6,6-二氟双环[3.1.0]己-3-胺盐酸盐 | 1955524-13-6

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机氟化物
• 中文名称: 6,6-二氟双环[3.1.0]己-3-胺盐酸盐
• 英文名称: 6,6-difluorobicyclo[3.1.0]hexan-3-amine hydrochloride
• 英文别名: 6,6-difluorobicyclo[3.1.0]hexan-3-amine;hydrochloride
• CAS: 1955524-13-6
• 化学式: C₆H₉F₂N*ClH
• 分子量: 169.602
• InChiKey: DDXVVYHUUNFLFN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.41
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  26
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  7-溴-3,4-二氢异喹啉-2(1H)-羧酸叔丁酯 、 6,6-二氟双环[3.1.0]己-3-胺盐酸盐 在 XPhos Pd G2 、 sodium t-butanolate 作用下， 以 甲苯 为溶剂， 以29 %的产率得到tert-butyl 7-((6,6-difluorobicyclo[3.1.0]hexan-3-yl)amino)-3,4-dihydroisoquinoline-2(1H)-carboxylate
  参考文献：
  名称：

  WO2022/240966

  摘要：

  公开号：
• 作为产物：
  描述：

  6,6-二氟双环[3.1.0]己烷-3-羧酸 在 叠氮磷酸二苯酯 、 三乙胺 、 盐酸 作用下， 以 叔丁醇 、 1,4-二氧六环 、 水 为溶剂， 以12.7 g的产率得到6,6-二氟双环[3.1.0]己-3-胺盐酸盐
  参考文献：
  名称：

  官能化的二氟环丙烷的合成：药物发现的独特组成部分

  摘要：

  由功能化烯烃和TMSCF 3 / NaI合成了用于药物发现的含二氟环丙烷的结构单元。获得了新颖的氟化酸，胺，氨基酸，醇，酮和磺酰氯。

  DOI：

  10.1002/chem.201705708

文献信息

• Cyano cyclobutyl compounds for CBL-B inhibition and uses thereof
  申请人：Nurix Therapeutics, Inc.

  公开号：US11530229B2

  公开（公告）日：2022-12-20

  Compounds, compositions, and methods for use in inhibiting the E3 enzyme Cbl-b in the ubiquitin proteasome pathway are disclosed. The compounds, compositions, and methods can be used to modulate the immune system, to treat diseases amenable to immune system modulation, and for treatment of cells in vivo, in vitro, or ex vivo. Also disclosed are pharmaceutical compositions comprising a Cbl-b inhibitor and a cancer vaccine, as well as methods for treating cancer using a Cbl-b inhibitor and a cancer vaccine; and pharmaceutical compositions comprising a Cbl-b inhibitor and an oncolytic virus, as well as methods for treating cancer using a Cbl-b inhibitor and an oncolytic virus.

  本发明公开了用于抑制泛素蛋白酶体途径中的 E3 酶 Cbl-b 的化合物、组合物和方法。这些化合物、组合物和方法可用于调节免疫系统，治疗免疫系统可调节的疾病，以及体内、体外或体外细胞的治疗。还公开了包含 Cbl-b 抑制剂和癌症疫苗的药物组合物，以及使用 Cbl-b 抑制剂和癌症疫苗治疗癌症的方法；以及包含 Cbl-b 抑制剂和溶瘤病毒的药物组合物，以及使用 Cbl-b 抑制剂和溶瘤病毒治疗癌症的方法。
• CYANO CYCLOBUTYL COMPOUNDS FOR CBL-B INHIBITION AND USES THEREOF
  申请人：Nurix Therapeutics, Inc.

  公开号：US20210053986A1

  公开（公告）日：2021-02-25

  Compounds, compositions, and methods for use in inhibiting the E3 enzyme Cbl-b in the ubiquitin proteasome pathway are disclosed. The compounds, compositions, and methods can be used to modulate the immune system, to treat diseases amenable to immune system modulation, and for treatment of cells in vivo, in vitro, or ex vivo. Also disclosed are pharmaceutical compositions comprising a Cbl-b inhibitor and a cancer vaccine, as well as methods for treating cancer using a Cbl-b inhibitor and a cancer vaccine; and pharmaceutical compositions comprising a Cbl-b inhibitor and an oncolytic virus, as well as methods for treating cancer using a Cbl-b inhibitor and an oncolytic virus.
• [EN] CYANO CYCLOBUTYL COMPOUNDS FOR CBL-B INHIBITION AND USES THEREOF<br/>[FR] COMPOSÉS CYANO-CYCLOBUTYLE POUR L'INHIBITION DE CBL-B ET LEURS UTILISATIONS
  申请人：NURIX THERAPEUTICS INC

  公开号：WO2020236654A1

  公开（公告）日：2020-11-26

  Compounds, compositions, and methods for use in inhibiting the E3 enzyme Cbl-b in the ubiquitin proteasome pathway are disclosed. The compounds, compositions, and methods can be used to modulate the immune system, to treat diseases amenable to immune system modulation, and for treatment of cells in vivo, in vitro, or ex vivo. Also disclosed are pharmaceutical compositions comprising a Cbl-b inhibitor and a cancer vaccine, as well as methods for treating cancer using a Cbl-b inhibitor and a cancer vaccine; and pharmaceutical compositions comprising a Cbl-b inhibitor and an oncolytic virus, as well as methods for treating cancer using a Cbl-b inhibitor and an oncolytic virus.