The invention relates to novel chemical compounds, compositions and methods of making and using the same. In particular, the invention provides pyridazine compounds and/or related heterocyclic derivatives, compositions comprising the same, and methods of making and using pyridazine compounds and/or related heterocyclic derivatives and compositions comprising the same, for modulation of cellular pathways (e.g., signal transduction pathways), for treatment or prevention of inflammatory diseases (e.g., Alzheimer's disease), for research, drug screening, and therapeutic applications.
Compounds of Formula Ia or Ib
or
wherein R is a substituted amino group, R2 is an unsaturated 5 to 6-membered heteromonocyclic group containing 1 to 4 nitrogen atoms, R3, R4, R5, and R6 are hydrogen, and R7 is absent; or a pharmaceutically acceptable salt thereof.
本发明涉及新型化合物、组合物及其制造和使用方法。特别是,本发明提供了
哒嗪化合物和/或相关杂环衍
生物、包含这些化合物的组合物,以及制造和使用
哒嗪化合物和/或相关杂环衍
生物及包含这些化合物的组合物的方法,用于调节细胞通路(如
信号转导通路)、治疗或预防炎症性疾病(如阿尔茨海默氏症)、研究、药物筛选和治疗应用。
式 Ia 或 Ib 的化合物
或
其中 R 是取代的
氨基,R2 是含有 1 至 4 个
氮原子的不饱和 5 至 6 元杂环基团,R3、R4、R5 和 R6 是
氢,R7 不存在;或其药学上可接受的盐。