(-)-tetrahydropyran-2-yl-acetic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 英文名称: (-)-tetrahydropyran-2-yl-acetic acid
• 英文别名: (-)-Tetrahydropyran-2-yl-essigsaeure；(S)-2-(tetrahydro-2H-pyran-2-yl)acetic acid；2-[(2S)-oxan-2-yl]acetic acid
• 化学式: C₇H₁₂O₃
• 分子量: 144.17
• InChiKey: WRJWKHJGSNPGND-LURJTMIESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (-)-tetrahydropyran-2-yl-acetic acid 生成 (+)-tetrahydropyran-2-yl-acetic acid amide
  参考文献：
  名称：

  Preparation of l-2-Aminomethyltetrahydropyran¹

  摘要：

  DOI：

  10.1021/ja01126a045

文献信息

• NOVEL BENZODIOXOLE PIPERAZINE COMPOUNDS
  申请人：Rodriguez Sarmiento Rosa Maria

  公开号：US20130040948A1

  公开（公告）日：2013-02-14

  The present invention is concerned with novel dual modulators of the 5-HT 2A and D 3 receptors of formula (I) wherein n, Y, R 1 , R 2 , R 3 , and R 4 are as described herein, as well as pharmaceutically acceptable salts and esters thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions containing them and their use as pharmaceutical agents.

  本发明涉及公式(I)的新型5-HT2A和D3受体的双重调节剂，其中n、Y、R1、R2、R3和R4如本文所述，以及其药学上可接受的盐和酯。此外，本发明涉及制备公式(I)化合物、含有它们的药物组合物以及它们作为药物代理的用途。
• [EN] NOVEL BENZODIOXOLE PIPERAZINE COMPOUNDS<br/>[FR] NOUVELLES BENZODIOXOLEPIPÉRAZINES
  申请人：HOFFMANN LA ROCHE

  公开号：WO2012110470A1

  公开（公告）日：2012-08-23

  The present invention is concerned with novel dual modulators of the 5-HT2A and D3 receptors of formula (I) wherein n, Y, R1, R2, R3, and R4 are as described herein, as well as pharmaceutically acceptable salts and esters thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments.

  本发明涉及一种新颖的5-HT2A和D3受体的双调节剂，其化学式为(I)，其中n、Y、R1、R2、R3和R4如本文所述，以及其药用盐和酯。此外，本发明涉及化合物的制备，包括它们的药物组合物以及它们作为药物的用途。
• [EN] NOVEL BENZODIOXOLE PIPERIDINE COMPOUNDS<br/>[FR] NOUVEAUX COMPOSÉS BENZODIOXOLE PIPÉRIDINE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2012117001A1

  公开（公告）日：2012-09-07

  The present invention is concerned with novel dual modulators of the 5-HT2A and D3 receptors of formula (I) wherein n, Y, R1, R2, R3, and R4 are as described herein, as well as pharmaceutically acceptable salts and esters thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments.

  本发明涉及公式（I）中5-HT2A和D3受体的新型双调节剂，其中n、Y、R1、R2、R3和R4如本文所述，以及其药学上可接受的盐和酯。此外，本发明涉及制备公式（I）化合物、包含它们的药物组合物以及它们作为药物的用途。
• NOVEL BENZODIOXOLE PIPERIDINE COMPOUNDS
  申请人：Rodriguez Sarmiento Rosa Maria

  公开号：US20120225868A1

  公开（公告）日：2012-09-06

  The present invention is concerned with novel dual modulators of the 5-HT 2A and D 3 receptors of formula (I) wherein n, Y, R 1 , R 2 , R 3 , and R 4 are as described herein, as well as pharmaceutically acceptable salts and esters thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions containing them and their use as pharmaceuticals.

  本发明涉及一种新颖的5-HT2A和D3受体的双重调节剂，其化学式为（I），其中n、Y、R1、R2、R3和R4如本文所述，以及其药学上可接受的盐和酯。此外，本发明涉及化合物（I）的制备、含有它们的药物组合物以及它们作为药物的用途。
• Benzodioxole piperidine compounds
  申请人：Rodriguez Sarmiento Rosa Maria

  公开号：US08598357B2

  公开（公告）日：2013-12-03

  The present invention is concerned with novel dual modulators of the 5-HT2A and D3 receptors of formula (I) wherein n, Y, R1, R2, R3, and R4 are as described herein, as well as pharmaceutically acceptable salts and esters thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions containing them and their use as pharmaceuticals.

  本发明涉及一种新型的5-HT2A和D3受体的双重调节剂，其化学式为(I)，其中n、Y、R1、R2、R3和R4如本文所述，以及其药学上可接受的盐和酯。此外，本发明涉及制备化合物(I)、含有它们的制药组合物以及它们作为药物的用途。