N,N'-bis(4-phenyl-1,3-thiazol-2-yl)pyridine-2,6-dicarboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N,N'-bis(4-phenyl-1,3-thiazol-2-yl)pyridine-2,6-dicarboxamide
• 英文别名: 2-N,6-N-bis(4-phenyl-1,3-thiazol-2-yl)pyridine-2,6-dicarboxamide
• 化学式: C₂₅H₁₇N₅O₂S₂
• 分子量: 483.6
• InChiKey: MPIZIBPMLKGYDT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  34
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  153
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  N,N'-bis(4-phenyl-1,3-thiazol-2-yl)pyridine-2,6-dicarboxamide 在 magnesium 作用下， 以 aq. buffer 为溶剂， 生成
  参考文献：
  名称：

  10.14233/ajchem.2024.31405

  摘要：

  In this work, pyridine-2,6-dicarboxamide based ligand was synthesized by reacting pyridine-2,6-dicarboxylic acid with a thiazole derivative. The synthesized ligand was characterized by 1H NMR and 13C NMR, IR spectroscopic and mass spectrometry. The UV-visible spectrum accompanied with fluorescent spectral studies, binding constants and limit of detection proved efficient sensing abilities. The ligand was found to bind with one equivalent of an M2+ ion as validated by Job’s plot and binding parameters. The novel fluorescent probe based on amide ligand exhibits precise and selective response to Mg2+ and Ni2+ ions in HEPES buffer solution showing the detection limit to be 2.1502 × 10–8 mol/L and 4.8007 × 10–8 mol/L, respectively. The binding stoichiometry of amide ligand with Mg2+ and Ni2+ was estimated by Job’s plot method and found to be 1:1, which is further confirmed by mass spectrometry.

  DOI：

  10.14233/ajchem.2024.31405
• 作为产物：
  描述：

  吡啶-2,6-二甲酸 、 2-氨基-4-苯基噻唑 在 吡啶 、 三苯基膦 作用下， 以90 %的产率得到N,N'-bis(4-phenyl-1,3-thiazol-2-yl)pyridine-2,6-dicarboxamide
  参考文献：
  名称：

  10.14233/ajchem.2024.31405

  摘要：

  In this work, pyridine-2,6-dicarboxamide based ligand was synthesized by reacting pyridine-2,6-dicarboxylic acid with a thiazole derivative. The synthesized ligand was characterized by 1H NMR and 13C NMR, IR spectroscopic and mass spectrometry. The UV-visible spectrum accompanied with fluorescent spectral studies, binding constants and limit of detection proved efficient sensing abilities. The ligand was found to bind with one equivalent of an M2+ ion as validated by Job’s plot and binding parameters. The novel fluorescent probe based on amide ligand exhibits precise and selective response to Mg2+ and Ni2+ ions in HEPES buffer solution showing the detection limit to be 2.1502 × 10–8 mol/L and 4.8007 × 10–8 mol/L, respectively. The binding stoichiometry of amide ligand with Mg2+ and Ni2+ was estimated by Job’s plot method and found to be 1:1, which is further confirmed by mass spectrometry.

  DOI：

  10.14233/ajchem.2024.31405