1-(Benzyl-methyl-amino)-2-hydrazino-aethan | 3283-69-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(Benzyl-methyl-amino)-2-hydrazino-aethan
• 英文别名: 1-<2-(Benzyl-methyl-amino)-aethyl>-hydrazin；1-<(2-Chlor-benzyl)-methyl-amino>-2-hydrazino-aethan；N-(Benzyl-methyl-amino)-2-hydrazino-aethan；Methyl-(2-hydrazino-aethyl)-benzyl-amin；2-(N-Methyl-N-benzylamino)-ethylhydrazin；N-(1-Phenyl-2-propyl)aminoethylhydrazin；N-benzyl-2-hydrazinyl-N-methylethanamine
• CAS: 3283-69-0
• 化学式: C₁₀H₁₇N₃
• 分子量: 179.265
• InChiKey: NXIOUCKZOJSWKI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  41.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-(Benzyl-methyl-amino)-2-hydrazino-aethan 在 盐酸 作用下， 以 甲醇 、 水 、 丙酮 为溶剂， 反应 2.0h， 生成 2-(2-(benzyl(methyl)amino)ethyl)-2,4,6,7-tetrahydro-5H-indazol-5-one
  参考文献：
  名称：

  Novel dihydrothieno[2,3-e]indazole derivatives as IκB kinase inhibitors

  摘要：

  Synthesis, and structure-activity relationship (SAR) studies of the novel IKK-beta inhibitors 2 and 3 characterized by a dihydrothieno[2,3-e]indazole core are presented. Compound 2t was efficacious in a mouse model of LPS-stimulated TNF-alpha production. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.01.069

文献信息

• AMINE-CONTAINING LIPIDOIDS AND USES THEREOF
  申请人：Massachusetts Institute of Technology

  公开号：US20160114042A1

  公开（公告）日：2016-04-28

  Provided herein are lipidoids that may be prepared from the conjugate addition of alkylamines to acrylates. In some embodiments, provided lipidoids are biodegradable and may be used in a variety of drug delivery systems. Given the amino moiety of the lipidoids, they are well-suited for the delivery of polynucleotides, in addition to other agents. Nanoparticles containing the inventive lipidoids and polynucleotides have been prepared and have been shown to be effective in delivering siRNA.
• Novel dihydrothieno[2,3-e]indazole derivatives as IκB kinase inhibitors
  作者：Hiroyasu Takahashi、Mariko Shinoyama、Takashi Komine、Muneki Nagao、Masashi Suzuki、Hisatoshi Tsuchida、Koichi Katsuyama

  DOI：10.1016/j.bmcl.2011.01.069

  日期：2011.3

  Synthesis, and structure-activity relationship (SAR) studies of the novel IKK-beta inhibitors 2 and 3 characterized by a dihydrothieno[2,3-e]indazole core are presented. Compound 2t was efficacious in a mouse model of LPS-stimulated TNF-alpha production. (C) 2011 Elsevier Ltd. All rights reserved.