羊毛硫氨酸酮亚胺 | 83711-67-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 羊毛硫氨酸酮亚胺
• 英文名称: lanthionine ketimine
• 英文别名: 3,6-dihydro-2H-1,4-thiazine-3,5-dicarboxylic acid
• CAS: 83711-67-5
• 化学式: C₆H₇NO₄S
• 分子量: 189.192
• InChiKey: XIVVIYYWXOMYOD-UHFFFAOYSA-N

物化性质

• 物理描述：
  Solid

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  112
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  羊毛硫氨酸酮亚胺 在 sodium cyanoborohydride 作用下， 生成 1,4-硫代吗啉-3,5-二羧酸
  参考文献：
  名称：

  WO2007/82208

  摘要：

  公开号：

文献信息

• LANTHIONINE-RELATED COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISEASES
  申请人：Hensley Kenneth

  公开号：US20070197515A1

  公开（公告）日：2007-08-23

  The present invention provides compositions comprising lanthionine ketimine derivatives and thiomorpholine dicarboxylic acid derivatives, as well as processes for the preparation of such compounds. The invention also concerns the use of lanthionine, lanthionine ketimine (LK), LK derivatives, thiomorpholine dicarboxylic acid (TMDCA), and TMDCA derivatives. It concerns the use of these compounds for the treatment and/or prevention diseases, including diseases affecting the central nervous system. The invention provides for compounds and methods having anti-oxidant, anti-neuroinflammatory and neuroprotective activities. It also provides for compounds having the ability to pass through and/or be transported through cellular membranes, such the blood-brain barrier.
• Glutathione-Lanthionine Compounds and Methods Related Thereto
  申请人：Hensley Kenneth

  公开号：US20130209366A1

  公开（公告）日：2013-08-15

  The present invention concerns glutathione-lanthionine compounds, the process of preparing such compounds, and their use. The invention also concerns methods of using the compounds and derivatives and combinations of these compounds in the treatment and/or prevention diseases, including diseases affecting the central nervous system.
• US7683055B2
  申请人：——

  公开号：US7683055B2

  公开（公告）日：2010-03-23
• [EN] LANTHIONINE-RELATED COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISEASES<br/>[FR] COMPOSÉS APPARENTÉS À LA LANTHIONINE POUR LE TRAITEMENT DE MALADIES INFLAMMATOIRES
  申请人：OKLAHOMA MED RES FOUND

  公开号：WO2007082208A2

  公开（公告）日：2007-07-19

  [EN] The present invention provides compositions comprising lanthionine ketimine derivatives and thiomorpholine dicarboxylic acid derivatives, as well as processes for the preparation of such compounds. The invention also concerns the use of lanthionine, lanthionine ketimine (LK), LK derivatives, thiomorpholine dicarboxylic acid (TMDCA), and TMDCA derivatives. It concerns the use of these compounds for the treatment and/or prevention diseases, including diseases affecting the central nervous system. The invention provides for compounds and methods having antioxidant, anti-neuroinflammatory and neuroprotective activities. It also provides for compounds having the ability to pass through and/or be transported through cellular membranes, such the blood-brain barrier.
  [FR] La présente invention concerne des compositions comprenant des dérivés de lanthionine-cétimine et des dérivés d'acide thiomorpholine-dicarboxylique, ainsi que des procédés pour la préparation de tels composés. L'invention concerne également l'utilisation de lanthionine, de lanthionine-cétimine (LK), de dérivés de LK, d'acide thiomorpholine-dicarboxylique (TMDCA) et de dérivés de TMDCA. L'invention concerne l'utilisation de ces composés pour le traitement et/ou la prévention de maladies, dont des maladies affectant le système nerveux central. L'invention concerne des composés et des procédés ayant des effets antioxydants, anti-neuro-inflammatoires et neuroprotecteurs. L'invention concerne également des composés susceptibles de passer à travers ou d'être transportés à travers les membranes cellulaires, telles que la barrière hémato-encéphalique.
• WO2007/82208
  申请人：——

  公开号：——

  公开（公告）日：——