(+)-tetrahydropyran-2-yl-acetic acid amide | 98435-78-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 英文名称: (+)-tetrahydropyran-2-yl-acetic acid amide
• 英文别名: (+)-Tetrahydropyran-2-yl-essigsaeure-amid；2-[(2S)-oxan-2-yl]acetamide
• CAS: 98435-78-0
• 化学式: C₇H₁₃NO₂
• 分子量: 143.186
• InChiKey: XULRXAPRWPCLBL-LURJTMIESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  52.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (-)-tetrahydropyran-2-yl-acetic acid 生成 (+)-tetrahydropyran-2-yl-acetic acid amide
  参考文献：
  名称：

  Preparation of l-2-Aminomethyltetrahydropyran¹

  摘要：

  DOI：

  10.1021/ja01126a045

文献信息

• NOVEL BENZODIOXOLE PIPERAZINE COMPOUNDS
  申请人：Rodriguez Sarmiento Rosa Maria

  公开号：US20130040948A1

  公开（公告）日：2013-02-14

  The present invention is concerned with novel dual modulators of the 5-HT 2A and D 3 receptors of formula (I) wherein n, Y, R 1 , R 2 , R 3 , and R 4 are as described herein, as well as pharmaceutically acceptable salts and esters thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions containing them and their use as pharmaceutical agents.

  本发明涉及公式(I)的新型5-HT2A和D3受体的双重调节剂，其中n、Y、R1、R2、R3和R4如本文所述，以及其药学上可接受的盐和酯。此外，本发明涉及制备公式(I)化合物、含有它们的药物组合物以及它们作为药物代理的用途。
• PIPERAZINE D3 AND 5-HT2A RECEPTOR MODULATORS
  申请人：F. Hoffmann-La Roche AG

  公开号：EP2334657A1

  公开（公告）日：2011-06-22
• US8722683B2
  申请人：——

  公开号：US8722683B2

  公开（公告）日：2014-05-13
• [EN] PIPERAZINE D3 AND 5-HT2A RECEPTOR MODULATORS<br/>[FR] MODULATEURS DES RÉCEPTEURS D3 ET 5-HT2A DÉRIVÉS DE PIPÉRAZINE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2010031735A1

  公开（公告）日：2010-03-25

  The present invention relates to compounds of the general formula (I) (I) wherein X, n and R1 are as described herein, as well as pharmaceutically acceptable salts and esters thereof, as well as their manufacture, pharmaceutical compositions containing them and their use as medicaments. The active compounds of the present invention are dual modulators of the serotonin 5-HT2a and dopamine D3 receptors, useful in the treatment and/or the prevention of cognitive disorders, drug addiction, depression, anxiety, drug dependence, dementias, memory impairment, psychotic disorders comprising schizophrenia, schizoaffective disorders, bipolar disease, mania, psychotic depression, and psychoses comprising paranoia and delusions.
• Preparation of l-2-Aminomethyltetrahydropyran¹
  作者：Robert P. Zelinski、Norman G. Peterson、Hope R. Wallner

  DOI：10.1021/ja01126a045

  日期：1952.3