Azanium;2-dodecoxyethyl sulfate | 32612-48-9

• 物质功能分类: 催化剂及助剂 - 聚合物
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机硫酸及其衍生物
• 英文名称: Azanium;2-dodecoxyethyl sulfate
• CAS: 32612-48-9
• 化学式: C14H33NO5S
• 分子量: 327.48
• InChiKey: OPVLOHUACNWTQT-UHFFFAOYSA-N

物化性质

• LogP：
  5.405 (est)

计算性质

• 辛醇/水分配系数(LogP)：
  3.91
• 重原子数：
  21
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  82.2
• 氢给体数：
  2
• 氢受体数：
  6

ADMET

代谢

亚硝胺可以通过摄入、吸入或皮肤接触进入人体。一旦进入人体，亚硝胺会被细胞色素P-450酶代谢，这实际上会将它们激活成致癌物质。

Nitrosamines can enter the body via ingestion, inhalation, or dermal contact. Once in the body, nitrosamines are metabolized by cytochrome P-450 enzymes, which essentially activates them into carcinogens. (A2878, A2879)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 毒性总结

虽然月桂醇聚氧乙烯醚硫酸铵本身并不有毒，但它是一种亚硝化剂。亚硝化剂可能会分解和/或反应导致亚硝胺污染。亚硝胺是在亚硝酸盐离子存在的情况下由二级胺和酰胺产生的，并且被认为具有致癌性。一旦进入人体，亚硝胺会被细胞色素P-450酶激活。然后它们被认为通过在氮和氧原子上形成DNA加合物来诱导其致癌作用。(L1889, L1890, A2878, A2879, A2880)

While ammonium laureth sulfate itself is not toxic, it is a nitrosating agent. Nitrosating agents may decompose and/or react to cause nitrosamine contamination. Nitrosamines are produced from secondary amines and amides in the presence of nitrite ions and are believed to be carcinogenic. Once in the body, nitrosamines are activated by cytochrome P-450 enzymes. They are then believed to induce their carcinogenic effects by forming DNA adducts at the N- and O-atoms. (L1889, L1890, A2878, A2879, A2880)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 致癌物分类

未列入国际癌症研究机构(IARC)名录。某些亚硝胺被IARC分类为对人类可能是或可能具有致癌性（分别为2A组和2B组）。

Not listed by IARC. Certain nitrosamines are classified by IARC as either probably or possibly carcinogenic to humans (Groups 2A and 2B, respectively). (L135)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 健康影响

月桂醇聚氧乙烯醚硫酸铵本身只会引起轻微的刺激。然而，它可能会反应产生被认为是致癌物的亚硝胺。(L1888, L1890)

Ammonium laureth sulfate itself only causes mild irritation. However, it may react to produce nitrosamines, which are believed to be carcinogenic. (L1888, L1890)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 暴露途径

口服（A2880）；吸入（A2880）；皮肤给药（L1889）

Oral (A2880) ; inhalation (A2880) ; dermal (L1889)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 症状

月桂醇聚氧乙烯醚硫酸铵可能会引起轻微刺激。

Ammonium laureth sulfate can cause mild irritation. (L1888)

来源:Toxin and Toxin Target Database (T3DB)

反应信息

• 作为反应物：
  描述：

  苯乙烯 、 1,3-丁二烯 、 丙烯酸 、 Azanium;2-dodecoxyethyl sulfate 、 环氧乙烷 、 sodium hydroxide 、 disodium;sulfonatooxy sulfate 在 1,3-丁二烯 作用下， 以 水 为溶剂， 反应 4.0h， 生成 styrene-butadiene
  参考文献：
  名称：

  Method of reducing the quantity of residual monomers in aqueous dispersions of polymers

  摘要：

  一种用于减少水性聚合物分散体中残留单体量的工艺，通过使用一个启动剂系统进行后处理，该启动剂系统基本上包括a) 占用聚合物分散体制备所用的总单体量的0.001至5重量％的氧化剂R1OOH，其中R1是氢或C1-C8烷基或C6-C12芳基，和/或a2) 在水介质中释放过氧化氢的化合物，以及b) 占用聚合物分散体制备所用的总单体量的0.005至5重量％的α-羟基羰基化合物，其中R2和R3独立地是氢和/或C1-C12烷基，可以含有功能基团和/或可以具有烯丙基不饱和度，或者R2和R3可选择通过亚甲基基团形成可能含有功能基团和/或可能具有烯丙基不饱和度的环结构，和/或b2) 在水介质中释放此类α-羟基羰基化合物的化合物，以及c) 优选地，能够存在于多种价态的多价金属离子的催化量。

  公开号：

  US06365709B1

文献信息

• High lather conditioning shampoos with improved deposition of insoluble,
  申请人：The Procter & Gamble Company

