4,4'-DiBenzyl-4,4',5,5'-tetrahydro-2,2'-bioxazole

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4,4'-DiBenzyl-4,4',5,5'-tetrahydro-2,2'-bioxazole
• 英文别名: 4-benzyl-2-(4-benzyl-4,5-dihydro-1,3-oxazol-2-yl)-4,5-dihydro-1,3-oxazole
• 化学式: C₂₀H₂₀N₂O₂
• 分子量: 320.4
• InChiKey: OIEQQWQZUYZCRJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  43.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4,4'-DiBenzyl-4,4',5,5'-tetrahydro-2,2'-bioxazole 、 5’-O-(4,4’-二甲氧基三苯甲基)尿苷 、 异氰酸苯酯 、 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-phenylcarbamoyluridine 在 Copper(II) trifluoromethanesulfonate 作用下， 以 四氢呋喃 为溶剂， 反应 19.0h， 以5′-O-[bis(4-methoxyphenyl)phenylmethyl]-3′-O-phenylcarbamoyluridine were produced at the ratio of 70:30的产率得到5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-phenylcarbamoyl-uridine
  参考文献：
  名称：

  2'-HYDROXY-PROTECTED RIBONUCLEOSIDE DERIVATIVE AND PRODUCTION METHOD THEREOF

  摘要：

  本发明涉及一种通过在存在铜化合物和光学活性配体组成的金属配合物的条件下，将核苷与酰化试剂反应，制备2'-羟基保护核苷衍生物的方法。根据本发明的方法，可以从未保护2'、3'-羟基的核苷衍生物中，以良好的区域选择性轻松地制备出2'-羟基保护的核苷衍生物，该衍生物是合成寡核苷酸的重要中间体。

  公开号：

  US20110009609A1

文献信息

• [EN] METHOD FOR PRODUCING AN OPTICALLY ACTIVE NITRO COMPOUND<br/>[FR] PROCEDE DE PRODUCTION D'UN COMPOSE NITRO OPTIQUEMENT ACTIF
  申请人：CARREIRA ERICK M

  公开号：WO2004103951A1

  公开（公告）日：2004-12-02

  An optically active nitro compound having two hydrogen atoms on its α-cabon atom and having β-asymmetric carbon atom can be produced by making α, β-unsaturated nitroolefin having a hydrogen atom on its α-cabon atom react with at least two organosilicon compounds having at lest one silicon-hydrogen bond in the molecule in the presence of an asymmetric copper complex, or react with an organosilicon compound having at least one silicon-hydrogen bond in the molecule in the presence of an asymmetric copper complex and water.

  具有两个氢原子的α-碳原子和β-手性碳原子的光学活性硝基化合物可以通过使具有α-碳原子上的氢原子的α，β-不饱和硝基烯烃与至少两个分子中至少有一个硅-氢键的有机硅化合物在存在不对称铜配合物的情况下反应，或者在存在不对称铜配合物和水的情况下，使具有至少一个硅-氢键的有机硅化合物与α-碳原子上的氢原子反应来制备。
• Method for producing an optically active nitro compound
  申请人：Carreira M. Erick

  公开号：US20070037976A1

  公开（公告）日：2007-02-15

  An optically active nitro compound having two hydrogen atoms on its α-cabon atom and having β-asymmetric carbon atom can be produced by making α, β-unsaturated nitroolefin having a hydrogen atom on its α-cabon atom react with at least two organosilicon compounds having at lest one silicon-hydrogen bond in the molecule in the presence of an asymmetric copper complex, or react with an organosilicon compound having at least one silicon-hydrogen bond in the molecule in the presence of an asymmetric copper complex and water.

