离出的第一个二苯基型二芳基庚烷苷。因此，A. nikoense含有三种类型的二芳基庚烷苷，即线型、环状二苯基和环状二苯醚。