1-(5-Bromopyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-3-carbohydrazide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1-(5-Bromopyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-3-carbohydrazide
• 英文别名: 1-(5-bromopyridin-2-yl)-5-(trifluoromethyl)pyrazole-3-carbohydrazide
• 化学式: C₁₀H₇BrF₃N₅O
• 分子量: 350.09
• InChiKey: OMWPHIYNEFQWCP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  85.8
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  1-(5-Bromopyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-3-carbohydrazide 、 ethyl 1-(5-bromopyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-3-carboxylate 、 一水合肼 、 乙醇 在 甲苯 作用下， 反应 16.0h， 以to obtain 30 g (95%) of the title compound as a white solid的产率得到1-(5-(1-(5-Bromopyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazol-3-yl)-2,2-dimethyl-1,3,4-oxadiazol-3(2H)-yl)ethanone
  参考文献：
  名称：

  SUBSTITUTED PYRAZOLE COMPOUNDS AS CRAC MODULATORS

  摘要：

  本发明涉及描述如下式（I）的化合物及其药学上可接受的盐，其调节钙释放活化的钙（CRAC）通道的活性。本发明还描述了式（I）的化合物及其药物组合物，用于治疗、管理和/或减轻与调节钙释放活化的钙（CRAC）通道相关的疾病、疾病、综合征或病状。

  公开号：

  US20150111925A1

文献信息

• Substituted pyrazole compounds as CRAC modulators
  申请人：LUPIN LIMITED

  公开号：US09409898B2

  公开（公告）日：2016-08-09

  The present invention relates to compounds described herein Formula (I) and pharmaceutical acceptable salts thereof, which modulate the activity of calcium release-activated calcium (CRAC) channel. The invention also describes the compounds of Formula (I) and pharmaceutical compositions containing such compounds thereof for treating, managing, and/or lessening the severity of diseases, disorders, syndromes or conditions associated with the modulation of calcium release-activated calcium (CRAC) channel.

  本发明涉及描述如下式(I)的化合物及其药学上可接受的盐，其调节钙释放激活的钙(CRAC)通道的活性。该发明还描述了式(I)的化合物及含有这种化合物的药物组合物，用于治疗、管理和/或减轻与调节钙释放激活的钙(CRAC)通道相关的疾病、疾病、综合症或病症的严重程度。
• US9409898B2
  申请人：——

  公开号：US9409898B2

  公开（公告）日：2016-08-09
• [EN] SUBSTITUTED PYRAZOLE COMPOUNDS AS CRAC MODULATORS<br/>[FR] COMPOSÉS SUBSTITUÉS DE PYRAZOLE EN TANT QUE MODULATEURS DE CRAC
  申请人：LUPIN LTD

  公开号：WO2013164773A1

  公开（公告）日：2013-11-07

  The present invention relates to compounds described herein Formula (I) and pharmaceutical acceptable salts thereof, which modulate the activity of calcium release- activated calcium (CRAC) channel. The invention also describes the compounds of Formula (I) and pharmaceutical compositions containing such compounds thereof for treating, managing, and/or lessening the severity of diseases, disorders, syndromes or conditions associated with the modulation of calcium release-activated calcium (CRAC) channel.
• SUBSTITUTED PYRAZOLE COMPOUNDS AS CRAC MODULATORS
  申请人：LUPIN LIMITED

  公开号：US20150111925A1

  公开（公告）日：2015-04-23

  The present invention relates to compounds described herein Formula (I) and pharmaceutical acceptable salts thereof, which modulate the activity of calcium release-activated calcium (CRAC) channel. The invention also describes the compounds of Formula (I) and pharmaceutical compositions containing such compounds thereof for treating, managing, and/or lessening the severity of diseases, disorders, syndromes or conditions associated with the modulation of calcium release-activated calcium (CRAC) channel.

  本发明涉及描述如下式（I）的化合物及其药学上可接受的盐，其调节钙释放活化的钙（CRAC）通道的活性。本发明还描述了式（I）的化合物及其药物组合物，用于治疗、管理和/或减轻与调节钙释放活化的钙（CRAC）通道相关的疾病、疾病、综合征或病状。