N-((S)-2,3-dihydroxy-propyl)-3-(2-fluoro-4-iodo-phenylamino)-isonicotinamide monohydrochloride | 1236361-78-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N-((S)-2,3-dihydroxy-propyl)-3-(2-fluoro-4-iodo-phenylamino)-isonicotinamide monohydrochloride
• 英文别名: N-[(2S)-2,3-dihydroxypropyl]-3-[(2-fluoro-4-iodophenyl)amino]isonicotinamide hydrochloride；N-[(2S)-2,3-dihydroxypropyl]-3-[(2-fluoro-4-iodophenyl)amino]pyridine-4-carboxamide hydrochloride；Pimasertib hydrochloride；N-[(2S)-2,3-dihydroxypropyl]-3-(2-fluoro-4-iodoanilino)pyridine-4-carboxamide;hydrochloride
• CAS: 1236361-78-6
• 化学式: C₁₅H₁₅FIN₃O₃*ClH
• 分子量: 467.666
• InChiKey: HIEXZUXKTABHCP-PPHPATTJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.07
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  94.5
• 氢给体数：
  5
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  N-((S)-2,3-dihydroxy-propyl)-3-(2-fluoro-4-iodo-phenylamino)-isonicotinamide monohydrochloride 在 sodium hydroxide 作用下， 以 水 为溶剂， 反应 0.17h， 生成 N-[(2S)-2,3-二羟基丙基]-3-[(2-氟-4-碘苯基)氨基]-4-吡啶甲酰胺
  参考文献：
  名称：

  WO2013/178320

  摘要：

  公开号：
• 作为产物：
  描述：

  N-[[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl]-3-(2-fluoro-4-iodoanilino)pyridine-4-carboxamide 在 盐酸 作用下， 以 甲醇 、 乙醚 为溶剂， 生成 N-((S)-2,3-dihydroxy-propyl)-3-(2-fluoro-4-iodo-phenylamino)-isonicotinamide monohydrochloride
  参考文献：
  名称：

  WO2013/178320

  摘要：

  公开号：

文献信息

• Composition for inducing differentiation of multipotent neural stem cells into dopaminergic neurons and method for inducing differentiation of multipotent neural stem cells into dopaminergic neurons by using the same
  申请人：INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY

  公开号：US10179132B2

  公开（公告）日：2019-01-15

  Disclosed is a composition for inducing the differentiation of neural stem cells into dopaminergic neurons. The composition includes the compound represented by Formula 1 (“AS703026”) as a MEK 1/2 inhibitor. Also disclosed is a method for inducing the differentiation of neural stem cells into dopaminergic neurons by using the composition. Dopaminergic neurons whose differentiation from neural stem cells is induced by the composition and method can be applied to cell replacement therapies and gene therapies for the treatment of neurodegenerative diseases, such as Parkinson's disease, or can be widely used as materials for the examination of drug effects or numerous studies in the development of new drugs.

  公开了一种用于诱导神经干细胞分化为多巴胺能神经元的组合物。该组合物包括作为 MEK 1/2 抑制剂的式 1 所代表的化合物（"AS703026"）。还公开了一种使用该组合物诱导神经干细胞分化为多巴胺能神经元的方法。由该组合物和方法诱导神经干细胞分化而成的多巴胺能神经元可应用于治疗神经退行性疾病（如帕金森病）的细胞替代疗法和基因疗法，也可广泛用作药物效应检查材料或新药开发的大量研究。
• COMPOSITION FOR INDUCING DIFFERENTIATION OF MULTIPOTENT NEURAL STEM CELLS INTO DOPAMINERGIC NEURONS AND METHOD FOR INDUCING DIFFERENTIATION OF MULTIPOTENT NEURAL STEM CELLS INTO DOPAMINERGIC NEURONS BY USING THE SAME
  申请人：INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY

  公开号：US20160346329A1

  公开（公告）日：2016-12-01

  Disclosed is a composition for inducing the differentiation of neural stem cells into dopaminergic neurons. The composition includes the compound represented by Formula 1 (“AS703026”) as a MEK 1/2 inhibitor. Also disclosed is a method for inducing the differentiation of neural stem cells into dopaminergic neurons by using the composition. Dopaminergic neurons whose differentiation from neural stem cells is induced by the composition and method can be applied to cell replacement therapies and gene therapies for the treatment of neurodegenerative diseases, such as Parkinson's disease, or can be widely used as materials for the examination of drug effects or numerous studies in the development of new drugs.
• WO2013/178320
  申请人：——

  公开号：——

  公开（公告）日：——