2,6-diisopropylphenyl methacrylate | 87186-76-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: 2,6-diisopropylphenyl methacrylate
• 英文别名: 2,6-Di(propan-2-yl)phenyl 2-methylprop-2-enoate；[2,6-di(propan-2-yl)phenyl] 2-methylprop-2-enoate
• CAS: 87186-76-3
• 化学式: C₁₆H₂₂O₂
• 分子量: 246.349
• InChiKey: GPYDBCMCQUTHPT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-溴-2-甲基丙酸乙酯 、 2,6-diisopropylphenyl methacrylate 在 copper(l) iodide 、 五甲基二乙烯三胺 作用下， 以 甲苯 为溶剂， 生成
  参考文献：
  名称：

  通过叔烷基自由基对两种不同烯烃的顺序加成合成复杂的季碳

  摘要：

  我们报告了由 Cu 催化剂控制的叔烷基自由基对两种不同烯烃的序列调节自由基加成，我们将其称为“原子转移自由基加成-取代”反应。α-溴代羰基化合物（例如叔烷基自由基源）与甲基丙烯酸酯和苯乙烯的反应以顺序调节的方式发生，得到相应的具有跳过季碳中心的三组分产物。我们的方法为如何在受调节的脂肪链合成过程中控制叔烷基自由基的反应性提供了新的见解。

  DOI：

  10.1021/acs.orglett.3c00812

文献信息

• Responsive microgel and methods related thereto
  申请人：——

  公开号：US20030152623A1

  公开（公告）日：2003-08-14

  A responsive microgel is provided which responds volumetrically and reversibly to a change in one or more aqueous conditions selected from the group consisting of (temperature, pH, and ionic conditions) comprised of an ionizable network of covalently cross-linked homopolymeric ionizable monomers wherein the ionizable network is covalently attached to an amphiphilic copolymer to form a plurality of ‘dangling chains’ and wherein the ‘dangling chains’ of amphiphilic copolymer form immobile micelle-like aggregates in aqueous solution. A responsive microgel is further provided that comprises at least one therapeutic entity and delivers a substantially linear and sustained release of the therapeutic entity under physiological conditions.

  本发明提供了一种响应型微凝胶，该微凝胶可对选自由温度、pH 值和离子条件组成的组中的一种或多种水性条件的变化作出体积上和可逆的响应、和离子条件）组成的共价交联均聚可离子化单体的可离子化网络，其中可离子化网络与两性共聚物共价连接，形成多条 "悬链"，两性共聚物的 "悬链 "在水溶液中形成不动的胶束状聚集体。还提供了一种响应性微凝胶，它包含至少一种治疗实体，并能在生理条件下提供治疗实体的线性和持续释放。
• RESPONSIVE MICROGEL AND METHODS RELATED THERETO
  申请人：SUPRATEK PHARMA, INC.

  公开号：EP1478403A1

  公开（公告）日：2004-11-24
• Substituted cyclodextrin derivatives and process for their preparation
  申请人：Arcarios B.V.

  公开号：EP2550299A2

  公开（公告）日：2013-01-30
• Substituted Cyclodextrin Derivatives Useful As Intermediates For Producing Biologically Active Materials
  申请人：Van Calenbergh Serge

  公开号：US20130046087A1

  公开（公告）日：2013-02-21

  The present invention relates to substituted cyclodextrin derivatives which are particularly useful intermediates for producing well-defined carboxyalkylated cyclodextrins in contrast with the poorly-defined mixtures available through prior art procedures. The present invention also relates to processes for their preparation in a limited number of steps. These well-defined carboxyalkylated cyclodextrins can be polysulfated according to procedures standard in the art and some of these polysulfates, and alkali salts thereof, have been found to exhibit biologically active properties especially for the treatment and/or prophylaxis of degenerative joint diseases (e.g. osteoarthritis) or heparin-induced thrombocytopenia, or for cartilage repair or connective tissue repair.
• US7204997B2
  申请人：——

  公开号：US7204997B2

  公开（公告）日：2007-04-17