(-)-(2R)-2-(3-chlorophenyl)-6-methyl-1,2-dihydropyridin-4-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (-)-(2R)-2-(3-chlorophenyl)-6-methyl-1,2-dihydropyridin-4-one
• 英文别名: (2R)-2-(3-chlorophenyl)-6-methyl-2,3-dihydro-1H-pyridin-4-one
• 化学式: C₁₂H₁₂ClNO
• 分子量: 221.686
• InChiKey: HQKMTBWPZJUWCS-GFCCVEGCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (Z)-(R)-6-Amino-6-(3-chloro-phenyl)-4-hydroxy-hex-3-en-2-one; hydrochloride 在 ammonium hydroxide 作用下， 以 二氯甲烷 为溶剂， 生成 (-)-(2R)-2-(3-chlorophenyl)-6-methyl-1,2-dihydropyridin-4-one
  参考文献：
  名称：

  Efficient synthesis of 2-aryl-6-methyl-2,3-dihydro-1H-pyridin-4-ones

  摘要：

  Syntheses of 2-aryl-6-methyl-2,3-dihydra-1H-pyridin-4-ones were achieved starting from corresponding beta-aryl-amino acids. This reaction sequence involved, as a key step, the condensation of an acid chloride with a diketone using SmI3 as catalyst. A final intramolecular cyclization furnished the attempted product. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)02164-4

文献信息

• 1-aza-2-alkyl-6-aryl-cycloalkanes
  申请人：——

  公开号：US20020042413A1

  公开（公告）日：2002-04-11

  Compound of formula (I): 1 wherein: n represents 0 or 1, R 1 represents hydrogen, arylalkyl, alkyl, acyl, alkoxycarbonyl, arylalkoxycarbonyl or trifluoroacetyl, R 2 represents alkyl, X represents oxygen, chlorine, OR 3 , SR 4 or NOR 5 , R 3 represents hydrogen, alkyl, acyl, alkoxycarbonyl or arylalkoxycarbonyl, R 4 represents hydrogen, alkyl or aryl, R 5 represents hydrogen or optionally substituted alkyl, ═ represents a single or double bond, Ar represents aryl or heteroaryl, its isomers and addition salts thereof with a pharmaceutically acceptable acid, and medicinal products containing the same which are useful as facilitators of memory and cognition and antalgic agents.

  化合物的结构式(I):1其中： n代表0或1， R1代表氢、芳基烷基、烷基、酰基、烷氧羰基、芳基烷氧羰基或三氟乙酰基， R2代表烷基， X代表氧、氯、OR3、SR4或NOR5， R3代表氢、烷基、酰基、烷氧羰基或芳基烷氧羰基， R4代表氢、烷基或芳基， R5代表氢或可选择取代的烷基， ═代表单键或双键， Ar代表芳基或杂环芳基， 它的异构体和药用可接受酸的加合物，以及含有它们的药物制品，可用作记忆和认知促进剂和止痛剂。
• 1-Aza-2-Alkyl-6-Aryl-Cycloalcanes utiles pour améliorer la mémoire
  申请人：LES LABORATOIRES SERVIER

  公开号：EP1050530B1

  公开（公告）日：2003-10-22
• US6323222B1
  申请人：——

  公开号：US6323222B1

  公开（公告）日：2001-11-27
• US6451789B1
  申请人：——

  公开号：US6451789B1

  公开（公告）日：2002-09-17
• Efficient synthesis of 2-aryl-6-methyl-2,3-dihydro-1H-pyridin-4-ones
  作者：Olivier Renault、Jean Guillon、Patrick Dallemagne、Sylvain Rault

  DOI：10.1016/s0040-4039(99)02164-4

  日期：2000.1

  Syntheses of 2-aryl-6-methyl-2,3-dihydra-1H-pyridin-4-ones were achieved starting from corresponding beta-aryl-amino acids. This reaction sequence involved, as a key step, the condensation of an acid chloride with a diketone using SmI3 as catalyst. A final intramolecular cyclization furnished the attempted product. (C) 2000 Elsevier Science Ltd. All rights reserved.