2-amino-8-bromo-6-dimethylamino-9-isobutylpurine | 1609090-81-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 2-amino-8-bromo-6-dimethylamino-9-isobutylpurine
• 英文别名: 8-bromo-6-N,6-N-dimethyl-9-(2-methylpropyl)purine-2,6-diamine
• CAS: 1609090-81-4
• 化学式: C₁₁H₁₇BrN₆
• 分子量: 313.2
• InChiKey: JNXINIUTWPPVOD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  72.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-amino-6-chloro-9-(2-methyl-2-propenyl)purine 在 pyridinium hydrobromide perbromide 、 palladium 10% on activated carbon 、 氢气 作用下， 以 甲醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 7.0h， 生成 2-amino-8-bromo-6-dimethylamino-9-isobutylpurine
  参考文献：
  名称：

  8-Bromination of 2,6,9-trisubstituted purines with pyridinium tribromide

  摘要：

  2,6,9-Trisubstituted purines are brominated in high yields using pyridinium tribromide as the brominating reagent. This procedure works excellently for electron-rich purines having electron-donating substituents at the 2- and 6-positions. The use of pyridinium tribromide, a crystalline alternative to elemental bromine, improves the bromination procedure for this type of substrate as the reagent is easy to handle and the work-up and purification procedures are simplified. (C) 2014 The Authors. Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2014.03.084

文献信息

• 8-Bromination of 2,6,9-trisubstituted purines with pyridinium tribromide
  作者：David Bliman、Mariell Pettersson、Mattias Bood、Morten Grøtli

  DOI：10.1016/j.tetlet.2014.03.084

  日期：2014.4

  2,6,9-Trisubstituted purines are brominated in high yields using pyridinium tribromide as the brominating reagent. This procedure works excellently for electron-rich purines having electron-donating substituents at the 2- and 6-positions. The use of pyridinium tribromide, a crystalline alternative to elemental bromine, improves the bromination procedure for this type of substrate as the reagent is easy to handle and the work-up and purification procedures are simplified. (C) 2014 The Authors. Published by Elsevier Ltd.