(1E,3S,4S,5S,6S,7E)-6-methoxy-3,5-dimethyl-8-phenyl-1-tributylstannylocta-1,7-dien-4-ol | 1364726-03-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (1E,3S,4S,5S,6S,7E)-6-methoxy-3,5-dimethyl-8-phenyl-1-tributylstannylocta-1,7-dien-4-ol
• CAS: 1364726-03-3
• 化学式: C₂₉H₅₀O₂Sn
• 分子量: 549.425
• InChiKey: VSURAMAYGUMVHP-QQFMMKGPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.29
• 重原子数：
  32
• 可旋转键数：
  17
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.66
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (1E,3S,4S,5S,6S,7E)-6-methoxy-3,5-dimethyl-8-phenyl-1-tributylstannylocta-1,7-dien-4-ol 在 水 、 对甲苯磺酸 作用下， 以87%的产率得到
  参考文献：
  名称：

  Enantioselective Synthesis of (+)-Crocacin C. An Example of a Highly Challenging Mismatched Double Asymmetric δ-Stannylcrotylboration Reaction

  摘要：

  A concise, enantioselective synthesis of (+)-crocacin C is described, featuring a highly diastereoselective mismatched double asymmetric delta-stannylcrotylboration of the stereochemically demanding chiral aldehyde 9 with the bifunctional crotylborane reagent (S)-E-10. The total synthesis of (+)-crocacin C was accomplished in seven steps (longest linear sequence) starting from commercially available precursors.

  DOI：

  10.1021/ol300476f

文献信息

• Enantioselective Synthesis of (+)-Crocacin C. An Example of a Highly Challenging Mismatched Double Asymmetric δ-Stannylcrotylboration Reaction
  作者：Ming Chen、William R. Roush

  DOI：10.1021/ol300476f

  日期：2012.4.6

  A concise, enantioselective synthesis of (+)-crocacin C is described, featuring a highly diastereoselective mismatched double asymmetric delta-stannylcrotylboration of the stereochemically demanding chiral aldehyde 9 with the bifunctional crotylborane reagent (S)-E-10. The total synthesis of (+)-crocacin C was accomplished in seven steps (longest linear sequence) starting from commercially available precursors.