  公开号：US05648323A1

  公开（公告）日：1997-07-15

  Provided are high lathering, conditioning shampoo compositions with improved deposition of nonvolatile, insoluble, dispersed phase fluid conditioning agent, said compositions comprising: (a) from about 5% to about 29.5%, by weight, of anionic surfactant selected from the group consisting of alkyl sulfates and alkyl ethoxylated sulfates, acids thereof, and mixtures thereof; (b) from about 0.5% to about 5%, by weight, of N-acylamino acid anionic surfactant and salts thereof; (c) from about 0.05% to about 10%, by weight, of nonvolatile, insoluble fluid conditioning agent dispersed in said composition; (d) from about 0.5% to about 10%, by weight, of crystalline suspending agent for said dispersed conditioning agent; (e) from about 40% to about 89%, by weight, of water; wherein the total detersive surfactant concentration in said composition is from about 10% to about 30%; the weight ratio of component (b):component (a) is at least about 1:20; and said composition is substantially free of betaine surfactants and alkanol amide foam boosters.

  提供了一种高泡沫、调理的洗发水配方，具有改善非挥发性、不溶性、分散相流体调理剂的沉积的特点，该配方包括：(a)约5%至约29.5%重量的阴离子表面活性剂，所述阴离子表面活性剂选自烷基硫酸盐和烷基乙氧基硫酸盐，其酸和混合物；(b)约0.5%至约5%重量的N-酰基氨基酸阴离子表面活性剂及其盐；(c)约0.05%至约10%重量的非挥发性、不溶性流体调理剂分散在该配方中；(d)约0.5%至约10%重量的晶体悬浮剂，用于悬浮所述分散的调理剂；(e)约40%至约89%重量的水；其中，该配方中总洗涤表面活性剂浓度约为10%至30%；组分(b)：组分(a)的重量比至少为1：20；且该配方基本上不含有甜菜碱表面活性剂和脂肪醇酰胺泡沫增强剂。
• Method for reducing the quantity of residual monomers in aqueous polymeric dispersions
  申请人：BASF Aktiengesellschaft

  公开号：US06433132B1

  公开（公告）日：2002-08-13

  A process for reducing the amount of residual monomer in aqueous polymer dispersions operates by aftertreatment with an initiator system essentially comprising a) from 0.001 to 5% by weight, based on the total monomer amount used to prepare the polymer dispersion, a1) of an oxidizing agent R1OOH,  where R1 is hydrogen or a C1-C8-alkyl or a C6-C12-aryl group, and/or a2) of a compound which in aqueous medium releases hydrogen peroxide, and b) from 0.005 to 5% by weight, based on the total monomer amount used to prepare the polymer dispersion, of a reducing agent prepared from b1) an aldehyde R2CH═O,  where R2 is a C1-C12-alkyl group which may contain functional groups and/or may be olefinically unsaturated, and b2) an inorganic dithionite, and c) catalytic amounts of a polyvalent metal ion which is able to exist in a plurality of valence states.

  一种用于减少水性聚合物分散液中残留单体量的处理过程，通过使用基本上包括以下成分的引发体系进行后处理： a) 基于用于制备聚合物分散液的总单体量，从0.001到5%的重量份，其中a1）为氧化剂R1OOH，其中R1为氢或C1-C8烷基或C6-C12芳基，和/或a2）为在水介质中释放过氧化氢的化合物，并且 b) 基于用于制备聚合物分散液的总单体量，从0.005到5%的重量份，其中b1）为醛R2CH═O，其中R2为C1-C12烷基，可以含有官能团和/或可以是烯丙基不饱和的，和b2）为无机二硫代硫酸盐，并且 c) 催化量的多价金属离子，能够存在于多个价态。
• Antiseptic compositions and methods
  申请人：3M Innovative Properties Company

  公开号：EP1955594A1

  公开（公告）日：2008-08-13

  The present invention relates to an antiseptic composition comprising an antimicrobial agent selected from the group consisting of I2, an iodophor, and a combination thereof, wherein the antimicrobial agent is present in an amount sufficient to provide an available iodine concentration of at least about 0.25 wt-%; a hydroxycarboxylic acid buffer in an amount in excess of 5 wt-%; and water.

  本发明涉及一种防腐组合物，该组合物包含一种选自由 I2、碘伏及其组合组成的组的抗菌剂，其中抗菌剂的用量足以提供至少约 0.25 wt-% 的可用碘浓度；一种用量超过 5 wt-% 的羟基羧酸缓冲剂；以及水。
• ANTIBACTERIAL MILD LIQUID SKIN CLEANSER
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：EP0580814A1

  公开（公告）日：1994-02-02
• ANTISEPTIC COMPOSITIONS AND METHODS
  申请人：3M Innovative Properties Company

  公开号：EP1465491B1

  公开（公告）日：2009-01-21