N-(3,4-dichlorophenyl)hexanamide | 2150-97-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(3,4-dichlorophenyl)hexanamide
• 英文别名: 3,4-Dichlorcaproanilid；3',4'-Dichlor-hexananilid
• CAS: 2150-97-2
• 化学式: C₁₂H₁₅Cl₂NO
• 分子量: 260.163
• InChiKey: UHNACMYDEPKBKS-UHFFFAOYSA-N

物化性质

• 熔点：
  72-74 °C
• 沸点：
  402.3±35.0 °C(Predicted)
• 密度：
  1.224±0.06 g/cm3(Predicted)
• 保留指数：
  2127

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  3,4-二氯苯胺 生成 N-(3,4-dichlorophenyl)hexanamide
  参考文献：
  名称：

  BISTLINE, R. G.;MAURER, E. W.;SMITH, F. D.;LINFIELD, W. M.

  摘要：

  DOI：

文献信息

• Synthesis of aryloxyacetylthiourea derivatives for the development of radicle elongation inhibitor of parasitic weeds
  作者：Motohiro Sonoda、Yusuke Mimura、Shizuki Noda、Atsushi Okazawa

  DOI：10.1016/j.tet.2023.133333

  日期：2023.4

  yl)thiourea (PI-28), has attracted attention as a lead compound for the development of radicle elongation inhibitors in Orobanche minor seeds germination. In this study, we synthesized PI-28 and its derivatives in two steps using commercially available phenols, 2-chloroacetamide, and N-aryl isothiocyanates. In this method, 2-aryloxyacetanilides, which are also attractive as bioactive compounds, were

  芳氧基乙酰基硫脲，1-(3,4-二氯苯基)-3-(2-苯氧基乙酰基)硫脲 (PI-28) 作为先导化合物引起了人们的关注，该化合物用于开发列班列小种子萌发中的胚根伸长抑制剂。在这项研究中，我们使用市售的酚类、2-氯乙酰胺和N分两步合成了 PI-28 及其衍生物-芳基异硫氰酸酯。在该方法中，获得作为生物活性化合物也很有吸引力的 2-芳氧基乙酰苯胺作为副产物。根据对照实验的结果，副产物的形成是由于在反应过程中另一种芳基异硫氰酸酯的作用导致形成的芳酰氧基乙酰硫脲中异硫氰酸酯部分的损失。此外，我们还开发了一种 PI-28 衍生物的一锅法合成方法，总收率相当。
• Production of aryl acylamidases
  申请人：The Public Health Laboratory Service Board

  公开号：EP0053890A1

  公开（公告）日：1982-06-16

  A process for the production of an aryl acylamidase enzyme involves culturing bacteria of one of the strains Pseudomonas fluorescens ATCC 39005 (or suitable mutants or variants thereof) or Pseudomonas putida ATCC 39004 (or suitable mutants or variants thereof) in a culture medium in which the bacterial strains produce aryl acylamidase and collecting the enzyme containing material, generally the cell material. Preferably the resulting cells are then disrupted, especially by enzymatic treatment, and the aryl acylamidase is separated from the other unwanted substances, generally the other cell constituents. Preferably the culture medium contains N - acylaniline, especially N - acetyl aniline. The N - acylaniline may form part of a complex or defined salts medium.

  生产芳基酰氨基酶的工艺包括在培养基中培养荧光假单胞菌 ATCC 39005 株（或其适当的突变体或变种）或腐生假单胞菌 ATCC 39004 株（或其适当的突变体或变种）中的一种菌株的细菌，在培养基中细菌菌株产生芳基酰氨基酶，并收集含酶物质，通常是细胞物质。最好将得到的细胞破碎，特别是通过酶处理，然后将芳基酰氨基酶与其他不需要的物质（一般是其他细胞成分）分离。 培养基中最好含有 N-酰基苯胺，尤其是 N-乙酰苯胺。N -酰基苯胺可构成复合培养基或定义盐培养基的一部分。
• N-(3-chloro-4-isopropylphenyl)carboxamides, process for producing them, and selective herbicides containing them
  申请人：MITSUI TOATSU CHEMICALS, Inc.

