1,3-Bis[3,5-bis[2,6-di(propan-2-yl)phenyl]phenyl]-2-nitrososelanylbenzene | 796055-71-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,3-Bis[3,5-bis[2,6-di(propan-2-yl)phenyl]phenyl]-2-nitrososelanylbenzene
• 英文别名: 1,3-bis[3,5-bis[2,6-di(propan-2-yl)phenyl]phenyl]-2-nitrososelanylbenzene
• CAS: 796055-71-5
• 化学式: C₆₆H₇₇NOSe
• 分子量: 979.303
• InChiKey: XJDFPBGQBKXBTP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  19.69
• 重原子数：
  69
• 可旋转键数：
  15
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  29.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,3-Bis[3,5-bis[2,6-di(propan-2-yl)phenyl]phenyl]-2-nitrososelanylbenzene 以 氘代苯 为溶剂， 反应 13.0h， 以100%的产率得到1-[2-[[2,6-Bis[3,5-bis[2,6-di(propan-2-yl)phenyl]phenyl]phenyl]diselanyl]-3-[3,5-bis[2,6-di(propan-2-yl)phenyl]phenyl]phenyl]-3,5-bis[2,6-di(propan-2-yl)phenyl]benzene
  参考文献：
  名称：

  稳定硒亚硝基硒醇的热解和光解

  摘要：

  Se-亚硝基硒醇的热反应性和光反应性已通过使用受碗型取代基保护的稳定化合物来阐明。Se-亚硝基硒醇 1 的热解提供了...

  DOI：

  10.1246/cl.2005.654
• 作为产物：
  描述：

  5',5'''-bis(2,6-diisopropylphenyl)-2,6,2'''',6''''-tetraisopropyl-m-quinquephenyl-2''-yl-SeH 在 亚硝酸乙酯 作用下， 以 氘代氯仿 为溶剂， 反应 2.0h， 以88.9%的产率得到1,3-Bis[3,5-bis[2,6-di(propan-2-yl)phenyl]phenyl]-2-nitrososelanylbenzene
  参考文献：
  名称：

  Isolation of a Se-Nitrososelenol:  A New Class of Reactive Nitrogen Species Relevant to Protein Se-Nitrosation

  摘要：

  Nitric oxide (NO) is a messenger molecule implicated in a number of physiological processes. Nitrosation of selenoproteins has been suggested as playing an important role in NO-mediated cellular functions such as the inactivation of glutathione peroxidase (GPx), but no chemical information about Se-nitrosated species has been available to date. Here a stable Se-nitrososelenol (RSeNO), a new class of NO derivative, was synthesized and fully characterized by X-ray crystallography and spectroscopic methods. This Se-nitrososelenol can be formed by direct transnitrosation from an S-nitrosothiol to a selenol, as is the case in the proposed mechanism for the NO-mediated inactivation of GPx.

  DOI：

  10.1021/ja0457009

文献信息

• Isolation of a <i>Se-</i>Nitrososelenol:  A New Class of Reactive Nitrogen Species Relevant to Protein <i>Se-</i>Nitrosation
  作者：Keiichi Shimada、Kei Goto、Takayuki Kawashima、Nozomi Takagi、Yoong-Kee Choe、Shigeru Nagase

  DOI：10.1021/ja0457009

  日期：2004.10.1

  Nitric oxide (NO) is a messenger molecule implicated in a number of physiological processes. Nitrosation of selenoproteins has been suggested as playing an important role in NO-mediated cellular functions such as the inactivation of glutathione peroxidase (GPx), but no chemical information about Se-nitrosated species has been available to date. Here a stable Se-nitrososelenol (RSeNO), a new class of NO derivative, was synthesized and fully characterized by X-ray crystallography and spectroscopic methods. This Se-nitrososelenol can be formed by direct transnitrosation from an S-nitrosothiol to a selenol, as is the case in the proposed mechanism for the NO-mediated inactivation of GPx.
• Thermolysis and Photolysis of Stable<i>Se</i>-Nitrososelenols
  作者：Keiichi Shimada、Kei Goto、Takayuki Kawashima

  DOI：10.1246/cl.2005.654

  日期：2005.5

  The thermal reactivity and photoreactivity of Se-nitrososelenols have been elucidated by using stable compounds protected by bowl-type substituents. Thermolysis of Se-nitrososelenol 1 afforded dise...

  Se-亚硝基硒醇的热反应性和光反应性已通过使用受碗型取代基保护的稳定化合物来阐明。Se-亚硝基硒醇 1 的热解提供了...