rac-7-amino-1,3-dimethyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine | 919099-25-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 英文名称: rac-7-amino-1,3-dimethyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine
• 英文别名: 1,3-dimethyl-7-amino-2,3,4,5-tetrahydro-1H-benzo[d]azepine；3,5-dimethyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-8-ylamine；3,5-dimethyl-1,2,4,5-tetrahydro-3-benzazepin-8-amine
• CAS: 919099-25-5
• 化学式: C₁₂H₁₈N₂
• 分子量: 190.288
• InChiKey: IYMJEGHMXFXJRC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  29.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  、 1,3-dimethyl-7-nitro-2,3,4,5-tetrahydro-1H-benzo[d]azepine 、 1,3-dimethyl-8-nitro-2,3,4,5-tetrahydro-1H-benzo[d]azepine 在 钯 氢气 、 silica gel 、 二氯甲烷 、 乙醇 、 氨 作用下， 以 甲醇 为溶剂， 反应 5.5h， 以0.45 g of 1,3-dimethyl-7-amino-2,3,4,5-tetrahydro-1H-benzo[d]azepine are obtained的产率得到rac-7-amino-1,3-dimethyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine
  参考文献：
  名称：

  Substituted prolinamides, the preparation thereof and the use thereof as pharmaceutical compositions

  摘要：

  本发明提供了新的通式（I）中所定义的新的取代脯氨酰胺，其中D、L、E、G、J、M、R3、R4、R5和R13如权利要求1所定义，它们的互变异构体、对映异构体、二对映异构体、混合物和它们的盐，特别是与有机或无机酸或碱的生理耐受性盐，具有有价值的性质。

  公开号：

  US08003639B2

文献信息

• SUBSTITUTED GLYCINAMIDES, PROCESS FOR THEIR MANUFACTURE AND USE THEREOF AS MEDICAMENTS
  申请人：Priepke Henning

  公开号：US20100216769A1

  公开（公告）日：2010-08-26

  The present invention relates to new substituted glycinamides of general formula (I) wherein D, M, R 3 , R 4 and R 5 are defined as in the specification, the tautomers, enantiomers, diastereomers, mixtures and salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties.

  本发明涉及一般式(I)的新取代甘氨酰胺，其中D、M、R3、R4和R5如规范中定义，其互变异构体、对映异构体、非对映异构体、混合物以及其盐，特别是其与无机或有机酸或碱形成的生理上可接受的盐，具有有价值的特性。
• SUBSTITUTED PROLINAMIDES, THE PREPARATION THEREOF AND THE USE THEREOF AS PHARMACEUTICAL COMPOSITIONS
  申请人：Priepke Henning

  公开号：US20090048231A1

  公开（公告）日：2009-02-19

  The present invention provides new substituted prolinamides of the general formula (I) in which D, L, E, G, J, M, R 3 , R 4 , R 5 , and R 13 are defined as in claim 1 , their tautomers, their enantiomers, their diastereomers, their mixtures and their salts, more particularly their physiologically tolerated salts with organic or inorganic acids or bases, which exhibit valuable properties.

  本发明提供了一般式（I）的新置换脯氨酰胺，其中D、L、E、G、J、M、R3、R4、R5和R13如权利要求书中所定义，它们的互变异构体、对映异构体、顺反异构体、混合物和盐，特别是它们与有机或无机酸或碱形成的生理耐受盐，具有有价值的性质。
• PROCESS FOR THE SYNTHESIS OF DERIVATIVES OF 3-AMINO-TETRAHYDROFURAN-3-CARBOXYLIC ACID AND USE THEREOF AS MEDICAMENTS
  申请人：HAN Zhengxu

  公开号：US20130005962A1

  公开（公告）日：2013-01-03

  The present invention relates to a process for the manufacturing of substituted 3-amino-tetrahydrofuran-3-carboxylic acid amides of general formula (I) and their precursors in high optical purity to the precursors of the synthesis of substituted S-Amino-tetrahydrofuran-5-carboxylic acid amides of general formula (I) in high optical purity, and to the tautomers, enantiomers, diastereomers, mixtures and salts of substituted 3-amino-tetrahydrofuran-3-carboxylic acid amides of general formula (I) in high optical purity, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties.

  本发明涉及一种制备通式（I）的取代3-氨基四氢呋喃-3-羧酸酰胺及其前体的过程，以高光学纯度合成取代S-氨基四氢呋喃-5-羧酸酰胺的前体，以及取代3-氨基四氢呋喃-3-羧酸酰胺的互变异构体、对映异构体、非对映异构体、混合物和高光学纯度的盐，特别是与无机或有机酸或碱形成的生理上可接受的盐，具有有价值的性质。
• NEW SUBSTITUTED GLYCINAMIDES, PROCESS FOR THEIR MANUFACTURE AND USE THEREOF AS MEDICAMENTS
  申请人：PRIEPKE Henning

  公开号：US20130184256A1

  公开（公告）日：2013-07-18

  The present invention relates to new substituted glycinamides of general formula (I) wherein D, M, R 3 , R 4 and R 5 are defined as in the specification, the tautomers, enantiomers, diastereomers, mixtures and salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties.

  本发明涉及一种新的取代的甘氨酰胺，其一般式为（I），其中D、M、R3、R4和R5如规范中所定义，其互变异构体、对映异构体、顺反异构体、混合物和盐，特别是与无机或有机酸或碱的生理上可接受的盐，具有有价值的性质。
• WO2008/80891
  申请人：——

  公开号：——

  公开（公告）日：——