  公开号：EP0205271A1

  公开（公告）日：1986-12-17

  An N-(3-chloro-4-isopropylphenyl)carboxamide derivative represented by the general formula wherein R represents a 1-methylbutyl, 1-methylcyclopropyl or cyclopropyl group. This derivative is useful as a selective herbicide, and can be pro- duced by reacting 3-chloro-4-isopropylaniline with a carboxylic acid halide derivative of the general formula wherein R is as defined above and X represents halogen, or with a carboxylic acid anhydride of the general formula wherein R is as defined above.

  由通式代表的 N-(3-氯-4-异丙基苯基)甲酰胺衍生物 其中 R 代表 1-甲基丁基、1-甲基环丙基或环丙基。这种衍生物可用作选择性除草剂，可通过将 3-氯-4-异丙基苯胺与通式如下的羧酸卤化物衍生物反应制得 其中 R 如上文所定义，X 代表卤素，或与通式的羧酸酸酐反应 其中 R 如上定义。
• Pyridyloxypyrimidine derivatives, preparation process thereof, and herbicidal compositions containing the same as active ingredients
  申请人：MITSUI TOATSU CHEMICALS, Inc.

  公开号：EP0435186A2

  公开（公告）日：1991-07-03

  Pyridyloxypyrimidine derivatives represented by the following formula [I]: wherein R means a formyl group or an acetal group represented by R¹ and R² being the same or different and individually denoting an alkyl group having 1-4 carbon atoms or R¹ and R² being coupled together and denoting an alkylene group, R³, having 2-3 carbon atoms; preparation processes of the derivatives; and herbicidal compositions containing one or more of the derivatives as an active ingredient.

  下式[I]代表的吡啶氧基嘧啶衍生物： 其中 R 指甲酰基团或乙缩醛基团，其代表为 R¹和R²相同或不同，单独表示具有1-4个碳原子的烷基，或R¹和R²连接在一起，表示具有2-3个碳原子的亚烷基R³；衍生物的制备工艺；以及含有一种或多种衍生物作为活性成分的除草组合物。
• New strains of Drechslera spp., and weed control agents and weed control compositions containing the same
  申请人：MITSUI TOATSU CHEMICALS, Inc.

  公开号：EP0464416A2

  公开（公告）日：1992-01-08

  Described are new strains of Drechslera spp., which possess herbicidal effects against all varieties of barnyard grass, i.e., Echinochloa spp. as weed but do not give any influence to crops under cultivation such as rice. Weed control agents according to the present invention, which contain one or more of the novel strains, have high safety and selectivity, thereby providing practical control effects against barnyard grass. Weed control compositions according to the present invention, which contain one or more of the new strains in combination with one or more chemical herbicides, have sufficient herbicidal effects even at dosages which are too low to permit control of weeds when they are applied singly, thereby making it possible to reduce the dosage of herbicides. The weed control compositions can therefore contribute to the prevention of environmental pollution and the occurrence of weeds with acquired pesticide resistance.

  本发明描述了 Drechslera 属的新菌株，它们对所有品种的稗草（即作为杂草的 Echinochloa 属）都具有除草效果，但不会对水稻等栽培作物造成任何影响。根据本发明的杂草控制剂含有一种或多种新型菌株，具有很高的安全性和选择性，因此对稗草具有实际的控制效果。根据本发明的除草组合物含有一种或多种新菌株，并与一种或多种化学除草剂结合使用，具有足够的除草效果，即使在单独使用时，由于剂量太低而无法控制杂草，从而可以减少除草剂的用量。因此，这种除草组合物有助于防止环境污染和获得性抗药性杂草的出现。