N-(2-acetylphenyl)-3-fluorobenzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(2-acetylphenyl)-3-fluorobenzamide
• 化学式: C₁₅H₁₂FNO₂
• mdl: MFCD07669151
• 分子量: 257.264
• InChiKey: TXVBYWXCWQHROV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.066
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-(2-acetylphenyl)-3-fluorobenzamide 在 potassium tert-butylate 作用下， 生成 2-(3-fluorophenyl)quinolin-4(1H)-one
  参考文献：
  名称：

  Ruthenium(II) Catalyzed Regiospecific C–H/O–H Annulations of Directing Arenes via Weak Coordination

  摘要：

  Ruthenium(II) catalyzed oxidative CH/OH annulations have been demonstrated using two different directing arenes viz. 2-arylquinolinone and 2-arylbenzoxazinone with internal alkynes. Regiospecific annulations have been observed for both directing arenes via the assistance of weaker carbonyl oxygen in the presence of a stronger nitrogen-directing site. In this substrate-controlled convergent protocol the weaker directing group dictates the annulation path.

  DOI：

  10.1021/acs.orglett.5b02967

文献信息

• Ruthenium(II) Catalyzed Regiospecific C–H/O–H Annulations of Directing Arenes via Weak Coordination
  作者：Arghya Banerjee、Sourav Kumar Santra、Prakash Ranjan Mohanta、Bhisma K. Patel

  DOI：10.1021/acs.orglett.5b02967

  日期：2015.11.20

  Ruthenium(II) catalyzed oxidative CH/OH annulations have been demonstrated using two different directing arenes viz. 2-arylquinolinone and 2-arylbenzoxazinone with internal alkynes. Regiospecific annulations have been observed for both directing arenes via the assistance of weaker carbonyl oxygen in the presence of a stronger nitrogen-directing site. In this substrate-controlled convergent protocol the weaker directing group dictates the annulation path.