agasyllin | 1186136-02-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: agasyllin
• 英文别名: decursinol angelate；(2,2-dimethyl-8-oxo-3,4-dihydropyrano[3,2-g]chromen-3-yl) (Z)-2-methylbut-2-enoate
• CAS: 1186136-02-6
• 化学式: C₁₉H₂₀O₅
• 分子量: 328.365
• InChiKey: AGABNGOXUSXQDD-WZUFQYTHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  61.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  agasyllin 在 氢氧化钾 作用下， 生成 decursinol
  参考文献：
  名称：

  Anti-Helicobacter pylori Activity of Herbal Medicines.

  摘要：

  The extracts of Coptidis japonica (rhizoma), Eugenia caryophyllata (flower), Rheum palmatum (rhizoma), Magnolia officinalis (cortex) and Rhus javanica (galla rhois) potently inhibited the grow of Helicobacter pylori (HP). However, these herbal extracts showed no inhibitory effect on HP urease except Galla rhois. Among the components separated from active herbal extracts by silica gel column chromatography, the inhibitory effects of decursinal angelate and decursion on the growth of HP were the most potent, followed by magnolol, berberine, cinnamic acid, decursinol and gallic acid. Minimum inhibitory concentrations (MICs) of decursin and decursinol anglate were 6-20 μg/ml

  DOI：

  10.1248/bpb.21.990

文献信息

• [EN] COMPOSITION COMPRISING DECURSIN DERIVATIVE FOR TREATING AND PREVENTING ATOPIC DERMATITIS<br/>[FR] COMPOSITION RENFERMANT UN DÉRIVÉ DE LA DÉCURSINE POUR TRAITER ET PRÉVENIR LA DERMATITE ATOPIQUE
  申请人：PARK YONG JIN

  公开号：WO2008102994A1

  公开（公告）日：2008-08-28

  [EN] The present invention relates to the novel decursin derivatives, the preparation thereof and the composition comprising the same. The novel decursin derivatives of the present invention showedpotent inhibiting activity of the release of MCP-1, IL-6 and IL-8 induced by dermite in THP-1 or EoL-1 cell, therefore the compounds can be useful in treating or preventing atopic dermatitis.
  [FR] L'invention concerne de nouveaux dérivés de la décursine, un procédé de préparation de ceux-ci et une composition comprenant un tel composé. Ces nouveaux dérivés de la décursine présentent une puissante activité d'inhibition de la libération de MCP-1, de l'IL-6 et de l'IL-8 induite par une dermite dans une cellule THP-1 ou EoL-1, ces composés pouvant donc être utiles pour traiter ou prévenir la dermatite.
• [EN] NOVEL COUMARIN-BASED COMPOUNDS, PREPARATION METHOD THEREOF, AND MULTIDRUG RESISTANCE INHIBITORY PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AS ACTIVE INGREDIENTS<br/>[FR] NOUVEAUX COMPOSÉS À BASE DE COUMARINE, PROCÉDÉ DE PRÉPARATION DE CES DERNIERS ET COMPOSITIONS PHARMACEUTIQUES INHIBANT LA RÉSISTANCE PLÉIOTROPE CONTENANT CES NOUVEAUX COMPOSÉS EN TANT QU'INGRÉDIENTS ACTIFS
  申请人：KOREA RES INST OF BIOSCIENCE

  公开号：WO2010064817A2

  公开（公告）日：2010-06-10

  본 발명은 신규 쿠마린계 화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 다약제내성 억제용 약학적 조성물에 관한 것으로, 본 발명에 따른 쿠마린계 화합물은 다약제내성의 주요 원인인 P-당단백질(P-glycoprotein, Pgp)의 과발현에 대한 억제활성 및 항암제와의 병용투여시 항암활성의 증가를 나타내어 항암제에 대한 다약제내성 극복제제, 치료제 또는 조절제로 이용될 수 있으며, 항암제의 효과를 증진시켜 암환자의 생존률을 높일 수 있고, 병용투여하는 항암제의 용량을 줄여 정상세포에 대한 부작용을 감소시킬 수 있으므로 항암치료에 유용하게 사용될 수 있다.
• Anti-Helicobacter pylori Activity of Herbal Medicines.
  作者：Eun-Ah BAE、Myung Joo HAN、Nam-Jae KIM、Dong-Hyun KIM

  DOI：10.1248/bpb.21.990

  日期：——

  The extracts of Coptidis japonica (rhizoma), Eugenia caryophyllata (flower), Rheum palmatum (rhizoma), Magnolia officinalis (cortex) and Rhus javanica (galla rhois) potently inhibited the grow of Helicobacter pylori (HP). However, these herbal extracts showed no inhibitory effect on HP urease except Galla rhois. Among the components separated from active herbal extracts by silica gel column chromatography, the inhibitory effects of decursinal angelate and decursion on the growth of HP were the most potent, followed by magnolol, berberine, cinnamic acid, decursinol and gallic acid. Minimum inhibitory concentrations (MICs) of decursin and decursinol anglate were 6-20 μg/ml