5-氯-2-(甲基磺酰基)苯胺 | 29124-54-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 5-氯-2-(甲基磺酰基)苯胺
• 英文名称: 5-Chlor-2-methylsulfonylanilin
• 英文别名: 5-chloro-2-methanesulfonyl-aniline；5-Chlor-2-methylsulfon-anilin；Methyl-(4-chlor-2-amino-phenyl)-sulfon；5-Chlor-2-methansulfonyl-anilin；5-Chloro-2-(methylsulfonyl)aniline；5-chloro-2-methylsulfonylaniline
• CAS: 29124-54-7
• 化学式: C₇H₈ClNO₂S
• 分子量: 205.665
• InChiKey: GZPZIEPSQSEDLT-UHFFFAOYSA-N

物化性质

• 熔点：
  87-88 °C
• 沸点：
  405.4±45.0 °C(Predicted)
• 密度：
  1.414±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  68.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  5-氯-2-甲基磺酰基硝基苯 生成 5-氯-2-(甲基磺酰基)苯胺
  参考文献：
  名称：

  US1939416

  摘要：

  公开号：

文献信息

• [EN] NEW SUBSTITUTED CYANOINDOLINE DERIVATIVES AS NIK INHIBITORS<br/>[FR] NOUVEAUX DÉRIVÉS DE CYANOINDOLINE UTILISÉS COMME INHIBITEURS DE NIK
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2017125530A1

  公开（公告）日：2017-07-27

  The present invention relates to pharmaceutical agents of formula (I) useful for therapy and/or prophylaxis in a mammal, and in particular to inhibitors of NF- KB-inducing kinase (NIK - also known as MAP3K14) useful for treating diseases such as cancer, inflammatory disorders, metabolic disorders and autoimmune disorders. The invention is also directed to pharmaceutical compositions comprising such compounds, and to the use of such compounds or pharmaceutical compositions for the prevention or treatment of diseases such as cancer, inflammatory disorders, metabolic disorders including obesity and diabetes, and autoimmune disorders.

  本发明涉及一种公式（I）的药物制剂，用于治疗和/或预防哺乳动物中的疾病，特别是用于治疗癌症、炎症性疾病、代谢性疾病和自身免疫性疾病的NF-KB诱导激酶（NIK，也称为MAP3K14）的抑制剂。该发明还涉及包含这些化合物的药物组合物，以及利用这些化合物或药物组合物预防或治疗癌症、炎症性疾病、包括肥胖和糖尿病在内的代谢性疾病以及自身免疫性疾病的用途。
• Proximity effects in diaryl derivatives. Part VI. Base-catalysed rearrangement of 2-(hydroxyamino)aryl aryl sulphones to 2-hydroxy-2′-(arylsulphonyl)azoxybenzenes
  作者：M. F. Grundon、D. J. Maitland、W. L. Matier

  DOI：10.1039/j39710000654

  日期：——

  Treatment of 2-(hydroxyamino)aryl phenyl sulphones or bis-(2-hydroxyaminoaryl) sulphones with aqueous sodium hydroxide at 20° gives 2-hydroxy-2′-(arylsulphonyl)azoxybenzenes (V) and (VII) and arenesulphonate anions. The hydroxy-group in the azoxy-product is derived from the sulphone or hydroxyamino-groups and not from the added base. 2-Nitrosoaryl phenyl sulphones, 2,2′-bis(arylsulphonyl)azoxybenzenes, and

  在20°下用氢氧化钠水溶液处理2-（羟基氨基）芳基苯基砜或双-（2-羟基氨基芳基）砜，得到2-羟基-2'-（芳基磺酰基）az氧基苯（V）和（VII）和芳磺酸根阴离子。叠氮产物中的羟基衍生自砜或羟氨基，而不是所添加的碱。显示2-亚硝基芳基苯基砜，2,2'-双（芳基磺酰基）氮杂苯和2-亚硝基苯酚不是中间体。
• Substituted cyanoindoline derivatives as NIK inhibitors
  申请人：Janssen Pharmaceutica NV

  公开号：US11180487B2

  公开（公告）日：2021-11-23

  The present invention relates to pharmaceutical agents of formula (I) useful for therapy and/or prophylaxis in a mammal, and in particular to inhibitors of NF-κB-inducing kinase (NIK—also known as MAP3K14) useful for treating diseases such as cancer, inflammatory disorders, metabolic disorders and autoimmune disorders. The invention is also directed to pharmaceutical compositions comprising such compounds, and to the use of such compounds or pharmaceutical compositions for the prevention or treatment of diseases such as cancer, inflammatory disorders, metabolic disorders including obesity and diabetes, and autoimmune disorders.

  本发明涉及用于哺乳动物治疗和/或预防的式(I)药物制剂，特别是用于治疗癌症、炎症性疾病、代谢性疾病和自身免疫性疾病等疾病的NF-κB诱导激酶（NIK-又称MAP3K14）抑制剂。本发明还涉及包含此类化合物的药物组合物，以及使用此类化合物或药物组合物预防或治疗癌症、炎症性疾病、代谢紊乱（包括肥胖和糖尿病）和自身免疫性疾病等疾病。
• NEW SUBSTITUTED CYANOINDOLINE DERIVATIVES AS NIK INHIBITORS
  申请人：Janssen Pharmaceutica NV

  公开号：US20210087182A1

  公开（公告）日：2021-03-25

  The present invention relates to pharmaceutical agents of formula (I) useful for therapy and/or prophylaxis in a mammal, and in particular to inhibitors of NF- K B-inducing kinase (NIK—also known as MAP3K14) useful for treating diseases such as cancer, inflammatory disorders, metabolic disorders and autoimmune disorders. The invention is also directed to pharmaceutical compositions comprising such compounds, and to the use of such compounds or pharmaceutical compositions for the prevention or treatment of diseases such as cancer, inflammatory disorders, metabolic disorders including obesity and diabetes, and autoimmune disorders.
• US1939416
  申请人：——

  公开号：——

  公开（公告）日：——