2'-hydroxy-4-methoxy-[1,1'-biphenyl]-2-carboxylic acid | 1261944-06-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2'-hydroxy-4-methoxy-[1,1'-biphenyl]-2-carboxylic acid
• 英文别名: 2-(2-Hydroxyphenyl)-5-methoxybenzoic acid
• CAS: 1261944-06-2
• 化学式: C₁₄H₁₂O₄
• 分子量: 244.247
• InChiKey: ZZMGOSTWEZGVHZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-甲氧基-[1,1-联苯]-2-羧酸 在 lithium hydroxide monohydrate 作用下， 以 四氢呋喃 、 甲醇 、 水 为溶剂， 反应 20.0h， 以78%的产率得到2'-hydroxy-4-methoxy-[1,1'-biphenyl]-2-carboxylic acid
  参考文献：
  名称：

  Cu-Catalyzed Mild C(sp²)–H Functionalization Assisted by Carboxylic Acids en Route to Hydroxylated Arenes

  摘要：

  A formal Cu-catalyzed C(sp(2))-H hydroxylation assisted by benzoic acids is described. The procedure is characterized by its mild reaction conditions and wide substrate scope utilizing simple and cheap Cu catalysts, thus becoming a user-friendly and operationally simple protocol for C(sp(2))-H hydroxylation.

  DOI：

  10.1021/ja4047894

文献信息

• TETRAHYDROQUINOLINE DERIVATIVES AS ANTITHROMBOTIC AGENTS
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：EP1425015A2

  公开（公告）日：2004-06-09
• EP1425015A4
  申请人：——

  公开号：EP1425015A4

  公开（公告）日：2004-12-15
• [EN] TETRAHYDROQUINOLINE DERIVATIVES AS ANTITHROMBOTIC AGENTS<br/>[FR] DERIVES DE TETRAHYDROQUINOLINE UTILISES COMME AGENTS ANTITHROMBOTIQUES
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2003015715A2

  公开（公告）日：2003-02-27

  This invention relates generally to tetracyclic tetrahydroquinoline compounds, and analogues thereof, and pharmaceutically acceptable salt forms thereof, which are selective inhibitors of serine protease enzymes, especially factor VIIa; pharmaceutical compositions containing the same; and methods of using the same as anticoagulant agents for modulation of the coagulation cascade.
• Cu-Catalyzed Mild C(sp²)–H Functionalization Assisted by Carboxylic Acids en Route to Hydroxylated Arenes
  作者：Joan Gallardo-Donaire、Ruben Martin

  DOI：10.1021/ja4047894

  日期：2013.6.26

  A formal Cu-catalyzed C(sp(2))-H hydroxylation assisted by benzoic acids is described. The procedure is characterized by its mild reaction conditions and wide substrate scope utilizing simple and cheap Cu catalysts, thus becoming a user-friendly and operationally simple protocol for C(sp(2))-H hydroxylation.