(2,7-Dimethyl-imidazo[1,2-a]pyridin-3-yl)-methanol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: (2,7-Dimethyl-imidazo[1,2-a]pyridin-3-yl)-methanol
• 英文别名: (2,7-Dimethylimidazo[1,2-a]pyridin-3-yl)methanol
• 化学式: C₁₀H₁₂N₂O
• mdl: MFCD00269452
• 分子量: 176.218
• InChiKey: PFDTWSOHZOMIBM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  37.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  苄硫醇 、 (2,7-Dimethyl-imidazo[1,2-a]pyridin-3-yl)-methanol 在 溶剂黄146 作用下， 反应 2.0h， 以54%的产率得到3-Benzylsulfanylmethyl-2,7-dimethyl-imidazo[1,2-a]pyridine
  参考文献：
  名称：

  Synthesis of Imidazo[1,2-a]pyridines as Antiviral Agents

  摘要：

  The synthesis of original imidazo[1,2-a]pyridines bearing a thioether side chain at the 3 position and their antiviral activity are reported. From the synthesized compounds, 4, 15, and 21 were highly active against human cytomegalovirus with a therapeutic index superior to 150. These compounds also showed pronounced activity against varicella-zoster virus. Their structure-activity relationship is discussed.

  DOI：

  10.1021/jm981051y

文献信息

• Synthesis of Imidazo[1,2-<i>a</i>]pyridines as Antiviral Agents
  作者：Alain Gueiffier、Sylvie Mavel、Mohammed Lhassani、Ahmed Elhakmaoui、Robert Snoeck、Graciela Andrei、Olivier Chavignon、Jean-Claude Teulade、Myriam Witvrouw、Jan Balzarini、Erik De Clercq、Jean-Pierre Chapat

  DOI：10.1021/jm981051y

  日期：1998.12.1

  The synthesis of original imidazo[1,2-a]pyridines bearing a thioether side chain at the 3 position and their antiviral activity are reported. From the synthesized compounds, 4, 15, and 21 were highly active against human cytomegalovirus with a therapeutic index superior to 150. These compounds also showed pronounced activity against varicella-zoster virus. Their structure-activity relationship is discussed.