  具有α-碳原子上两个氢原子和β-不对称碳原子的光学活性硝基化合物可以通过使具有α-碳原子上氢原子的α，β-不饱和硝基烯与至少两种分子中具有至少一个硅-氢键的有机硅化合物在不对称铜配合物存在下反应，或在不对称铜配合物和水存在下与具有至少一个硅-氢键的有机硅化合物反应而制得。
• Polymer
  申请人：Haddleton David

  公开号：US20080300348A1

  公开（公告）日：2008-12-04

  The application provides a method of producing a comb polymer comprising the steps of: (a) Providing: (i) a plurality of monomers which are linear, branched or star-shaped, substituted or non-substituted, and have an olefinically unsaturated moiety, the olefinically unsaturated moiety being capable of undergoing addition polymerisation; (ii) an initiator compound; the initiator compound comprising a homolytically cleavable bond. (iii) a catalyst capable of catalysing the polymerisation of the monomer; and (b) Causing the catalyst to catalyse, in combination with the initiator, the polymerisation of a plurality of the monomers to produce the comb polymer. Catalysts and polymers obtainable by the process are also provided. Preferably, the comb polymer is capable of binding proteins and may be produced from monomers which are alkoxy polyethers, such as poly(alkyleneglycol) or polytetrahydrofuran.

  该应用程序提供了一种生产梳状聚合物的方法，包括以下步骤：(a) 提供：(i) 一种具有烯丙基不饱和基团的线性、支化或星形单体，取代或非取代，该烯丙基不饱和基团能够进行加成聚合；(ii) 一种引发剂化合物；该引发剂化合物包括一个均裂性可裂解键。(iii) 一种催化剂，能够催化单体的聚合；以及(b) 使催化剂与引发剂相结合，催化多种单体的聚合，从而产生梳状聚合物。该过程获得的催化剂和聚合物也被提供。优选地，该梳状聚合物能够结合蛋白质，并且可以由烷氧基聚醚单体制成，例如聚(烷基二醇)或聚四氢呋喃。
• 2′-hydroxy-protected ribonucleoside derivative and production method thereof
  申请人：Kaneka Corporation

  公开号：US08252919B2

  公开（公告）日：2012-08-28

  The present invention relates to a method for producing a 2′-hydroxy-protected nucleoside derivative by reacting a ribonucleoside with an acylating or a carbamoylating reagent in the presence of a metal complex consisting of a copper compound and an optically active ligand. By the method according to the present invention, a 2′-hydroxy-protected ribonucleoside derivative, which is an important intermediate for producing an oligonucleoside, can be easily produced with good regioselectivity from a nucleoside derivative of which 2′,3′-hydroxy groups are not protected.

  本发明涉及一种通过在铜化合物和手性配体的存在下，将核苷与酰化或氨基甲酰化试剂反应以制备2'-羟基保护核苷衍生物的方法。通过本发明的方法，可以从未保护2'、3'羟基的核苷衍生物中轻松地制备出2'-羟基保护的核苷衍生物，这是制备寡核苷酸的重要中间体，且具有良好的区域选择性。
• POLYMER
  申请人：Warwick Effect Polymers Limited

  公开号：US20130295040A1

  公开（公告）日：2013-11-07

  The application provides a method of producing a comb polymer comprising the steps of: (a) Providing: (i) a plurality of monomers which are linear, branched or star-shaped, substituted or non-substituted, and have an olefinically unsaturated moiety, the olefinically unsaturated moiety being capable of undergoing addition polymerisation; (ii) an initiator compound; the initiator compound comprising a homolytically cleavable bond. (iii) a catalyst capable of catalysing the polymerisation of the monomer; and (b) Causing the catalyst to catalyse, in combination with the initiator, the polymerisation of a plurality of the monomers to produce the comb polymer. Catalysts and polymers obtainable by the process are also provided. Preferably, the comb polymer is capable of binding proteins and may be produced from monomers which are alkoxy polyethers, such as poly(alkyleneglycol) or polytetrahydrofuran.

  该应用程序提供了一种制备梳状聚合物的方法，包括以下步骤：(a) 提供：(i) 多种单体，这些单体是线性的、分支的或星形的，取代的或非取代的，并具有烯丙基不饱和基团，烯丙基不饱和基团能够经历加成聚合；(ii) 引发剂化合物；引发剂化合物包括一个自由基裂解键；(iii) 能够催化单体聚合的催化剂；和(b) 使催化剂与引发剂结合，催化多种单体的聚合以产生梳状聚合物。该过程可获得催化剂和聚合物。优选地，梳状聚合物能够结合蛋白质，并且可以由烷氧基聚醚单体制备，例如聚(烷基二醇)或聚四氢呋喃。