2,5-Dioxopyrrolidin-1-yl 3,4,5-tris(prop-2-yn-1-yloxy)benzoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,5-Dioxopyrrolidin-1-yl 3,4,5-tris(prop-2-yn-1-yloxy)benzoate
• 英文别名: (2,5-dioxopyrrolidin-1-yl) 3,4,5-tris(prop-2-ynoxy)benzoate
• 化学式: C₂₀H₁₅NO₇
• 分子量: 381.3
• InChiKey: CPKXRSARKPOMAO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  28
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  91.4
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  3,4,5-tris(prop-2-ynyloxy)benzoic acid 、 N-羟基丁二酰亚胺 、 N,N'-二异丙基碳二亚胺 、 甲醇 在 盐酸 、 Brine 作用下， 以 二氯甲烷 为溶剂， 反应 16.0h， 生成 2,5-Dioxopyrrolidin-1-yl 3,4,5-tris(prop-2-yn-1-yloxy)benzoate
  参考文献：
  名称：

  PROTEIN BIOSENSORS, CROSS REACTIVE SENSOR ARRAYS AND METHODS OF USE THEREOF

  摘要：

  本发明涉及基于寡核苷酸交叉反应传感器阵列的荧光蛋白生物传感器，其中包括选择性和非选择性蛋白质表面结合域用于蛋白质检测。不同蛋白质亚型与本发明的传感器的相互作用产生每种蛋白质的独特光学特征。独特的光学特征允许区分密切相关的蛋白质亚型，并在生物流体中诊断与蛋白质相关的疾病和障碍。

  公开号：

  US20150362490A1

文献信息

• Protein biosensors, cross reactive sensor arrays and methods of use thereof
  申请人：YEDA RESEARCH AND DEVELOPMENT CO. LTD.

  公开号：US10281459B2

  公开（公告）日：2019-05-07

  The present invention is directed to fluorescent protein biosensors based on oligonucleotide cross reactive sensor arrays including a selective and a non-selective protein surface binding domain for protein detection. Interaction of different protein isoforms with the sensors of this invention yields a unique optical signature for each protein. The unique optical signature allows differentiating between closely related protein isoforms and diagnosing diseases and disorders associated with the proteins also in biofluids.

  本发明涉及基于寡核苷酸交叉反应传感器阵列的荧光蛋白生物传感器，该传感器阵列包括用于检测蛋白质的选择性和非选择性蛋白质表面结合域。不同蛋白质异构体与本发明传感器的相互作用可产生每种蛋白质的独特光学特征。这种独特的光学特征可用于区分密切相关的蛋白质异构体，诊断生物流体中与蛋白质相关的疾病。
• [EN] PROTEIN BIOSENSORS, CROSS REACTIVE SENSOR ARRAYS AND METHODS OF USE THEREOF<br/>[FR] BIOCAPTEURS PROTÉINIQUES, RÉSEAUX DE CAPTEURS À RÉACTION CROISÉE ET PROCÉDÉS D'UTILISATION CORRESPONDANTS
  申请人：YEDA RES & DEV

  公开号：WO2014102806A1

  公开（公告）日：2014-07-03

  The present invention is directed to fluorescent protein biosensors based on oligonucleotide cross reactive sensor arrays including a selective and a non-selective protein binding domain for protein detection. Interaction of different protein isoforms with the sensors of this invention yields a unique optical signature for each protein. The unique optical signature allows differentiating between closely related protein isoforms and diagnosing diseases and disorders associated with the proteins also in biofluids.
• PROTEIN BIOSENSORS, CROSS REACTIVE SENSOR ARRAYS AND METHODS OF USE THEREOF
  申请人：YEDA RESEARCH AND DEVELOPMENT CO. LTD.

  公开号：US20150362490A1

  公开（公告）日：2015-12-17

  The present invention is directed to fluorescent protein biosensors based on oligonucleotide cross reactive sensor arrays including a selective and a non-selective protein surface binding domain for protein detection. Interaction of different protein isoforms with the sensors of this invention yields a unique optical signature for each protein. The unique optical signature allows differentiating between closely related protein isoforms and diagnosing diseases and disorders associated with the proteins also in biofluids.

  本发明涉及基于寡核苷酸交叉反应传感器阵列的荧光蛋白生物传感器，其中包括选择性和非选择性蛋白质表面结合域用于蛋白质检测。不同蛋白质亚型与本发明的传感器的相互作用产生每种蛋白质的独特光学特征。独特的光学特征允许区分密切相关的蛋白质亚型，并在生物流体中诊断与蛋白质相关的疾病和障碍。