3-(4-Methyl-furazan-3-yl)-propionic acid ethyl ester

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 3-(4-Methyl-furazan-3-yl)-propionic acid ethyl ester
• 英文别名: Ethyl 3-(4-methyl-1,2,5-oxadiazol-3-yl)propanoate
• 化学式: C₈H₁₂N₂O₃
• mdl: MFCD03990561
• 分子量: 184.195
• InChiKey: ZFZKUQWGWCCGPT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.625
• 拓扑面积：
  65.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  3,4-二甲基-1,2,5-噁二唑 、 溴乙酸乙酯 在 正丁基锂 作用下， 生成 3-(4-Methyl-furazan-3-yl)-propionic acid ethyl ester
  参考文献：
  名称：

  Organometallic synthesis in the furazan series 1. Functionalization of 3-methyl-4-R-furazans

  摘要：

  The possibility of synthesizing functionally substituted furazans by alkylation of lithium derivatives of 3-methyl-4-R-furazans was investigated. It was shown that one or both methyl groups of 3,4-dimethylfurazan could be lithiated and alkylated. A series of previously unknown furazan derivatives was obtained.

  DOI：

  10.1007/bf00869515

文献信息

• Organometallic synthesis in the furazan series 1. Functionalization of 3-methyl-4-R-furazans
  作者：A. Yu. Sizov、A. B. Sheremetev

  DOI：10.1007/bf00869515

  日期：1992.2

  The possibility of synthesizing functionally substituted furazans by alkylation of lithium derivatives of 3-methyl-4-R-furazans was investigated. It was shown that one or both methyl groups of 3,4-dimethylfurazan could be lithiated and alkylated. A series of previously unknown furazan derivatives was obtained.