2-Methyl-3-hydroxy-4,5-bis-brommethyl-pyridin | 55652-71-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-Methyl-3-hydroxy-4,5-bis-brommethyl-pyridin
• 英文别名: 2-Methyl-3-hydroxy-4,5-di-(brom-methyl)-pyridin；3-Hydroxy-2-methyl-4,5-bis-brommethyl-pyridin；4,5-Bis(bromomethyl)-2-methylpyridin-3-ol
• CAS: 55652-71-6
• 化学式: C₈H₉Br₂NO
• 分子量: 294.974
• InChiKey: JHKDTHSEZFJAMJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  33.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-Methyl-3-hydroxy-4,5-bis-brommethyl-pyridin 、 间氨基三氟甲苯 生成 6-methyl-2-[3-(trifluoromethyl)phenyl]-1,3-dihydropyrrolo[3,4-c]pyridin-7-ol
  参考文献：
  名称：

  KORUNCEV, D.;PAVLOV, L.;BLAZEVIC, N.;BABIC, I.;STANOJEVIC, D.;JAKOVINA, M+, FARM. GLAS., 1983, 39, N 9, 265-274

  摘要：

  DOI：
• 作为产物：
  描述：

  2-甲基-3-羟基-4,5-二羟甲基吡啶 生成 2-Methyl-3-hydroxy-4,5-bis-brommethyl-pyridin
  参考文献：
  名称：

  KORUNCEV, D.;PAVLOV, L.;BLAZEVIC, N.;BABIC, I.;STANOJEVIC, D.;JAKOVINA, M+, FARM. GLAS., 1983, 39, N 9, 265-274

  摘要：

  DOI：

文献信息

• [EN] 1,3 DIHYDROFURO [3,4-c]PYRIDINES AND THEIR PREPARATION<br/>[FR] 1,3 DIHYDROFURO [3,4-C]PYRIDINES ET PROCEDE PERMETTANT DE LES PREPARER
  申请人：DSM IP ASSETS BV

  公开号：WO2005090356A1

  公开（公告）日：2005-09-29

  The present invention relates to novel 1,3-dihydrofuro[3,4-c]pyridines which are useful intermediates in the synthesis of pyridoxines and a method for their preparation by cobalt(I) complex-catalysed [2 + 2 + 2]-cycloaddition of di-[(3-dimethyl-C1-4-alkoxysilyl)­2-propynyl)] ethers with acetonitrile.

  本发明涉及新型1,3-二氢呋喃[3,4-c]吡啶，该吡啶是有用的中间体，用于合成维生素B6（吡哆醇），以及一种通过钴(I)配合物催化的[2 + 2 + 2]-环加成反应，将二[(3-二甲基-C1-4-烷氧基硅基)-2-丙炔基]醚与乙腈制备它们的方法。
• Compositions and methods for reducing the risk of epileptic occurrence and/or for treatment of seizure disorders
  申请人：Dolina Svetlana

  公开号：US20060235000A1

  公开（公告）日：2006-10-19

  The present invention relates to compounds and compositions useful for reducing the risk of epileptic occurrences and/or for alleviating epileptic phenomena in patients. In accordance with the invention, the compounds and compositions have at least the following two components: a) vitamin B6-based component selected from pyridoxal, pyridoxamine, pyridoxine, their pharmaceutically acceptable functional derivatives and salts; and b) at least one antiepileptic drug (AED) or anticonvulsive, neuro-protective drug or nootrope compound or moiety. The invention further relates to methods for preventing epileptic episodes and for alleviating epileptic episodes, as well as methods for reducing side effects of antiepileptic drugs.

  本发明涉及化合物和组合物，用于降低癫痫发作的风险和/或缓解患者的癫痫现象。根据本发明，化合物和组合物至少具有以下两个成分：a）基于维生素B6的组分，所选自吡哆醛、吡哆胺、吡哆醇、它们的药用可接受的功能衍生物和盐；以及b）至少一种抗癫痫药物（AED）或抗惊厥、神经保护药物或智力药物化合物或基团。本发明还涉及预防癫痫发作和缓解癫痫发作的方法，以及减少抗癫痫药物的副作用的方法。
• EP1654231A4
  申请人：——

  公开号：EP1654231A4

  公开（公告）日：2009-03-11
• COMPOSITIONS AND METHODS FOR REDUCING THE RISK OF EPILEPTIC OCCURRENCE AND/OR FOR TREATMENT OF SEIZURE DISORDERS
  申请人：D-Pharm Ltd.

  公开号：EP1654231A2

  公开（公告）日：2006-05-10
• CONJUGATE COMPOUNDS AND METHODS FOR REDUCING THE RISK OF EPILEPTIC OCCURRENCE OR FOR TREATMENT OF SEIZURE DISORDERS
  申请人：D-Pharm Ltd.

  公开号：EP1654231B1

  公开（公告）日：2012-02-01