2-Amino-4-butyl-6-phenylsulfanylpyridine-3,5-dicarbonitrile | 1202481-88-6

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 2-Amino-4-butyl-6-phenylsulfanylpyridine-3,5-dicarbonitrile
• 英文别名: 2-amino-4-butyl-6-phenylsulfanylpyridine-3,5-dicarbonitrile
• CAS: 1202481-88-6
• 化学式: C₁₇H₁₆N₄S
• 分子量: 308.407
• InChiKey: AONPAHBLOIEBIX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  112
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  正戊醛 在 copper(I) iodide 作用下， 以 乙醇 为溶剂， 反应 3.58h， 生成 2-Amino-4-butyl-6-phenylsulfanylpyridine-3,5-dicarbonitrile
  参考文献：
  名称：

  CuI nanoparticles: a highly active and easily recyclable catalyst for the synthesis of 2-amino-3,5-dicyano-6-sulfanyl pyridines

  摘要：

  CuI nanoparticles as a worthwhile and reusable catalyst supply an eco-friendly procedure for the synthesis of 2-amino-3,5-dicyano-6-sulfanyl pyridine derivatives. The products were obtained in high yields and short reaction times via multicomponent reaction of aldehydes, malononitrile and thiols under reflux conditions. The method presented is mild, efficient, inexpensive and satisfactory to give the products in the presence of novel nanoscale materials.

  DOI：

  10.1080/17415993.2012.728220

文献信息

• One-step, three-component synthesis of highly substituted pyridines using silica nanoparticle as reusable catalyst
  作者：Subhash Banerjee、Grigoriy Sereda

  DOI：10.1016/j.tetlet.2009.09.137

  日期：2009.12

  One-step synthesis of ‘privileged medicinal scaffolds’, 2-amino-3,5-dicarbonitrile- 6-sulfanylpyridines, has been demonstrated via a multicomponent reaction of aldehydes, malononitrile, and thiols using silica nanoparticle (NP) as catalysts. The silica NP catalysts are very mild (nearly neutral in nature), effective, environmentally benign, and retain most of their activities after being reused for

  通过使用二氧化硅纳米颗粒（NP）作为催化剂的醛，丙二腈和硫醇的多组分反应，已证明了“特权药物支架” 2-氨基-3,5-二甲腈-6-磺酰氨吡啶的一步合成。二氧化硅NP催化剂非常温和（本质上几乎是中性的），有效，对环境无害，并且在重复使用3次后仍保留了大部分活性。