5-Morpholin-4-yl-8-nitro-isoquinoline | 185559-72-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 5-Morpholin-4-yl-8-nitro-isoquinoline
• 英文别名: 4-(8-Nitroisoquinolin-5-yl)morpholine
• CAS: 185559-72-2
• 化学式: C₁₃H₁₃N₃O₃
• 分子量: 259.265
• InChiKey: PRCWJPDIULCBKW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  71.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  5-Morpholin-4-yl-8-nitro-isoquinoline 在 palladium on activated charcoal 氢气 作用下， 以 甲醇 为溶剂， 以69%的产率得到5-Morpholin-4-yl-isoquinolin-8-ylamine
  参考文献：
  名称：

  Syntheses and antifilarial profile of 5-amino and 5,8-diamino-isoquinoline derivatives: A new class of antifilarial agents

  摘要：

  The syntheses of 5-amino (4-12,15) and 5,g-diamino(16-17) isoquinoline derivatives, their antifilarial activity and their effect on metabolic activities of filariids are delineated. Some of the screened compounds have shown promising filaricidal response against Acanthocheilonema viteae in rodents. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/s0960-894x(96)00458-1
• 作为产物：
  描述：

  5-溴异喹啉 在 硫酸 、 sodium carbonate 、 potassium nitrate 作用下， 以 乙醇 为溶剂， 生成 5-Morpholin-4-yl-8-nitro-isoquinoline
  参考文献：
  名称：

  Syntheses and antifilarial profile of 5-amino and 5,8-diamino-isoquinoline derivatives: A new class of antifilarial agents

  摘要：

  The syntheses of 5-amino (4-12,15) and 5,g-diamino(16-17) isoquinoline derivatives, their antifilarial activity and their effect on metabolic activities of filariids are delineated. Some of the screened compounds have shown promising filaricidal response against Acanthocheilonema viteae in rodents. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/s0960-894x(96)00458-1

文献信息

• Syntheses and antifilarial profile of 5-amino and 5,8-diamino-isoquinoline derivatives: A new class of antifilarial agents
  作者：Sanjay K. Srivastava、P.M.S. Chauhan、S.K. Agarwal、A.P. Bhaduri、S.N. Singh、Nigar Fatma、R.K. Chatterjee、Chhanda Bose、V.M.L. Srivastava

  DOI：10.1016/s0960-894x(96)00458-1

  日期：1996.11

  The syntheses of 5-amino (4-12,15) and 5,g-diamino(16-17) isoquinoline derivatives, their antifilarial activity and their effect on metabolic activities of filariids are delineated. Some of the screened compounds have shown promising filaricidal response against Acanthocheilonema viteae in rodents. Copyright (C) 1996 Elsevier Science Ltd