4-methyl-N-(2-(2',3',4',5'-tetrahydro-[1,1'-biphenyl]-2-yl)ethyl)benzenesulfonamide | 1393882-93-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-methyl-N-(2-(2',3',4',5'-tetrahydro-[1,1'-biphenyl]-2-yl)ethyl)benzenesulfonamide
• 英文别名: N-[2-[2-(cyclohexen-1-yl)phenyl]ethyl]-4-methylbenzenesulfonamide
• CAS: 1393882-93-3
• 化学式: C₂₁H₂₅NO₂S
• 分子量: 355.501
• InChiKey: LEKHIZCLQNSSGZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  54.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-methyl-N-(2-(2',3',4',5'-tetrahydro-[1,1'-biphenyl]-2-yl)ethyl)benzenesulfonamide 在 三氟甲磺酸 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 以83%的产率得到2-(4-Methylphenyl)sulfonylspiro[3,4-dihydroisoquinoline-1,1'-cyclohexane]
  参考文献：
  名称：

  An alternative strategy to the Pictet–Spengler method for tetrahydroisoquinoline synthesis: a feasibility study

  摘要：

  Acid-catalysed cyclisations of the 2-aminoethyl styrene derivatives 9 give good to excellent yields of the corresponding tetrahydroisoquinolines 7 by an intramolecular hydroamination reaction, which represents an alternative and potentially more flexible strategy to the classical Pictet-Spengler method for the syntheses of such heterocycles. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.06.091

文献信息

• NOVEL SULFONAMIDE DERIVATIVES HAVING SELECTIVE NOX INHIBITING ACTIVITY
  申请人：GLUCOX BIOTECH AB

  公开号：US20210171456A1

  公开（公告）日：2021-06-10

  A compound of formula (I) or a pharmaceutically acceptable salt thereof. The compound is useful in therapy, e.g. for the treatment of a condition or disorder associated with nicotinamide adenine dinucleotide phosphate oxidase 4 or 2 (Nox4 or Nox2) activity. A pharmaceutical composition comprising the compound.