CK944

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: CK944
• 英文别名: 3-(1H-phenanthro[9,10-d]imidazol-2-yl)-phenol；3-(1H-phenanthro[9,10-d]imidazol-2-yl)phenol
• 化学式: C₂₁H₁₄N₂O
• 分子量: 310.355
• InChiKey: IFXICQCGQIZYEC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  24
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  48.9
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  ammonium acetate 、 间羟基苯甲醛 、 菲醌 生成 CK944
  参考文献：
  名称：

  Reactions of Phenanthraquinone and Retenequinone with Aldehydes and Ammonium Acetate in Acetic Acid Solution¹

  摘要：

  DOI：

  10.1021/ja01243a043

文献信息

• ARYL IMIDAZOLES AND THEIR USE AS ANTI-CANCER AGENTS
  申请人：Lorus Therapeutics Inc.

  公开号：EP1692113B1

  公开（公告）日：2017-09-27
• 2, 4, 5 - Trisubstituted Imidazoles And Their Use As Anti-Microbial Agents
  申请人：Al-Qawasmeh Raed

  公开号：US20070105929A1

  公开（公告）日：2007-05-10

  The present invention provides therapeutically effective 2,4,5-trisubstituted imidazole compounds, methods of preparing the same, and compositions comprising the compounds alone or in combination with other agents. The present invention further provides for the use of the compounds as anti-microbial agents. The anti-microbial properties of the compounds include anti-bacterial and/or anti-fungal activity.
• Aryl imidazoles and their use as anti-cancer agents
  申请人：Huesca Mario

  公开号：US20070123553A1

  公开（公告）日：2007-05-31

  Therapeutically effective 2,4,5-trisubstituted imidazole compounds are provided. Also provided are methods -of preparing the compounds and pharmaceutical compositions comprising the compounds alone or in combination with other agents. The present invention further provides for the use of the compounds as anti-cancer agents; wherein: R1 is aryl, substituted aryl, heterocycle, substituted heterocycle, heteroaryl, substituted heteroaryl or amino; R2 and R3 are independently aryl, substituted aryl, heterocycle, heteroaryl, substituted heterocycle, or substituted heteroaryl or R2 and R3 when taken together along with the carbon atoms they are attached to, form aryl or substituted aryl, and R4 is hydrogen, halogen, hydroxyl, thiol, lower alkyl, substituted lower alkyl, lower alkenyl, substituted lower alkenyl, lower alkynyl, substituted lower alkynyl, alkylalkenyl, alkyl alkynyl, alkoxy, alkylthio, aryl, aryloxy, amino, amido, carboxyl, aryl, substituted aryl, heterocycle, heteroaryl, substituted heterocycle, heteroalkyl, cycloalkyl, substituted cycloalkyl, alkylcycloalkyl, alkylcycloheteroalkyl, nitro, cyano or —S(O)o.2R wherein R is alkyl, substituted alkyl, aryl, substituted aryl, heterocycle, heteroaryl, substituted heterocycle, or substituted heteroaryl.
• 2,4,5-TRISUBSTITUTED IMIDAZOLES AND THEIR USE AS ANTI-MICROBIAL AGENTS
  申请人：AL-QAWASMEH RAED H.

  公开号：US20110152337A1

  公开（公告）日：2011-06-23

  The present invention provides therapeutically effective 2,4,5-trisubstituted imidazole compounds, methods of preparing the same, and compositions comprising the compounds alone or in combination with other agents. The present invention further provides for the use of the compounds as anti-microbial agents. The anti-microbial properties of the compounds include anti-bacterial and/or anti-fungal activity.
• US7884120B2
  申请人：——

  公开号：US7884120B2

  公开（公告）日：2011-02-08