N-carbamoyl-S-benzyl-S-(4-chlorophenyl)sulfoximine | 1204678-07-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-carbamoyl-S-benzyl-S-(4-chlorophenyl)sulfoximine
• 英文别名: [Benzyl-(4-chlorophenyl)-oxo-lambda6-sulfanylidene]urea；[benzyl-(4-chlorophenyl)-oxo-λ6-sulfanylidene]urea
• CAS: 1204678-07-8
• 化学式: C₁₄H₁₃ClN₂O₂S
• 分子量: 308.788
• InChiKey: SRRTVRJHWMOHAZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  80.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-carbamoyl-S-benzyl-S-(4-chlorophenyl)sulfoximine 在 甲醇 、 potassium carbonate 作用下， 以86%的产率得到S-benzyl-S-(4-chlorophenyl)-NH-sulfoximine
  参考文献：
  名称：

  Synthesis of aryl benzyl NH-sulfoximines

  摘要：

  Efficient synthesis and characterisation of a series of aryl benzyl NH-sulfoximines are described. While N-protected versions of aryl benzyl sulfoximines have been previously described, reports of their de-protection are very limited, presumably due to lability under the typically harsh deprotection conditions which can be employed with the less reactive aryl alkyl derivatives. Use of N-cyanosulfoximines as key intermediates overcomes these difficulties leading to an effective synthetic route to these compounds. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.10.056
• 作为产物：
  描述：

  N-cyano-S-benzyl-S-(4-chlorophenyl)sulfoximine 在 三氟乙酸 、 水 作用下， 以 二氯甲烷 为溶剂， 以56%的产率得到N-carbamoyl-S-benzyl-S-(4-chlorophenyl)sulfoximine
  参考文献：
  名称：

  Synthesis of aryl benzyl NH-sulfoximines

  摘要：

  Efficient synthesis and characterisation of a series of aryl benzyl NH-sulfoximines are described. While N-protected versions of aryl benzyl sulfoximines have been previously described, reports of their de-protection are very limited, presumably due to lability under the typically harsh deprotection conditions which can be employed with the less reactive aryl alkyl derivatives. Use of N-cyanosulfoximines as key intermediates overcomes these difficulties leading to an effective synthetic route to these compounds. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.10.056

文献信息

• Synthesis of aryl benzyl NH-sulfoximines
  作者：Nicola Barry、Nicolas Brondel、Simon E. Lawrence、Anita R. Maguire

  DOI：10.1016/j.tet.2009.10.056

  日期：2009.12

  Efficient synthesis and characterisation of a series of aryl benzyl NH-sulfoximines are described. While N-protected versions of aryl benzyl sulfoximines have been previously described, reports of their de-protection are very limited, presumably due to lability under the typically harsh deprotection conditions which can be employed with the less reactive aryl alkyl derivatives. Use of N-cyanosulfoximines as key intermediates overcomes these difficulties leading to an effective synthetic route to these compounds. (C) 2009 Elsevier Ltd. All rights reserved.