(2-methylbenzyl)(2-(pyridin-3-yl)ethyl)amine | 1179650-31-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2-methylbenzyl)(2-(pyridin-3-yl)ethyl)amine
• 英文别名: (2-Methylbenzyl)-(2-pyridin-3-ylethyl)amine；N-[(2-methylphenyl)methyl]-2-pyridin-3-ylethanamine
• CAS: 1179650-31-7
• 化学式: C₁₅H₁₈N₂
• mdl: MFCD13205325
• 分子量: 226.321
• InChiKey: BXMVFFTXDGHURC-UHFFFAOYSA-N

物化性质

• 沸点：
  371.0±27.0 °C(Predicted)
• 密度：
  1.039±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.266
• 拓扑面积：
  24.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (2-methylbenzyl)(2-(pyridin-3-yl)ethyl)amine 、 6-(5-bromopentyloxy)-1-methyl-1H-quinolin-2-one 在 potassium carbonate 、 盐酸 作用下， 以 N,N-二甲基甲酰胺 、 乙酸乙酯 为溶剂， 反应 8.0h， 生成 1-methyl-6-(5-((2-methylbenzyl)(2-(pyridin-3-yl)ethyl)amino)pentyloxy)-1H-quinolin-2-one dihydrochloride
  参考文献：
  名称：

  [EN] NITROGEN-CONTAINING COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF ATRIAL FIBRILLATION
  [FR] COMPOSÉ CONTENANT DE L'AZOTE ET COMPOSITION PHARMACEUTIQUE

  摘要：

  公开号：

  WO2011021726A3

文献信息

• NITROGEN-CONTAINING COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF ATRIAL FIBRILLATION
  申请人：Oshima Kunio

  公开号：US20120225866A1

  公开（公告）日：2012-09-06

  The present invention provides a novel diazepine compound that blocks the I Kur current or the Kv1.5 channel potently and more selectively than other K + channels. The present invention relates to a diazepine compound represented by General Formula (1) or a salt thereof, wherein R 1 , R 2 , R 3 , and R 4 are each independently hydrogen, lower alkyl, cyclo lower alkyl or lower alkoxy lower alkyl; R 2 and R 3 may be linked to form lower alkylene; A 1 is lower alkylene optionally substituted with one or more substituents selected from the group consisting of hydroxyl and oxo; Y 1 and Y 2 are each independently —N═ or —CH═; and R 5 is group represented by wherein R 6 and R 7 are each independently hydrogen or organic group; R 6 and R 7 may be linked to form a ring together with the neighboring group —X A —N—X B —; X A and X B are each independently a bond, lower alkylene, etc.

  本发明提供了一种新型的二氮杂环化合物，它可以有效地阻断IKur电流或Kv1.5通道，并比其他K+通道更具选择性。本发明涉及一种由通式（1）表示的二氮杂环化合物或其盐，其中R1、R2、R3和R4各自独立地表示氢、低碳基、环状低碳基或低烷氧基低碳基；R2和R3可以连接形成低碳烷基；A1是低碳烷基，可选地取代一个或多个羟基和氧代基；Y1和Y2各自独立地表示—N═或—CH═；R5是由下式表示的基：其中R6和R7各自独立地表示氢或有机基团；R6和R7可以与相邻的基团—XA—N—XB—一起形成环；XA和XB各自独立地表示键、低碳烷基等。
• Nitrogen-containing compounds and pharmaceutical compositions thereof for the treatment of atrial fibrillation
  申请人：Matsumura Shuuji

  公开号：US08822453B2

  公开（公告）日：2014-09-02

  The present invention provides a novel diazepine compound that blocks the IKur current or the Kv1.5 channel potently and more selectively than other K+ channels. The present invention relates to a diazepine compound represented by General Formula (1) or a salt thereof, wherein R1, R2, R3, and R4 are each independently hydrogen, lower alkyl, cyclo lower alkyl or lower alkoxy lower alkyl; R2 and R3 may be linked to form lower alkylene; A1 is lower alkylene optionally substituted with one or more substituents selected from the group consisting of hydroxyl and oxo; Y1 and Y2 are each independently —N═ or —CH═; and R5 is group represented by wherein R6 and R7 are each independently hydrogen or organic group; R6 and R7 may be linked to form a ring together with the neighboring group —XA—N—XB—; XA and XB are each independently a bond, lower alkylene, etc.

  本发明提供了一种新型二氮杂烷化合物，可比其他K+通道更有效地和更选择性地阻断IKur电流或Kv1.5通道。本发明涉及一种由通式（1）表示的二氮杂烷化合物或其盐，其中R1、R2、R3和R4各自独立地为氢、低碳基、环低碳基或低烷氧基低碳基；R2和R3可以连接形成低碳烷基；A1是低碳烷基，可选地取代一个或多个取代基，所述取代基选择自羟基和氧代基；Y1和Y2各自独立地为—N═或—CH═；以及R5是由以下式子表示的基：其中R6和R7各自独立地为氢或有机基团；R6和R7可以与相邻的基团—XA—N—XB—一起形成环；XA和XB各自独立地为键、低碳烷基等。
• US20140343278A1
  申请人：——

  公开号：——

  公开（公告）日：——
• US20140343277A1
  申请人：——

  公开号：——

  公开（公告）日：——
• US8822453B2
  申请人：——

  公开号：US8822453B2

  公开（公告）日：2014-09-02