7-Methyl-5,6,8,9-tetrahydrobenzo[7]annulene-3,7-diol | 1138003-72-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 7-Methyl-5,6,8,9-tetrahydrobenzo[7]annulene-3,7-diol
• 英文别名: 7-methyl-5,6,8,9-tetrahydrobenzo[7]annulene-3,7-diol
• CAS: 1138003-72-1
• 化学式: C₁₂H₁₆O₂
• 分子量: 192.258
• InChiKey: VEWDSZCDQUHDOO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  7-Methyl-5,6,8,9-tetrahydrobenzo[7]annulene-3,7-diol 在 potassium carbonate 、 [双(三氟乙酰氧基)碘]苯 作用下， 以 乙腈 为溶剂， 以30%的产率得到(1R,9S)-9,11-dimethyl-10-oxa-12-azatricyclo[7.3.2.01,6]tetradeca-2,5,11-trien-4-one
  参考文献：
  名称：

  An Oxidative Dearomatization Cyclization Model for Cortistatin A

  摘要：

  The feasibility of a hypervalent iodine-mediated oxidative dearomatization/cyclization to produce the oxabicyclo[3.2.1]octene of cortistatin A has been demonstrated through a model study. An interesting tandem cyclization via a Ritter intermediate has been observed when a slightly different substrate was used.

  DOI：

  10.3987/com-08-s(f)6
• 作为产物：
  描述：

  7-Methyl-8,9-dihydrobenzo[7]annulene-3,7-diol 在 palladium on activated charcoal 、 氢气 作用下， 以 甲醇 为溶剂， 以97%的产率得到7-Methyl-5,6,8,9-tetrahydrobenzo[7]annulene-3,7-diol
  参考文献：
  名称：

  An Oxidative Dearomatization Cyclization Model for Cortistatin A

  摘要：

  The feasibility of a hypervalent iodine-mediated oxidative dearomatization/cyclization to produce the oxabicyclo[3.2.1]octene of cortistatin A has been demonstrated through a model study. An interesting tandem cyclization via a Ritter intermediate has been observed when a slightly different substrate was used.

  DOI：

  10.3987/com-08-s(f)6

文献信息

• An Oxidative Dearomatization Cyclization Model for Cortistatin A
  作者：Samuel J. Danishefsky、Mingji Dai

  DOI：10.3987/com-08-s(f)6

  日期：——

  The feasibility of a hypervalent iodine-mediated oxidative dearomatization/cyclization to produce the oxabicyclo[3.2.1]octene of cortistatin A has been demonstrated through a model study. An interesting tandem cyclization via a Ritter intermediate has been observed when a slightly different substrate was used.